Protein Alignment Ace and CES4A

DIOPT Version :9

• Sequence 1: NP_001163600.1
• Gene: Ace / 41625
• FlyBaseID: FBgn0000024
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: XP_011521323.1
• Gene: CES4A / 283848
• HGNCID: 26741
• Length: 628
• Species: Homo sapiens
• Alignment Length: 730
• Identity: 183/730 - (25%)
• Similarity: 284/730 - (38%)
• Gaps: 255/730 - (34%)

  Fly     8 SRVLPMSLPLPLTIP-------LPLVLVLSLHLSGVCGVIDRLVVQTSSGPVRGRSV-------T 58
            |.||| |..||..:|       :..:|..||.|   |     |:.||:.|.:..:..       |
Human     3 STVLP-STVLPSLLPTAGAGWSMRWILCWSLTL---C-----LMAQTALGALHTKRPQVVTKYGT 58

  Fly    59 VQGREVH-------VYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDAT------------------ 98
            :||:::|       |:.|:|:::||:..|||..|.|.|||.|:.|||
Human    59 LQGKQMHVGKTPIQVFLGVPFSRPPLGILRFAPPEPPEPWKGIRDATTYPPGWSLALSPGWSAVA 123

  Fly    99 --RLSAT--------------------CVQ--------------ERYEYFPGFSGEEIWNPNTNV 127
              ||:||                    |:|              |||::.             ..
Human   124 RSRLTATSASRVQASLLPQPLSIWGYRCLQESWGQLASMYVSTRERYKWL-------------RF 175

  Fly   128 SEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMT 192
            ||||||:||:|||:|                          .|:||     ||:::|..||.|:.
Human   176 SEDCLYLNVYAPARA--------------------------PGDPQ-----LPVMVWFPGGAFIV 209

  Fly   193 GSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLK 257
            |:|:  .|....:||...|::...|:|:|.||||..........|.   ||.||.||..|:||::
Human   210 GAAS--SYEGSDLAAREKVVLVFLQHRLGIFGFLRWRGRTDDSHAR---GNWGLLDQMAALRWVQ 269

  Fly   258 DNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGK 322
            :|..||||:|..:||||:|||:.|::..:|||:..||..|.:.||||  |.:....:...:::.|
Human   270 ENIAAFGGDPGNVTLFGQSAGAMSISGLMMSPLASGLFHRAISQSGT--ALFRLFITSNPLKVAK 332

  Fly   323 --ALINDCNCNASMLKTNPAHVMSCMRSVD-AKTISVQQWNSYSGI--------LSFPSAPTIDG 376
              |.:..||.|::.:..|      |:|::. .|.:.|.....:..:        :.:..:|.:||
Human   333 KVAHLAGCNHNSTQILVN------CLRALSGTKVMRVSNKMRFLQLNFQRDPEEIIWSMSPVVDG 391

  Fly   377 AFLPADPMTLMKTADLKDYDILMG---------------------------------------NV 402
            ..:|.||:.|:....:.....|:|                                       |:
Human   392 VVIPDDPLVLLTQGKVSSVPYLLGVNNLEFNWLLPYIMKFPLNRQAMRKETITKMLWSTRTLLNI 456

  Fly   403 RDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGNPGYQNQQ 467
            ..|....::.:::|..::.|...| |::.::|
Human   457 TKEQVPLVVEEYLDNVNEHDWKML-RNRMMDI--------------------------------- 487

  Fly   468 QIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTH---------RTSTSLWGEWMGVLHGDEIE 523
                 |.|..|...|.:.|....:.|..|:.|.|.|         ||.        |..||||:.
Human   488 -----VQDATFVYATLQTAHYHRDAGLPVYLYEFEHHARGIIVKPRTD--------GADHGDEMY 539

  Fly   524 YFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDGEE--WPNFSKEDPVYYIFSTDDKI 586
            :.||.|....|.... |:.|..:|:.....||:|||| .||..  ||.::|::....:..|....
Human   540 FLFGGPFATGLSMGK-EKALSLQMMKYWANFARTGNP-NDGNLPCWPRYNKDEKYLQLDFTTRVG 602

  Fly   587 EKLARGPLAARCSFW 601
            .||....:|    ||
Human   603 MKLKEKKMA----FW 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	168/688 (24%)
CES4A	XP_011521323.1	COesterase	46..613	CDD:278561	164/676 (24%)
		Aes	<184..>291	CDD:223730	49/142 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810