DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and Ces4a

DIOPT Version :9

Sequence 1:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001099646.1	Gene:	Ces4a / 291955	RGDID:	1307418	Length:	563	Species:	Rattus norvegicus

Alignment Length:	648	Identity:	179/648 - (27%)
Similarity:	282/648 - (43%)	Gaps:	160/648 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 MSLPLPLTIPLPLVLVLSLHLSGVCGVIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPV 77
            |...|.|::.|.||:..:|   |.....:.|:: |..|.::|:.|.|....:.|:.|:|:::|||
  Rat     8 MKWTLDLSLTLWLVVQTAL---GALHTKEPLLI-TKHGILQGKQVHVGDTPIRVFLGVPFSQPPV 68

  Fly    78 EDLRFRKPVPAEPWHGVLDATRLSATCVQE--------------RYEYFPGFSGEEIWNPNTNVS 128
            ...||..|.|..||:|:.|||....:|:||              :||:.             :.|
  Rat    69 GTRRFAPPEPPLPWNGIRDATTYPPSCLQESWGQITSMYLNTRKQYEWL-------------HFS 120

  Fly   129 EDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTG 193
            |||||:||:||..|                          .|:|.     ||:::|..||.|:.|
  Rat   121 EDCLYLNVYAPVLA--------------------------PGDPL-----LPVMVWFPGGAFLVG 154

  Fly   194 SATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKD 258
            ||:  .|....:||.|.|::...|||:|..||.       |.....|.||.||.||..|:||:::
  Rat   155 SAS--TYEGSELAARGKVVLVFLQYRLGILGFF-------STGNSHARGNWGLLDQIAALRWVQE 210

  Fly   259 NAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGT--MNAPWSHMTSEKAVEIG 321
            |..||||:|:.:||||:|||:.||:..||||:.:||..:.:.||||  :....:|...:.|.:|
  Rat   211 NIEAFGGDPDSVTLFGQSAGAMSVSGLLMSPLAQGLFHQAISQSGTAVLKTFITHDPLKSAKKI- 274

  Fly   322 KALINDCNCNASMLKTNPAHVMSCMRSVDA-------KTISVQQWNSY---SGILSFPSAPTIDG 376
             |.:..|:.|::.:      ::.|::::.|       |.::..:.||:   ..|:.|.| |.:||
  Rat   275 -AHLAGCDHNSTKI------MVKCLKALPAEKVMLVSKKMTFFRANSHKDPKDIVWFLS-PVVDG 331

  Fly   377 AFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGK 441
            ...|.||:.|:....:|....|:|....|..:                :||....|::...|..|
  Rat   332 LVFPEDPVVLLTRGQVKPVPYLLGVNSAEFEW----------------SLPFLMKLQLNQRIMNK 380

  Fly   442 ---------------ATQAEREAIIFQYTS-------WEGNPGYQNQQQIGRAVGDHFFTCPTNE 484
                           .|:.:...:..:|.|       |:     ..:..:...|||..|...|.:
  Rat   381 NYITKLLWSCSILLNITEEQIPLVAREYLSDAISHHDWK-----MFRNHLIDLVGDATFVYATLQ 440

  Fly   485 YAQALAERGASVHYYYFTHRTSTSLWGEWMGVL---------HGDEIEYFFGQPLNNSLQYRPVE 540
            .|:...:.|:.|:.|.|.|...        |::         ||||:.|.||.|.:.. ..|..|
  Rat   441 AARYHRDAGSPVYLYEFKHHAP--------GIIVKPRSDGADHGDELSYLFGSPFSKG-SSRGEE 496

  Fly   541 RELGKRMLSAVIEFAKTGNPAQDGE--EWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFW 601
            :|...:|:.....||.||:| .|.|  .||.|.||:. |.....|.::....|   ..:.:||
  Rat   497 KEFSLQMMKYWANFAHTGDP-NDRELPYWPRFDKEEK-YLQLDFDTRVGVKLR---EKQMTFW 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	169/618 (27%)
Ces4a	NP_001099646.1	COesterase	33..554	CDD:395084	169/618 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810