DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and Est-6

DIOPT Version :9

Sequence 1:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	579	Identity:	147/579 - (25%)
Similarity:	249/579 - (43%)	Gaps:	116/579 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 IPLPLVLVLS-LHL-SGVCGVIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFR 83
            :.|.|::||| |.| |......|.|:||...|.:|||    .....:.|..||||:||..||||.
  Fly     4 VGLGLIIVLSCLWLGSNASDTDDPLLVQLPQGKLRGR----DNGSYYSYESIPYAEPPTGDLRFE 64

  Fly    84 KPVP-AEPWHGVLDATRLSATCVQERYEYF-PGFS---GEEIWNPNTNVSEDCLYINVWAPAKAR 143
            .|.| .:.|..:.|||:....|:|  ::.| ||.:   ||          ||||.::|:.|
  Fly    65 APEPYKQKWSDIFDATKTPVACLQ--WDQFTPGANKLVGE----------EDCLTVSVYKP---- 113

  Fly   144 LRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAV 208
                        .|.|:                |..|::..|:||.||.|:|..:.:. ::|..
  Fly   114 ------------KNSKR----------------NSFPVVAHIHGGAFMFGAAWQNGHE-NVMRE- 148

  Fly   209 GNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLF 273
            |..|:....||:|..||:       |....:.|||.||.||.||::|:|.|..:|||.|:.:.|.
  Fly   149 GKFILVKISYRLGPLGFV-------STGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLV 206

  Fly   274 GESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPW--SHMTSEKAVEIGKALINDCNCNASMLK 336
            |.|||.:||:.|::......|.:.....||....||  ......:|.|:|:    :..|.::...
  Fly   207 GHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFELGR----NVGCESAEDS 267

  Fly   337 TNPAHVMSCMRSVDAKTI--SVQQWNSYSGILSFPSAPTID-----GAFLPADPMTLMKTADLKD 394
            |:   :..|::|..|..:  :|:::..:|.:...|.:|.::     .|.:..||..::|:.....
  Fly   268 TS---LKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPSDAPDAIITQDPRDVIKSGKFGQ 329

  Fly   395 YDILMGNVRDEGTY---FLLYDFIDYFDKDDATALPRDKYLEIMNN-IFGKATQAEREAIIFQYT 455
            ....:..|.::|.|   .||.:.......||.    .:::||:... :|.:.|:.:::  :..|:
  Fly   330 VPWAVSYVTEDGGYNAALLLKERKSGIVIDDL----NERWLELAPYLLFYRDTKTKKD--MDDYS 388

  Fly   456 -----SWEGNPGY--QNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYY------------- 500
                 .:.||..:  ::..::.|...|..|...|.|......:.|.|..|.|
  Fly   389 RKIKQEYIGNQRFDIESYSELQRLFTDILFKNSTQESLDLHRKYGKSPAYAYVYDNPAEKGIAQV 453

  Fly   501 FTHRTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGN 559
            ..:||...     .|.:|||:....| :.....::.||.|:.:.:..::.:.:||.:.|
  Fly   454 LANRTDYD-----FGTVHGDDYFLIF-ENFVRDVEMRPDEQIISRNFINMLADFASSDN 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	139/557 (25%)
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	137/554 (25%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	50/173 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440346
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840