DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and Ces5a

DIOPT Version :9

Sequence 1:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001368779.1	Gene:	Ces5a / 67935	MGIID:	1915185	Length:	579	Species:	Mus musculus

Alignment Length:	627	Identity:	172/627 - (27%)
Similarity:	284/627 - (45%)	Gaps:	118/627 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 TSSGPVRGRSVTVQGR--EVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQERY 109
            |..|.|:|:..||.||  .|:|:.|||:|.||:..|||.||.|..||..:.:||.....|.|...
Mouse    39 TKLGWVQGKQATVLGRLEPVNVFLGIPFAAPPLGPLRFSKPQPPIPWDNLREATAYPNLCFQNLE 103

  Fly   110 EYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQN 174
            ..|...:..::..|...:||||||:|::||..|                               |
Mouse   104 WLFIYQNLLKVSYPILGMSEDCLYLNIYAPCHA-------------------------------N 137

  Fly   175 TTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEE 239
            ..:.||:::||.||||.||||:  |::...:|...:|:|.:.|||:|.|||.       :...:.
Mouse   138 NGSSLPVMVWIPGGGFETGSAS--IFDGSALAVYEDVLVVTIQYRLGIFGFF-------TTQNQH 193

  Fly   240 APGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGT 304
            ||||...|||..|:.|:::|...|||||:.:|:||.|||:.|:::.::||::..|..|.:||||.
Mouse   194 APGNWAFWDQLAALLWVRENIKYFGGNPDSVTIFGNSAGAISISSLILSPLSADLFHRAIMQSGV 258

  Fly   305 MNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMR---SVDAKTISVQQWNSYSGIL 366
            ...|....:........:.:.|.|:||.|..|.    ::.|:|   |::..::| |:..|::.:
Mouse   259 AIIPSLKSSDNDLKHDLQVVANVCDCNVSDSKA----LLKCLREKSSLELMSLS-QKAKSFTRV- 317

  Fly   367 SFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFL-LYDFID-YFDKDDATAL--- 426
                   :||:|...:|:.|:....||....::|....|..|.| :.|..: ....:::|||
Mouse   318 -------VDGSFFSEEPLELLSQKTLKIVPSIIGVNNQECGYILPVRDTPEILLGSNESTALTLI 375

  Fly   427 -------PRDKYLEIMNNIFGKATQAE-REAIIFQYTSWEGNPGYQNQQQIGRAVGDHFFTCPTN 483
                   .:..|:.......||.:..: |:.::..:                   ||.||..|..
Mouse   376 HTLLHIPTQHLYIVTKEYFHGKHSPTDIRDTLLDLF-------------------GDVFFVVPGL 421

  Fly   484 EYAQALAERGASVHYYYFTHRTS--TSLWGEWMGVLHGDEIEYFFGQPL--NNSLQYRPV---ER 541
            ..|:...:.|..|::|.|.||..  .:....::...|.|||.:.||.|.  .:.:.:...   |:
Mouse   422 VTARYHRDSGGPVYFYEFQHRPHCFQNSRPAFVKADHTDEIRFVFGGPFLKGDVVMFEEATEEEK 486

  Fly   542 ELGKRMLSAVIEFAKTGNP-AQDGEEWPNFSKEDPVYYI---FSTDDKIEKLARGPLAARCSFWN 602
            .|.::|:.....||::|:| ..|...||.:.:.:....:   .||..:::.       .|..||.
Mouse   487 LLSRKMMKYWANFARSGDPNGADLPPWPVYDENEQYLELDVNISTGRRLKD-------QRVEFWT 544

  Fly   603 DYLPKVRSWAGTCDGDSGSASISP--RLQLLGIAALIYICAA 642
            |.||.:.|        :..|.:||  .|.||.:.:.:.:.||
Mouse   545 DTLPLILS--------ASKALLSPTFSLILLSLLSPVLLSAA 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	158/582 (27%)
Ces5a	NP_001368779.1	COesterase	33..543	CDD:395084	158/582 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810