DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and Ces1e

DIOPT Version :9

Sequence 1:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_113753.2	Gene:	Ces1e / 29225	RGDID:	621508	Length:	561	Species:	Rattus norvegicus

Alignment Length:	601	Identity:	166/601 - (27%)
Similarity:	274/601 - (45%)	Gaps:	115/601 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 VVQTSSGPVRGRSVTVQG--REVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQ 106
            ||.|..|.|.|:.|:::|  :.|.|:.|:|:||||:..|||..|.|||||..|.:.|.....|.|
  Rat    25 VVDTLQGKVLGKYVSLEGFTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQ 89

  Fly   107 ERYEYFPGFSGEEIWNPNTN--------VSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADT 163
            :      ..:|:.:.:..||        .||||||:|::.||....|
  Rat    90 D------PVAGQIVNDLLTNREENISLQFSEDCLYLNIYTPADLTKR------------------ 130

  Fly   164 DHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHL 228
                         :.||:::||:|||.:.|.|:  .|:...::...||:|...|||:|.:||.
  Rat   131 -------------DRLPVMVWIHGGGLVLGGAS--TYDGLALSTHENVVVVVIQYRLGIWGFF-- 178

  Fly   229 APEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRG 293
                 |...|.:.||.|..||..|:.|::||...|||:|..:|:||||||..||:..::||:.:.
  Rat   179 -----STGDEHSRGNWGHLDQVAALHWVQDNIDNFGGDPGSVTIFGESAGGESVSVLVLSPLAKN 238

  Fly   294 LVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRSVDAKTI--SV 356
            |..:.:.:||..........:.:.:....|:::.|.      .|..|.::.|:|....:.:  :.
  Rat   239 LFHKAISESGVALTAGLVKKNTRPLAEKIAVVSGCK------STTSAAMVHCLRQKTEEELLETT 297

  Fly   357 QQWNSYSGIL------SFPSAPTI-DGAFLPADPMTLMKTADLKDYDILMG-NVRDEGTYFLLYD 413
            .:.|.:|..|      |:|..||: ||..||..|..::...|......::| |.::.|  ::|..
  Rat   298 LKLNLFSLDLHGDSRQSYPFVPTVLDGVVLPKMPEEILAEKDFNTVPYIVGINKQEFG--WILPT 360

  Fly   414 FIDYFDKDDATALPRDKYLEIM--NNIFGKAT---QAEREAI---IFQYTSWEGNPGYQNQQQIG 470
            .::|        .|.|..|:.|  .::..|::   ....|||   :.:|.....:|. :|:.|:.
  Rat   361 MMNY--------PPSDMKLDPMTATSLLKKSSFLLNLPEEAIPVAVEKYLRHTDDPD-RNKDQLL 416

  Fly   471 RAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTS-------TSLWGEWMGVLHGDEIEYFFGQ 528
            ..:||..|..|:...::...:.||..:.|.|.:|.|       :::.|:     |||||...||.
  Rat   417 ELIGDVIFGVPSVIVSRGHRDAGARTYMYEFQYRPSFSSKMKPSTVVGD-----HGDEIYSVFGA 476

  Fly   529 PL---NNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDG-EEWPNFSKEDPVYYIFSTDDKIEKL 589
            |:   ..|.:    |..|.|.|:.....||:.|||...| ..||.:.:::....|.:|..:.:||
  Rat   477 PILRGGTSKE----EINLSKMMMKFWANFARNGNPNGQGLPHWPEYDQKEGYLQIGATTQQAQKL 537

  Fly   590 ARGPLAARCSFWNDYL 605
            ....:|    ||::.|
  Rat   538 KEKEVA----FWSELL 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	163/595 (27%)
Ces1e	NP_113753.2	COesterase	24..545	CDD:278561	163/595 (27%)
		Aes	43..>239	CDD:223730	79/241 (33%)
		Prevents secretion from ER (Potential)	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810