DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and Est-P

DIOPT Version :9

Sequence 1:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	649	Identity:	153/649 - (23%)
Similarity:	241/649 - (37%)	Gaps:	191/649 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LVLVLSLHLSGVCGVIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVP-A 88
            |:.:..|.::.:....|.|:|:.::|.:||:...:    .:.|..||.|:.|...|||..|.| :
  Fly     7 LLCLTLLWIAALESEADPLIVEITNGKIRGKDNGL----YYSYESIPNAEHPTGALRFEAPQPYS 67

  Fly    89 EPWHGVLDATRLSATCVQERYEYFPGFSGEEIWNPNTNVS------EDCLYINVWAPAKARLRHG 147
            ..|..|.:||:....|:|              ||...|.:      ||||.::::.|.|
  Fly    68 HHWTDVFNATQSPVECMQ--------------WNQFINENNKLMGDEDCLTVSIYKPKK------ 112

  Fly   148 RGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVI 212
                    ||                  .:..|:::.::||.||.||.:  ||..|.:...|.::
  Fly   113 --------PN------------------RSSFPVVVLLHGGAFMFGSGS--IYGHDSIMREGTLL 149

  Fly   213 VASFQYRVGAFGFL-----HLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTL 272
            |....:.:|..||.     ||            |||.||.||.||::|:|.|...|||.|:.:.|
  Fly   150 VVKISFGLGPLGFASTGDRHL------------PGNYGLKDQRLALQWIKKNIAHFGGMPDNIVL 202

  Fly   273 FGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPW--SHMTSEKAVEIGK----------ALI 325
            .|.|||.:|.:.||:....:.|.|..:..||....||  ......:|.|:|:          |.:
  Fly   203 IGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAFELGRIVGCGHTNVSAEL 267

  Fly   326 NDCNCNASMLKTNPA-HVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKT 389
            .||      ||:.|| .::|.:||.  ...|...::::..::....||   .|||..||..::|:
  Fly   268 KDC------LKSKPASDIVSAVRSF--LVFSYVPFSAFGPVVEPSDAP---DAFLTEDPRAVIKS 321

  Fly   390 ADLKDYDILMGNVRDEGTY-----------------FLL----YDFIDYF-----------DKDD 422
            .........:....::|.|                 .||    :|:..|.           |.||
  Fly   322 GKFAQVPWAVTYTTEDGGYNAAQLLERNKLTGESWIDLLNDRWFDWAPYLLFYRDAKKTIKDMDD 386

  Fly   423 ATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGNPGYQN---QQQIGRAVGDH-------- 476
            .:...|.:||            |:|...:..|  |.....:.:   :..:..|:..|
  Fly   387 LSFDLRQQYL------------ADRRFSVESY--WNVQRMFTDVLFKNSVPSAIDLHRKYGKSPV 437

  Fly   477 ---FFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQY-- 536
               .:..||:.....|......||:                |.:|||:....|     |:..|
  Fly   438 YSFVYDNPTDSGVGQLLSNRTDVHF----------------GTVHGDDFFLIF-----NTAAYRT 481

  Fly   537 --RPVERELGKRMLSAVIEFAKTGNPAQDGEEWPNF-----SKEDPVYYIFSTDDKIEKLARGP 593
              ||.|..:.|:.:..:.:||..........|. ||     |||..|..|.....|.|:.||.|
  Fly   482 GIRPDEEVISKKFIGMLEDFALNDKGTLTFGEC-NFQNNVNSKEYQVLRISRNACKNEEYARFP 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	151/633 (24%)
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	144/621 (23%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	50/178 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440347
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840