Protein Alignment Ace and CES5A

DIOPT Version :9

• Sequence 1: NP_001163600.1
• Gene: Ace / 41625
• FlyBaseID: FBgn0000024
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001177087.1
• Gene: CES5A / 221223
• HGNCID: 26459
• Length: 604
• Species: Homo sapiens
• Alignment Length: 624
• Identity: 170/624 - (27%)
• Similarity: 278/624 - (44%)
• Gaps: 113/624 - (18%)

  Fly    47 TSSGPVRGRSVTVQGR--EVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQERY 109
            |..|.::|:.|||.|.  .|:|:.|:|:|.||:..|||..|.||.||..:.:||.....|:|...
Human    64 TRLGWIQGKQVTVLGSPVPVNVFLGVPFAAPPLGSLRFTNPQPASPWDNLREATSYPNLCLQNSE 128

  Fly   110 EYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQN 174
            .........::..|...|||||||:|::|||.|                               :
Human   129 WLLLDQHMLKVHYPKFGVSEDCLYLNIYAPAHA-------------------------------D 162

  Fly   175 TTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEE 239
            |.:.||:|:|..||.|.||||:  |::...:||..:|:|...|||:|.|||.       :.:.:.
Human   163 TGSKLPVLVWFPGGAFKTGSAS--IFDGSALAAYEDVLVVVVQYRLGIFGFF-------TTWDQH 218

  Fly   240 APGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGT 304
            ||||....||..|:.|::.|...|||:|..:|:||||||:.||::.::||:.:||..:.:|:||.
Human   219 APGNWAFKDQVAALSWVQKNIEFFGGDPSSVTIFGESAGAISVSSLILSPMAKGLFHKAIMESGV 283

  Fly   305 MNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRSVDAK---TISVQQWNSYSGIL 366
            ...|:......:..|..:.:.:.|..|||    :...::.|:|:..:|   |:| |:..|::.:
Human   284 AIIPYLEAHDYEKSEDLQVVAHFCGNNAS----DSEALLRCLRTKPSKELLTLS-QKTKSFTRV- 342

  Fly   367 SFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLL-----YDFIDYFDKDDATAL 426
                   :||||.|.:|:.|:.....|....::| |.:....|||     .:.:...:|..|
Human   343 -------VDGAFFPNEPLDLLSQKAFKAIPSIIG-VNNHECGFLLPMKEAPEILSGSNKSLA--- 396

  Fly   427 PRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGNPGYQNQQQIGR-------AVGDHFFTCPTNE 484
                 |.::.||.         .|..||.....|..:.::..:..       .:||.||..|...
Human   397 -----LHLIQNIL---------HIPPQYLHLVANEYFHDKHSLTEIRDSLLDLLGDVFFVVPALI 447

  Fly   485 YAQALAERGASVHYYYFTHR------TSTSLWGEWMGVLHGDEIEYFFGQPL--NNSLQYRPV-- 539
            .|:...:.||.|::|.|.||      |..:    ::...|.||:.:.||...  .:.:.:...
Human   448 TARYHRDAGAPVYFYEFRHRPQCFEDTKPA----FVKADHADEVRFVFGGAFLKGDIVMFEGATE 508

  Fly   540 -ERELGKRMLSAVIEFAKTGNP-AQDGEEWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWN 602
             |:.|.::|:.....||:|||| ..|...||.::..:. |.....:..:.:..:.|   |..||.
Human   509 EEKLLSRKMMKYWATFARTGNPNGNDLSLWPAYNLTEQ-YLQLDLNMSLGQRLKEP---RVDFWT 569

  Fly   603 DYLPKVRSWAGTCDGDSGSASISPRLQLLGIAALIYICA 641
            ..:|.:.|.:........|.:....||     ...:.||
Human   570 STIPLILSASDMLHSPLSSLTFLSLLQ-----PFFFFCA 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	161/582 (28%)
CES5A	NP_001177087.1	COesterase	56..568	CDD:278561	161/582 (28%)
		Aes	<155..>258	CDD:223730	47/142 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810