Protein Alignment Ace and NLGN4Y

DIOPT Version :9

• Sequence 1: NP_001163600.1
• Gene: Ace / 41625
• FlyBaseID: FBgn0000024
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001352513.1
• Gene: NLGN4Y / 22829
• HGNCID: 15529
• Length: 836
• Species: Homo sapiens
• Alignment Length: 611
• Identity: 176/611 - (28%)
• Similarity: 286/611 - (46%)
• Gaps: 82/611 - (13%)

  Fly    44 VVQTSSGPVRGRSVTVQGR---EVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCV 105
            ||.|:.|.::|....:...   .|..|.|:|||.||..:.||:.|.....|.|:.:||:.||.|.
Human    47 VVNTNYGKIQGLRTPLPSEILGPVEQYLGVPYASPPTGERRFQPPESPSSWTGIRNATQFSAVCP 111

  Fly   106 QERYEYFPGFSGEEIWNPNT---------NVSEDCLYINVWAPAKARLRHGRGAN---GGEHPNG 158
            |...|.|.......||...:         :.:|||||:|::.|.:......|.|:   ..:|  |
Human   112 QHLDERFLLHDMLPIWFTTSLDTLMTYVQDQNEDCLYLNIYVPMEDGTNIKRNADDITSNDH--G 174

  Fly   159 KQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAF 223
            :..|    ||..|.:.     |::::|:||.:|.|  |.::.:..|:|:.|||||.:..||:|..
Human   175 EDKD----IHEQNSKK-----PVMVYIHGGSYMEG--TGNMIDGSILASYGNVIVITINYRLGIL 228

  Fly   224 GFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMS 288
            |||       |...:.|.||.||.||..|:||:::|..||||:|:.:|:||..||:|.|:...:|
Human   229 GFL-------STGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLS 286

  Fly   289 PVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRSVDAKT 353
            ..:.||.::.::||||..:.|:  .:.:..:..:.|.:...||  ||.|  ..::.|:::.:.|.
Human   287 HYSEGLFQKAIIQSGTALSSWA--VNYQPAKYTRILADKVGCN--MLDT--TDMVECLKNKNYKE 345

  Fly   354 ISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLLYDFID-Y 417
            :..|.....:..::|  .|.|||..:|.||..||:..:..:|||::|..:.||     ..|:| .
Human   346 LIQQTITPATYHIAF--GPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEG-----LKFVDGI 403

  Fly   418 FDKDDATALPRDKYLEIMN---NIFG--KATQAEREAIIFQYTSW--EGNPGYQNQQQIGRAVGD 475
            .|.:|... |.|....:.|   |::|  :.....||.|.|.||.|  :.||..:.:..:. ...|
Human   404 VDNEDGVT-PNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVA-LFTD 466

  Fly   476 HFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVE 540
            |.:..|....|...|:.|:..::|.|.|...:.:...|....||||:.|.||.|:....:.....
Human   467 HQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCN 531

  Fly   541 RELGKRMLSAVI-----EFAKTGNPAQ----------------DGEEWPNFSKEDPVYYIFSTDD 584
            ......|||||:     .|||||:|.|                :...|..::.:|.:|.......
Human   532 FSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKP 596

  Fly   585 KIEKLARGPLAARCSFWNDYLPKVRS 610
            ::....|   |.:.:||.:.:|.:.:
Human   597 RVRDHYR---ATKVAFWLELVPHLHN 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	173/600 (29%)
NLGN4Y	NP_001352513.1	COesterase	46..610	CDD:306613	173/600 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910