DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and LOC679149

DIOPT Version :9

Sequence 1:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001094469.1	Gene:	LOC679149 / 679149	RGDID:	1591847	Length:	561	Species:	Rattus norvegicus

Alignment Length:	623	Identity:	177/623 - (28%)
Similarity:	267/623 - (42%)	Gaps:	115/623 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VLVLSLHLSGVCGVIDRLVVQTSSGPVRGRSVTVQGRE--VHVYTGIPYAKPPVEDLRFRKPVPA 88
            :|:|.:|:.|........:..|..|.|||:...|:..:  ||.:.|||:|||||..|||..|...
  Rat    17 LLLLLIHVQGQHSPESSPIRNTHIGQVRGKLDHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAP 81

  Fly    89 EPWHGVLDATRLSATCVQE----RYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRG 149
            |||.||.|.|...|.|:|.    ..|   |....::..|..::||||||:|::|||.|
  Rat    82 EPWSGVRDGTSQPAMCLQNLDVINAE---GLKEMKLKLPPVSMSEDCLYLNIYAPAHA------- 136

  Fly   150 ANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVA 214
                              |.|      :.||:::||:|||.|||.|::  |:..::....:::|.
  Rat   137 ------------------HEG------SNLPVMVWIHGGGLMTGMASM--YDGSLLTVNEDLVVV 175

  Fly   215 SFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGS 279
            :.|||:|..||.       |...|.|.||.|..||..|:||::.|...|||||:.:|:||||||.
  Rat   176 TIQYRLGVLGFF-------STGDEHARGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGG 233

  Fly   280 SSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMS 344
            :.|:..::||:::||....:|:||....|:              ||.|   .:.|..|..|.|..
  Rat   234 TCVSTHVVSPMSQGLFHGAIMESGVALLPY--------------LIAD---TSEMFSTMVAKVSG 281

  Fly   345 CMRSVDAKTISVQQWNSYSGILSFPSA-----PTIDGAFLPADPMTLMKTADLKDYDILMGNVRD 404
            |........:...:..|.:.||:....     ..:||.|||..|..|:.:.|.:....::|...|
  Rat   282 CEAMDSEALVHCLRAKSEAEILAINKVVQMVPAVVDGEFLPRHPKELLASEDFRPVPSIIGVNND 346

  Fly   405 E---------GTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAE-------REAIIFQ 453
            |         ||..::.:            |.|:....|:     |.|.|:       .:.::.:
  Rat   347 EYGWTIPLVMGTTQMIKE------------LSRENLQAIL-----KKTTAQLMLPLECSDLLMEE 394

  Fly   454 YTSWEGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTS--TSLWGEWMGV 516
            |.....:| ...|.|....:.|..|..|..:.|...... |.|::|.|.|:.:  ..:....:..
  Rat   395 YMGDIEDP-KTLQAQFTELMEDFMFVIPALQVAHFQCSH-APVYFYEFQHQITFLKDIRPPHVKA 457

  Fly   517 LHGDEIEYFFGQPL-NNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDG-EEWPNFSKEDPVYYI 579
            .|||||.:.||... :....:...|:.|.:||:.....||:.|||..:| ..|| ....|..|..
  Rat   458 DHGDEIPFVFGYFFWDMKTDFTEEEKLLSRRMMKYWANFARHGNPNSEGLSYWP-VMDHDQQYLQ 521

  Fly   580 FSTDDKIEKLARGPLAARCSFWNDYLP-KVRSWAGTCD 616
            ..|...:   .|...|.|..||...|| |::...|..|
  Rat   522 LDTQPAV---GRALKARRLQFWTKTLPQKIQELKGAQD 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	166/590 (28%)
LOC679149	NP_001094469.1	COesterase	31..540	CDD:278561	166/591 (28%)
LOC679149	NP_001094469.1	Aes	<130..>233	CDD:223730	48/142 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810