DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and Ces2h

DIOPT Version :9

Sequence 1:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001258974.1	Gene:	Ces2h / 436059	MGIID:	3648740	Length:	558	Species:	Mus musculus

Alignment Length:	604	Identity:	177/604 - (29%)
Similarity:	270/604 - (44%)	Gaps:	102/604 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SGVCGVIDRLVVQ----------TSSGPVRGRSVTVQGRE--VHVYTGIPYAKPPVEDLRFRKPV 86
            :..||::..|.||          |.:|.:.|..:.::..:  ||.:.|||:|||||..|||..|.
Mouse    12 TATCGLLLLLRVQGQDSTSPIRTTHTGQILGSLIHMKDLDVGVHSFLGIPFAKPPVGPLRFAPPE 76

  Fly    87 PAEPWHGVLDATRLSATCVQE-RYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGA 150
            |.|||.||.|.|...|.|:|: .......|...::..|...:||||||:|::||
Mouse    77 PPEPWGGVRDGTSHPAMCLQDITAMNMQAFKLLKLTLPPFPMSEDCLYLNIYAP----------- 130

  Fly   151 NGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVAS 215
                         || .|.|      :.||:::||:||..:.|.|::  |:..::||:.||:|.:
Mouse   131 -------------DH-AHEG------SNLPVMVWIHGGSLVIGMASM--YDGSMLAAMENVVVVT 173

  Fly   216 FQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSS 280
            .|||:|..||.       |...|.|.||.|..||..|:|||:.|...|||||:.:|:||.|||.:
Mouse   174 IQYRLGVLGFF-------STGDERARGNWGYLDQVAALRWLQQNIAYFGGNPDRVTIFGTSAGGT 231

  Fly   281 SVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSC 345
            ||::.::||:::||.:..:|:||.  |..|.:.|..:..:.:.:.|...|.    :.:...:::|
Mouse   232 SVSSLVVSPMSQGLFRGAIMESGV--ALISSLISVSSDVVYQTVANLSGCE----QVDSEALVNC 290

  Fly   346 MRSVDAKTISV--QQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNVRDEGTY 408
            :|....:.|..  :.:....||        :||.|||..|..||.:||......::|...||
Mouse   291 LRGKSEEEIMAINKAFKIIPGI--------VDGIFLPRHPQELMASADFHPVPSIIGVNNDE--- 344

  Fly   409 FLLYDFI---DYFDKDDATALPRDKYLEIMNNIFGKATQ-----AEREAIIFQYTSWEGNPGYQN 465
               |.:|   .....|....:.|.....|:..   :|||     ...:.::.:|.....:|.:.
Mouse   345 ---YGWIIPSSMSMIDSKKGMDRQMVQAILQR---RATQMMWPPEVSDLLMEEYMGDNEDPQFL- 402

  Fly   466 QQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVL--HGDEIEY---- 524
            |.|....:.|..|..|..:.|| .....|.|.:|.|.||.|.....:...|.  |||||.:
Mouse   403 QVQFKEMMKDFTFVIPALQVAQ-FQRSHAPVFFYEFQHRPSFFKDSKPSHVKADHGDEILFIFRS 466

  Fly   525 FFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDG-EEWPNFSKEDPVYYIFSTDDKIEK 588
            |:|   ...:.:...|..|.:||:.....||:..||..:| ..||.|. :|..|....|...:
Mouse   467 FWG---GTQVDFTEEEELLSRRMMKYWANFARQRNPNSEGLPYWPMFD-QDEQYLQLDTQPAV-- 525

  Fly   589 LARGPLAARCSFWNDYLPK 607
             .|.....|..||...||:
Mouse   526 -GRALKTRRLQFWTKTLPE 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	171/589 (29%)
Ces2h	NP_001258974.1	COesterase	30..537	CDD:278561	168/578 (29%)
Ces2h	NP_001258974.1	Aes	<127..>230	CDD:223730	49/142 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810