DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and NLGN3

DIOPT Version :9

Sequence 1:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_851820.1	Gene:	NLGN3 / 54413	HGNCID:	14289	Length:	848	Species:	Homo sapiens

Alignment Length:	770	Identity:	203/770 - (26%)
Similarity:	309/770 - (40%)	Gaps:	182/770 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RVLPMSLPLPLTIPLPLV----------LVLSLHLSGVCGVIDRLVVQTSSGPVRGRSVTVQGR- 62
            |:.|.||.|.   |.|.|          |.|:|..|...   ....|.|..|.:||..|.:...
Human     4 RLGPPSLSLS---PKPTVGRSLCLTLWFLSLALRASTQA---PAPTVNTHFGKLRGARVPLPSEI 62

  Fly    63 --EVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQERYEYFPGFSGEEIWNP-- 123
              .|..|.|:|||.||:.:.||..|.|...|.|:.:||.....|.|..:...|     |:..|
Human    63 LGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVP-----EVMLPVW 122

  Fly   124 ---NTNV--------SEDCLYINVWAPA----------------KARLRHGRGA-NGGEHPNGKQ 160
               |.::        :|||||:||:.|.                |...:.|.|| ..||......
Human   123 FTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLADND 187

  Fly   161 ADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGF 225
            .|.|..|.:...:      |::::|:||.:|.|  |.::.:..|:|:.|||||.:..||||..||
Human   188 GDEDEDIRDSGAK------PVMVYIHGGSYMEG--TGNMIDGSILASYGNVIVITLNYRVGVLGF 244

  Fly   226 LHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPV 290
            |       |...:.|.||.||.||..|:||:.:|...|||:|..:|:||...|:|.|:...:|..
Human   245 L-------STGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHH 302

  Fly   291 TRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRSVDAKTIS 355
            :.||.:|.::|||:..:.|:  .:.:.|:....|.:...||  :|.|  ..::.|:|...||.:.
Human   303 SEGLFQRAIIQSGSALSSWA--VNYQPVKYTSLLADKVGCN--VLDT--VDMVDCLRQKSAKELV 361

  Fly   356 VQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDK 420
            .|........::|  .|.|||..:|.||..||:..:..:|||::|..:.||..|:    ....|.
Human   362 EQDIQPARYHVAF--GPVIDGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFV----EGVVDP 420

  Fly   421 DDATALPRDKY--LEIMNNIFG--KATQAEREAIIFQYTSW--EGNPGYQNQQQIGRAVGDHFFT 479
            :|..:.....|  ...::|::|  :.....||.|.|.||.|  ..||..:.:..:. ...||.:.
Human   421 EDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKTLVA-LFTDHQWV 484

  Fly   480 CPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELG 544
            .|:...|...|..|:..::|.|.|...:.:...|....||||:.|.||.|:.......|......
Human   485 EPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKN 549

  Fly   545 KRMLSAVI-----EFAKTGNP--------------AQDGEE--WPNFSKEDPVYYIFSTDDKIEK 588
            ..|||||:     .|||||:|              |...||  |..::..|.:|.......::..
Human   550 DVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIGLKPRVRD 614

  Fly   589 LARGPLAARCSFWNDYLPKV---------------------------------RSWA-------- 612
            ..|   |.:.:||...:|.:                                 ::|:
Human   615 HYR---ATKVAFWKHLVPHLYNLHDMFHYTSTTTKVPPPDTTHSSHITRRPNGKTWSTKRPAISP 676

  Fly   613 --------GTCDGDSGSASI---SPR------------------LQLLGIAALIY 638
                    |:.:||..:..:   :||                  |.:|..|||.|
Human   677 AYSNENAQGSWNGDQDAGPLLVENPRDYSTELSVTIAVGASLLFLNVLAFAALYY 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	176/619 (28%)
NLGN3	NP_851820.1	COesterase	36..624	CDD:278561	177/626 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..195		7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..694		4/48 (8%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910