Protein Alignment Ace and NLGN1

DIOPT Version :9

• Sequence 1: NP_001163600.1
• Gene: Ace / 41625
• FlyBaseID: FBgn0000024
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Alignment Length: 652
• Identity: 179/652 - (27%)
• Similarity: 289/652 - (44%)
• Gaps: 97/652 - (14%)

  Fly    15 LPLPLTIPLPLVLVLSLH-LSGVCGVIDRLVVQTSSGPVRGRSVTVQGR---EVHVYTGIPYAKP 75
            |..|||:.:...|:.:.| ||.....:|.||. |:.|.:||....:...   .|..:.|:|||.|
Human    25 LGAPLTLCMLGCLLQAGHVLSQKLDDVDPLVA-TNFGKIRGIKKELNNEILGPVIQFLGVPYAAP 88

  Fly    76 PVEDLRFRKPVPAEPWHGVLDATRLSATCVQERYEYFPGFSGE---EIWNPNT---------NVS 128
            |..:.||:.|.|..||..:.:||:.:..|.|   ....|...|   .:|..|.         :.|
Human    89 PTGERRFQPPEPPSPWSDIRNATQFAPVCPQ---NIIDGRLPEVMLPVWFTNNLDVVSSYVQDQS 150

  Fly   129 EDCLYINVWAPAK-----ARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGG 188
            |||||:|::.|.:     .:.....|.|.|       |:.:.:..:|.|:      |::::|:||
Human   151 EDCLYLNIYVPTEDGPLTKKQTDDLGDNDG-------AEDEDIRDSGGPK------PVMVYIHGG 202

  Fly   189 GFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAI 253
            .:|.|:..|  |:..::|:.|||||.:..||:|..|||       |...:.|.||.||.|...|:
Human   203 SYMEGTGNL--YDGSVLASYGNVIVITVNYRLGVLGFL-------STGDQAAKGNYGLLDLIQAL 258

  Fly   254 RWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPV---------TRGLVKRGMMQSGTMNAPW 309
            ||..:|...|||:|..:|:||..||.|.||...:|..         |:||.:|.:.||||..:.|
Human   259 RWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSW 323

  Fly   310 SHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTI 374
            :  .|.:..:..:.|.....||.|    :...::.|::....|.:..|........::|  .|.|
Human   324 A--VSFQPAKYARMLATKVGCNVS----DTVELVECLQKKPYKELVDQDIQPARYHIAF--GPVI 380

  Fly   375 DGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYL--EIMNN 437
            ||..:|.||..||:..:..:|||::|..:.||..|:    .:..|.||..:.....:.  ..::|
Human   381 DGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFV----ENIVDSDDGISASDFDFAVSNFVDN 441

  Fly   438 IFG--KATQAEREAIIFQYTSWEGNPGYQNQQQIGRAV-GDHFFTCPTNEYAQALAERGASVHYY 499
            ::|  :.....||.|.|.||.|......:.:::...|: .||.:..|....|...:..|:..::|
Human   442 LYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFY 506

  Fly   500 YFTHRTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVI-----EFAKTGN 559
            .|.|...|.....|....||||:.|..|.|:....:..|........|||||:     .|||||:
Human   507 AFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGD 571

  Fly   560 PAQ----------------DGEEWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKV 608
            |.|                :...|..:|::|.:|.......::::..|   |.:.:.|.:.:|.:
Human   572 PNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYR---ANKVNLWLELVPHL 633

  Fly   609 RS 610
            .:
Human   634 HN 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	169/614 (28%)
NLGN1	NP_001352852.1	COesterase	53..626	CDD:365897	168/613 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910