Protein Alignment Ace and ACHE

DIOPT Version :9

• Sequence 1: NP_001163600.1
• Gene: Ace / 41625
• FlyBaseID: FBgn0000024
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001354847.1
• Gene: ACHE / 43
• HGNCID: 108
• Length: 681
• Species: Homo sapiens
• Alignment Length: 625
• Identity: 222/625 - (35%)
• Similarity: 327/625 - (52%)
• Gaps: 54/625 - (8%)

  Fly     4 SCRQSRVLPMSLPLPLTIPLPLVLVLSLHLSGVCGVIDR----LVVQTSSGPVRGRSVTVQGREV 64
            :|..:...|..|....::..||:|:|...|.|..|...|    |:|....|.:||..:...|..|
Human    63 ACPAAMRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV 127

  Fly    65 HVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQERYEYFPGFSGEEIWNPNTNVSE 129
            ..:.|||:|:||:...||..|.|.:||.||:|||...:.|.|.....:|||.|.|:||||..:||
Human   128 SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSE 192

  Fly   130 DCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGS 194
            ||||:|||.|               :|                 ..|:..|:|:|||||||.:|:
Human   193 DCLYLNVWTP---------------YP-----------------RPTSPTPVLVWIYGGGFYSGA 225

  Fly   195 ATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDN 259
            ::||:|:...:......::.|..|||||||||.|    |.  :.||||||||.||.||::|:::|
Human   226 SSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLAL----PG--SREAPGNVGLLDQRLALQWVQEN 284

  Fly   260 AHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKAL 324
            ..||||:|..:||||||||::||...|:||.:|||..|.::|||..|.||:.:...:|......|
Human   285 VAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQL 349

  Fly   325 INDCNCNASMLKTNPAHVMSCMRSVDAKTISVQQWN--SYSGILSFPSAPTIDGAFLPADPMTLM 387
            .:...|.......|...:::|:|:..|:.:...:|:  ....:..|...|.:||.||...|..|:
Human   350 AHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALI 414

  Fly   388 KTADLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIF 452
            ...|.....:|:|.|:|||:|||:|. ...|.||:.:.:.|.::|..:.....:.:....||::.
Human   415 NAGDFHGLQVLVGVVKDEGSYFLVYG-APGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVL 478

  Fly   453 QYTSW--EGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMG 515
            .||.|  ..:|. :.::.:...||||...||..:.|..||.:||.|:.|.|.||.||..|..|||
Human   479 HYTDWLHPEDPA-RLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMG 542

  Fly   516 VLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDGE----EWPNFSKEDPV 576
            |.||.|||:.||.||:.|..|...|:...:|::.....||:||:|.:..:    :||.::.....
Human   543 VPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ 607

  Fly   577 YYIFSTDDKIEKLARGPLAARCSFWNDYLPKVRSWAGTCD 616
            |  .|.|.:..::.||..|..|:|||.:|||:.|...|.|
Human   608 Y--VSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLD 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	203/571 (36%)
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	202/567 (36%)
		AChE_tetra	645..678	CDD:400834	1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	378	1.000	Domainoid score	I862
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	390	1.000	Inparanoid score	I2008
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45275
OrthoDB	1	1.010	-	-		D339133at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm40789
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2380
SonicParanoid	1	1.000	-	-		X1321
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.910