Protein Alignment Ace and Ces3a

DIOPT Version :9

• Sequence 1: NP_001163600.1
• Gene: Ace / 41625
• FlyBaseID: FBgn0000024
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_941074.1
• Gene: Ces3a / 382053
• MGIID: 102773
• Length: 571
• Species: Mus musculus
• Alignment Length: 610
• Identity: 167/610 - (27%)
• Similarity: 267/610 - (43%)
• Gaps: 133/610 - (21%)

  Fly    45 VQTSSGPVRGRSVTVQ--GREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQ- 106
            |.|..|.||||.|.|:  .|.|:|:.|||:|:.|:..|||..|:|.:||.||.||:.....|:|
Mouse    39 VDTPLGRVRGRQVGVKDTDRMVNVFLGIPFAQAPLGPLRFSAPLPPQPWEGVRDASINPPMCLQD 103

  Fly   107 ------------ERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGK 159
                        |:.:.||             :|||||.:|:::|.:
Mouse   104 VERMSNSRFTLNEKMKIFP-------------ISEDCLTLNIYSPTE------------------ 137

  Fly   160 QADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFG 224
                   |..|:.:      |:::||:||..:.||:|  .::...:||.|:|:|.:.|||:|.||
Mouse   138 -------ITAGDKR------PVMVWIHGGSLLVGSST--SHDGSALAAYGDVVVVTVQYRLGIFG 187

  Fly   225 FLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSP 289
            ||       |...:..|||.|..|...|:||::.|...|||:|..:|:||.|||...|::.|:||
Mouse   188 FL-------STGDKHMPGNRGFLDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLLSP 245

  Fly   290 VTRGLVKRGMMQSGT--------MNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCM 346
            ::.||..|.:.|||.        :|| ||.         .:...|...|.::    :||.::.|:
Mouse   246 MSAGLFHRAISQSGVVISKILEDLNA-WSE---------AQNFANSVACGSA----SPAELVQCL 296

  Fly   347 RSVDAK-TISVQQWN-SYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYF 409
            ...:.| .|:.:..| ||          |::.:|.|..|..|:..........|:|....|..:.
Mouse   297 LQKEGKDLITKKNVNISY----------TVNDSFFPQRPQKLLANKQFPTVPYLLGVTNHEFGWL 351

  Fly   410 LL-----YDFIDYFDKDD--ATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGNPGYQNQQ 467
            ||     .|.:::..::|  ..:.|...::::...|.        ..:|.:|.. .|:.....:.
Mouse   352 LLKFWNILDKMEHLSQEDLLENSRPLLAHMQLPPEIM--------PTVIDEYLD-NGSDESATRY 407

  Fly   468 QIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTST--SLWGEWMGVLHGDEIEYFFGQPL 530
            .:...:||.....||..:::.|.:.|..|..|.|.|..|:  .....|:...|..|..:.||.|.
Mouse   408 ALQELLGDITLVIPTLIFSKYLQDAGCPVFLYEFQHTPSSFAKFKPAWVKADHSSENAFVFGGPF 472

  Fly   531 ---NNSLQYRP----VERELGKRMLSAVIEFAKTGNPAQDG-EEWPNFSKEDPVYYIFSTDDKIE 587
               .:||...|    .|::|...|::...:||:||||...| ..||..::.:....|........
Mouse   473 LTDESSLLAFPEATEEEKQLSLTMMAQWSQFARTGNPNGKGLPPWPQLNQLEQYLEIGLEPRTGV 537

  Fly   588 KLARGPLAARCSFWNDYLP-KVRSW 611
            ||.:|    |..||.:.|| |::.|
Mouse   538 KLKKG----RLQFWTETLPRKIQEW 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	161/597 (27%)
Ces3a	NP_941074.1	COesterase	36..547	CDD:278561	161/597 (27%)
		Aes	75..>245	CDD:223730	68/222 (31%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910