Protein Alignment Ace and CES5A

DIOPT Version :10

• Sequence 1: NP_476953.1
• Gene: Ace / 41625
• FlyBaseID: FBgn0000024
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001177087.1
• Gene: CES5A / 221223
• HGNCID: 26459
• Length: 604
• Species: Homo sapiens
• Alignment Length: 624
• Identity: 170/624 - (27%)
• Similarity: 278/624 - (44%)
• Gaps: 113/624 - (18%)

  Fly    47 TSSGPVRGRSVTVQGR--EVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQERY 109
            |..|.::|:.|||.|.  .|:|:.|:|:|.||:..|||..|.||.||..:.:||.....|:|...
Human    64 TRLGWIQGKQVTVLGSPVPVNVFLGVPFAAPPLGSLRFTNPQPASPWDNLREATSYPNLCLQNSE 128

  Fly   110 EYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQN 174
            .........::..|...|||||||:|::|||.|                               :
Human   129 WLLLDQHMLKVHYPKFGVSEDCLYLNIYAPAHA-------------------------------D 162

  Fly   175 TTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEE 239
            |.:.||:|:|..||.|.||||:  |::...:||..:|:|...|||:|.|||.       :.:.:.
Human   163 TGSKLPVLVWFPGGAFKTGSAS--IFDGSALAAYEDVLVVVVQYRLGIFGFF-------TTWDQH 218

  Fly   240 APGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGT 304
            ||||....||..|:.|::.|...|||:|..:|:||||||:.||::.::||:.:||..:.:|:||.
Human   219 APGNWAFKDQVAALSWVQKNIEFFGGDPSSVTIFGESAGAISVSSLILSPMAKGLFHKAIMESGV 283

  Fly   305 MNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRSVDAK---TISVQQWNSYSGIL 366
            ...|:......:..|..:.:.:.|..|||    :...::.|:|:..:|   |:| |:..|::.:
Human   284 AIIPYLEAHDYEKSEDLQVVAHFCGNNAS----DSEALLRCLRTKPSKELLTLS-QKTKSFTRV- 342

  Fly   367 SFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLL-----YDFIDYFDKDDATAL 426
                   :||||.|.:|:.|:.....|....::| |.:....|||     .:.:...:|..|
Human   343 -------VDGAFFPNEPLDLLSQKAFKAIPSIIG-VNNHECGFLLPMKEAPEILSGSNKSLA--- 396

  Fly   427 PRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGNPGYQNQQQIGR-------AVGDHFFTCPTNE 484
                 |.::.||.         .|..||.....|..:.::..:..       .:||.||..|...
Human   397 -----LHLIQNIL---------HIPPQYLHLVANEYFHDKHSLTEIRDSLLDLLGDVFFVVPALI 447

  Fly   485 YAQALAERGASVHYYYFTHR------TSTSLWGEWMGVLHGDEIEYFFGQPL--NNSLQYRPV-- 539
            .|:...:.||.|::|.|.||      |..:    ::...|.||:.:.||...  .:.:.:...
Human   448 TARYHRDAGAPVYFYEFRHRPQCFEDTKPA----FVKADHADEVRFVFGGAFLKGDIVMFEGATE 508

  Fly   540 -ERELGKRMLSAVIEFAKTGNP-AQDGEEWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWN 602
             |:.|.::|:.....||:|||| ..|...||.::..:. |.....:..:.:..:.|   |..||.
Human   509 EEKLLSRKMMKYWATFARTGNPNGNDLSLWPAYNLTEQ-YLQLDLNMSLGQRLKEP---RVDFWT 569

  Fly   603 DYLPKVRSWAGTCDGDSGSASISPRLQLLGIAALIYICA 641
            ..:|.:.|.:........|.:....||     ...:.||
Human   570 STIPLILSASDMLHSPLSSLTFLSLLQ-----PFFFFCA 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_476953.1	COesterase	43..601	CDD:395084	161/582 (28%)
CES5A	NP_001177087.1	COesterase	58..568	CDD:395084	161/582 (28%)