DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and Ces1b

DIOPT Version :9

Sequence 1:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001074841.1	Gene:	Ces1b / 382044	MGIID:	3779470	Length:	567	Species:	Mus musculus

Alignment Length:	609	Identity:	168/609 - (27%)
Similarity:	271/609 - (44%)	Gaps:	125/609 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 VVQTSSGPVRGRSVTVQGRE--VHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQ 106
            ||.|:.|.:.|:..:::|.|  |.|:.|:|:||||:..|||..|.|||||..|.:||.....|.|
Mouse    25 VVDTTQGKILGKYTSLEGFEHPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKNATSYPPMCSQ 89

  Fly   107 E-------------RYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPA---KARLRHGRGANGGEH 155
            :             :.|..|..           .||||||:|:::||   |:.|
Mouse    90 DAVAVQLLSDMLSTKKESIPPL-----------FSEDCLYLNIYSPADLTKSSL----------- 132

  Fly   156 PNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRV 220
                                   ||:::||:|||.|||.|:|  ||...::|..||:|.:.|||:
Mouse   133 -----------------------LPVMVWIHGGGLMTGGASL--YNGLALSAHENVVVVTIQYRL 172

  Fly   221 GAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQ 285
            |.:|..       |...|.:.||....||..|:||::||...|||||:.:|:||.|||..||:..
Mouse   173 GIWGLF-------STGDEHSRGNWAHLDQLAALRWVQDNIANFGGNPDSVTVFGSSAGGVSVSVL 230

  Fly   286 LMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRSVD 350
            ::||:.:.|..|.:.:|..:...........|.::.:.:.....||    .|:...::.|:|.
Mouse   231 VLSPLAKNLFHRAISESSVVLENIVITLDLVACDLSQMIATVSGCN----DTSSTAMVQCLRQ-- 289

  Fly   351 AKT------ISVQ-QWNSYSGILSFPSAPT-----IDGAFLPADPMTLMKTADLKDYDILMGNVR 403
             ||      |:|: :.....|..|.....|     |||..||..|..::..........::|..:
Mouse   290 -KTENELLEITVKLEVTKVGGAASAKKDNTSMSTVIDGVVLPKAPEEILAEKSFSTVPYIVGFNK 353

  Fly   404 DEGTYF---LLYDFID--YFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGNPGY 463
            .|..:.   :|.|.:.  ..:::.|:.|.|..:.::  ||    :::...|:|.:|.....:|.
Mouse   354 QEFGWIIPTMLGDLLSEGKMNEETASLLLRRFHSDL--NI----SESLIPAVIEKYLRGTDDPA- 411

  Fly   464 QNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTS-------TSLWGEWMGVLHGDE 521
            :.:..:.....|.||..|....:::|.:.|.|.:.|.|.:|.|       .::.|:     ||||
Mouse   412 KKRDLLLDMFSDVFFGIPAVLLSRSLRDAGVSTYMYEFRYRPSFVSDKRPQTVEGD-----HGDE 471

  Fly   522 IEYFFGQPLNNSLQYRPVERE--LGKRMLSAVIEFAKTGNPAQDG-EEWPNFSKEDPVYYIFSTD 583
            |...||.||   |:....|.|  |.|.::.....||:.|||..:| ..||.:.:::....|.:|.
Mouse   472 IFSVFGIPL---LKEGTSEEETNLSKMVMKFWANFARNGNPNGEGLPHWPEYDEKEGYLQIGATT 533

  Fly   584 DKIEKLARGPLAARCSFWNDYLPK 607
            .:.::|.    |...:||.:.|.|
Mouse   534 QQAQRLK----AEEVAFWTELLAK 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	164/601 (27%)
Ces1b	NP_001074841.1	COesterase	19..547	CDD:278561	164/601 (27%)
Ces1b	NP_001074841.1	Aes	<121..>239	CDD:223730	53/160 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810