Protein Alignment Ace and Ces2c

DIOPT Version :10

• Sequence 1: NP_476953.1
• Gene: Ace / 41625
• FlyBaseID: FBgn0000024
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_663578.1
• Gene: Ces2c / 234671
• MGIID: 2385905
• Length: 561
• Species: Mus musculus
• Alignment Length: 613
• Identity: 159/613 - (25%)
• Similarity: 262/613 - (42%)
• Gaps: 114/613 - (18%)

  Fly    26 VLVLSLHLSGVCGVIDRLVVQTSSGPVRGRSVTVQGRE--VHVYTGIPYAKPPVEDLRFRKPVPA 88
            :|:|.:|:.|........:..|.:|.::|..:.|:..:  ||.:.|||:|||||..|||..|...
Mouse    17 LLLLLIHVQGQDSPEANPIRNTHTGQIQGSLIHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAP 81

  Fly    89 EPWHGVLDATRLSATCVQE--------------RYEYFPGFSGEEIWNPNTNVSEDCLYINVWAP 139
            |||.||.|.|...|.|:|.              ....||             :||||||:|::.|
Mouse    82 EPWSGVRDGTAHPAMCLQNLDMLNEAGLPDMKMMLSSFP-------------MSEDCLYLNIYTP 133

  Fly   140 AKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADI 204
            |.|                         |.|      :.||:::||:||..:.|.|::  ::..:
Mouse   134 AHA-------------------------HEG------SNLPVMVWIHGGALVIGMASM--FDGSL 165

  Fly   205 MAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEW 269
            :....:::|.:.|||:|..||.       |...:.|.||.|..|||.|:||::.|...|||||:.
Mouse   166 LTVNEDLVVVTIQYRLGVLGFF-------STGDQHARGNWGYLDQAAALRWVQQNIAHFGGNPDR 223

  Fly   270 MTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASM 334
            :|:||||||.:||::.::||:::||....:|:||....|  .:.||.:..:...:.....|.|
Mouse   224 VTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVALLP--DLISETSEMVSTTVAKLSGCEA-- 284

  Fly   335 LKTNPAHVMSCMR-SVDAKTISVQQWNSYSGILSFPSAP-TIDGAFLPADPMTLMKTADLKDYDI 397
              .:...::.|:| ..:|:.:::.:        .|...| .:||.|.|..|..|:.:.|......
Mouse   285 --MDSQALVRCLRGKSEAEILAINK--------VFKMIPAVVDGEFFPRHPKELLASEDFHPVPS 339

  Fly   398 LMGNVRDEGTYFL-----LYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSW 457
            ::|...||..:.:     ....|....:::..|:.:|..:::|       ...|...::.:....
Mouse   340 IIGVNNDEFGWSIPVVMGSAQMIKGITRENLQAVLKDTAVQMM-------LPPECSDLLMEEYMG 397

  Fly   458 EGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTS--TSLWGEWMGVLHGD 520
            :.......|.|....:||..|..|..:.|. .....|.|::|.|.|..|  ..:....:...|.|
Mouse   398 DTEDAQTLQIQFTEMMGDFMFVIPALQVAH-FQRSHAPVYFYEFQHPPSYFKDVRPPHVKADHAD 461

  Fly   521 EI-----EYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDG-EEWPNFSKEDPVYYI 579
            ||     .:|:|.    .|.:...|..|.:||:.....||:.|||..:| ..||....::....:
Mouse   462 EIPFVFASFFWGM----KLDFTEEEELLSRRMMKYWANFARHGNPNSEGLPYWPVMDHDEQYLQL 522

  Fly   580 FSTDDKIEKLARGPLAARCSFWNDYLPK 607
                |....:.|...|.|..||...||:
Mouse   523 ----DIQPAVGRALKAGRLQFWTKTLPQ 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_476953.1	COesterase	43..601	CDD:395084	151/588 (26%)
Ces2c	NP_663578.1	COesterase	32..540	CDD:395084	151/590 (26%)
		Prevents secretion from ER. /evidence=ECO:0000255	558..561