DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and Ces5a

DIOPT Version :9

Sequence 1:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001012056.2	Gene:	Ces5a / 307660	RGDID:	1549717	Length:	575	Species:	Rattus norvegicus

Alignment Length:	617	Identity:	172/617 - (27%)
Similarity:	291/617 - (47%)	Gaps:	122/617 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 TSSGPVRGRSVTVQGR--EVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQERY 109
            |..|.|:|:..||.||  .|:|:.|||:|.||:..|||..|.|..|||.:.:||.....|.|...
  Rat    35 TRLGWVQGKQATVLGRLEPVNVFLGIPFAAPPLGPLRFSNPQPPIPWHDLREATTYPNVCFQNLE 99

  Fly   110 EYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQN 174
            ..|...:..::..|...|||||||:|::|||.|                               |
  Rat   100 WLFIYQNLLKVHYPKLGVSEDCLYLNIYAPAYA-------------------------------N 133

  Fly   175 TTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEE 239
            ..:.||:::||.||||.||||:  |::...:||..:|::.:.|||:|.|||.:..       .:.
  Rat   134 DGSRLPVMMWIPGGGFETGSAS--IFDGSALAAYEDVLIVTIQYRLGIFGFFNTQ-------NQH 189

  Fly   240 APGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGT 304
            ||||....||..|::|:::|.:.|||||:.:|:||.|||:.|:::.::||::.||..|.:||||.
  Rat   190 APGNWAFQDQLAALQWVRENINYFGGNPDSVTIFGGSAGAISISSLILSPLSAGLFHRAIMQSGV 254

  Fly   305 MNAPWSHMTSEKAVEIGKALIND-CNCNASMLKTNPAHVMSCMR---SVDAKTISVQQWNSYSGI 365
            ...| |....:..::.|..::.| |.||.|..|.    ::.|:|   |::..::. |:..:::.:
  Rat   255 AIIP-SLKNFDDELKHGLQVVADVCKCNVSDSKV----LLKCLREKSSLELLSLG-QKTKAFTRV 313

  Fly   366 LSFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFL-LYDFID-YFDKDDATAL-- 426
                    :||:|.|.:||.|:.....|....::|....|..|.| :.:..: .|..:::|||
  Rat   314 --------VDGSFFPEEPMELLSQKTFKTVPSIIGVNNQECGYILPMREAPEILFGSNESTALTL 370

  Fly   427 --------PRDKYLEIMNNIFGKATQAE-REAIIFQYTSWEGNPGYQNQQQIGRAVGDHFFTCPT 482
                    |:..::...:...||.:..: |:.::..:                   ||.||..|.
  Rat   371 IHVLLHIPPQYMHIVAKDYFHGKHSLTDIRDTLLDLF-------------------GDVFFVVPG 416

  Fly   483 NEYAQALAERGASVHYYYFTHRTS--TSLWGEWMGVLHGDEIEYFFGQPL--NNSLQYRPV---E 540
            ...|:...:.|..|::|.|.||.:  .:....::...|.|||.:.||.|.  .:.:.:...   |
  Rat   417 LVTARNHRDAGGPVYFYEFQHRPNCFQNTRPAFVKADHTDEIRFVFGGPFLEGDVVMFEEATEDE 481

  Fly   541 RELGKRMLSAVIEFAKTGNPAQDGEE---WPNFSKEDPVYYI---FSTDDKIEKLARGPLAARCS 599
            :.|.::|:|....||::|:|  :|::   ||.:.:.:....:   .||..:::.       .|..
  Rat   482 KLLSRKMMSYWANFARSGDP--NGDDLPLWPAYDQNESYLKLDVNISTGWRLKD-------RRVE 537

  Fly   600 FWNDYLPKVRSWAGTCDGDSGSASISPRLQLL 631
            ||.|.||.:.|        :..|.:||...|:
  Rat   538 FWTDTLPLITS--------ASKALLSPTFPLI 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	162/585 (28%)
Ces5a	NP_001012056.2	Esterase_lipase	40..529	CDD:238191	159/563 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810