Protein Alignment Ace and Ces4a

DIOPT Version :10

• Sequence 1: NP_476953.1
• Gene: Ace / 41625
• FlyBaseID: FBgn0000024
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001099646.1
• Gene: Ces4a / 291955
• RGDID: 1307418
• Length: 563
• Species: Rattus norvegicus
• Alignment Length: 648
• Identity: 179/648 - (27%)
• Similarity: 282/648 - (43%)
• Gaps: 160/648 - (24%)

  Fly    13 MSLPLPLTIPLPLVLVLSLHLSGVCGVIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPV 77
            |...|.|::.|.||:..:|   |.....:.|:: |..|.::|:.|.|....:.|:.|:|:::|||
  Rat     8 MKWTLDLSLTLWLVVQTAL---GALHTKEPLLI-TKHGILQGKQVHVGDTPIRVFLGVPFSQPPV 68

  Fly    78 EDLRFRKPVPAEPWHGVLDATRLSATCVQE--------------RYEYFPGFSGEEIWNPNTNVS 128
            ...||..|.|..||:|:.|||....:|:||              :||:.             :.|
  Rat    69 GTRRFAPPEPPLPWNGIRDATTYPPSCLQESWGQITSMYLNTRKQYEWL-------------HFS 120

  Fly   129 EDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTG 193
            |||||:||:||..|                          .|:|.     ||:::|..||.|:.|
  Rat   121 EDCLYLNVYAPVLA--------------------------PGDPL-----LPVMVWFPGGAFLVG 154

  Fly   194 SATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKD 258
            ||:  .|....:||.|.|::...|||:|..||.       |.....|.||.||.||..|:||:::
  Rat   155 SAS--TYEGSELAARGKVVLVFLQYRLGILGFF-------STGNSHARGNWGLLDQIAALRWVQE 210

  Fly   259 NAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGT--MNAPWSHMTSEKAVEIG 321
            |..||||:|:.:||||:|||:.||:..||||:.:||..:.:.||||  :....:|...:.|.:|
  Rat   211 NIEAFGGDPDSVTLFGQSAGAMSVSGLLMSPLAQGLFHQAISQSGTAVLKTFITHDPLKSAKKI- 274

  Fly   322 KALINDCNCNASMLKTNPAHVMSCMRSVDA-------KTISVQQWNSY---SGILSFPSAPTIDG 376
             |.:..|:.|::.:      ::.|::::.|       |.::..:.||:   ..|:.|.| |.:||
  Rat   275 -AHLAGCDHNSTKI------MVKCLKALPAEKVMLVSKKMTFFRANSHKDPKDIVWFLS-PVVDG 331

  Fly   377 AFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGK 441
            ...|.||:.|:....:|....|:|....|..:                :||....|::...|..|
  Rat   332 LVFPEDPVVLLTRGQVKPVPYLLGVNSAEFEW----------------SLPFLMKLQLNQRIMNK 380

  Fly   442 ---------------ATQAEREAIIFQYTS-------WEGNPGYQNQQQIGRAVGDHFFTCPTNE 484
                           .|:.:...:..:|.|       |:     ..:..:...|||..|...|.:
  Rat   381 NYITKLLWSCSILLNITEEQIPLVAREYLSDAISHHDWK-----MFRNHLIDLVGDATFVYATLQ 440

  Fly   485 YAQALAERGASVHYYYFTHRTSTSLWGEWMGVL---------HGDEIEYFFGQPLNNSLQYRPVE 540
            .|:...:.|:.|:.|.|.|...        |::         ||||:.|.||.|.:.. ..|..|
  Rat   441 AARYHRDAGSPVYLYEFKHHAP--------GIIVKPRSDGADHGDELSYLFGSPFSKG-SSRGEE 496

  Fly   541 RELGKRMLSAVIEFAKTGNPAQDGE--EWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFW 601
            :|...:|:.....||.||:| .|.|  .||.|.||:. |.....|.::....|   ..:.:||
  Rat   497 KEFSLQMMKYWANFAHTGDP-NDRELPYWPRFDKEEK-YLQLDFDTRVGVKLR---EKQMTFW 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_476953.1	COesterase	43..601	CDD:395084	169/616 (27%)
Ces4a	NP_001099646.1	COesterase	33..554	CDD:395084	169/618 (27%)