DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and Ces2i

DIOPT Version :9

Sequence 1:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_008758816.2	Gene:	Ces2i / 292152	RGDID:	1565045	Length:	558	Species:	Rattus norvegicus

Alignment Length:	614	Identity:	175/614 - (28%)
Similarity:	274/614 - (44%)	Gaps:	113/614 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 CGVIDRLVVQ-------------TSSGPVRGRSVTVQGRE--VHVYTGIPYAKPPVEDLRFRKPV 86
            ||::  |::|             |.:|.|||..|.|:..:  ||.:.|||:|||||..|.|..|.
  Rat    15 CGLL--LLLQHVHGQDSASPIRNTQTGQVRGSFVHVKDTKSGVHTFLGIPFAKPPVGPLHFAPPE 77

  Fly    87 PAEPWHGVLDATRLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGAN 151
            ..|||.||.|.|.....|:|............::....|.:||||||:|::.||.||    .|:|
  Rat    78 DPEPWSGVRDGTSQPDMCLQTDIMKEDFIKEMKLTMHPTPMSEDCLYLNIYTPAHAR----EGSN 138

  Fly   152 GGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASF 216
                                       ||:::||:|||.:.|||::::  |..:||...:::.:.
  Rat   139 ---------------------------LPVMVWIHGGGLVLGSASMNV--ASTLAATEEIVIVAI 174

  Fly   217 QYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSS 281
            |||:|..||.       |...|.|.||.|..||..|:.|::.|...||||...:|:||.|||.:|
  Rat   175 QYRLGILGFF-------STGDEHARGNWGYLDQVAALCWVQQNIAYFGGNHGKVTIFGVSAGGTS 232

  Fly   282 VNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCM 346
            |::.::||:::||....:||||....|  .:.|:.:..:.|.:.|...|.||    :...::.|:
  Rat   233 VSSHVVSPMSKGLFHGAIMQSGVALLP--DLISDTSEVVYKTVANLSGCEAS----DSEALIRCL 291

  Fly   347 RSVDAKTISV--QQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNVRDE-GTY 408
            |:...:.|..  |.:....|:        :||.|||..|..|:.:.|......::|...|| |..
  Rat   292 RAKSKQEILAINQVFKMIPGV--------VDGKFLPKHPQELLASGDFHPVPSIIGVNTDECGLG 348

  Fly   409 FLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAER-------EAIIFQYTSWEGNPGYQNQ 466
            ..::..:|:..|    .:.||....::     |:|.|:.       :.|:.:|.....:| ...|
  Rat   349 VPMFMGLDHIIK----KITRDTLPTVL-----KSTAAQMMLPPECIDLIMEEYMGDTEDP-ETLQ 403

  Fly   467 QQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTS--TSLWGEWMGVLHGDEI-----EY 524
            :|....:||..|..|..|.|. .....|.|::|.|.|..|  ..:....:...|||:|     .|
  Rat   404 EQFKEMLGDFMFVIPALEVAH-FQRSQAPVYFYEFQHLPSFIKQVRPSHVKADHGDDILFVFSSY 467

  Fly   525 FFGQPLNNSLQYRPVERE--LGKRMLSAVIEFAKTGNP-AQDGEEWPNFSKEDPVYYIFSTDDKI 586
            |:|      :.:...|.|  |.:|::.....||:.||| ::|...||.....:. |...:|...:
  Rat   468 FWG------MNFDITEEEELLKRRVMKYWANFARNGNPNSEDLPYWPVLDHNEQ-YLQLNTQPAV 525

  Fly   587 EKLARGPLAARCSFWNDYLP-KVRSWAGT 614
               .|...|.|..||...|| |::...|:
  Rat   526 ---GRALKARRLQFWTKTLPQKIQELKGS 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	167/594 (28%)
Ces2i	XP_008758816.2	COesterase	30..537	CDD:395084	165/581 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810