DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and Ces2e

DIOPT Version :9

Sequence 1:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001093947.1	Gene:	Ces2e / 192257	RGDID:	621563	Length:	557	Species:	Rattus norvegicus

Alignment Length:	588	Identity:	169/588 - (28%)
Similarity:	266/588 - (45%)	Gaps:	89/588 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 TSSGPVRGRSVTVQGRE--VHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQERY 109
            |.:|.|||..|.|:..:  ||.:.|||:||||:..|||..|.|.|||.||.|.|...|.|:|.
  Rat    36 THTGQVRGSFVHVKDTKSGVHTFLGIPFAKPPIGPLRFAPPEPPEPWSGVRDGTSHPAMCLQN-- 98

  Fly   110 EYFPGFSGEEI-----WNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHN 169
              ..|.:.|.:     .:| .::||||||::::.||                           |.
  Rat    99 --IDGLNLENLKIKMSRSP-VSMSEDCLYLSIYTPA---------------------------HT 133

  Fly   170 GNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPS 234
            ....|    ||:::||:|||...|.|:  .|:..::||:.:|:|.:.|||:|..||.       |
  Rat   134 HKDSN----LPVMVWIHGGGLCWGMAS--TYDGSMLAAIEDVVVVTIQYRLGILGFF-------S 185

  Fly   235 EFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGM 299
            ...|.|.||.|..||..|:||::.|...|||||:.:|:||||||..||::.::||:::||....:
  Rat   186 TGDEHARGNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGISVSSHVVSPMSQGLFHGAI 250

  Fly   300 MQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRSVDAKTISVQQWNSYSG 364
            |:||....|  ::.|..:..|...:.|...|.    ..:...:|||:|..     |.::..:.:.
  Rat   251 MESGVALLP--NLISNTSEVIYTMVANLSGCE----PVDSEALMSCLREK-----SEEEMLAINN 304

  Fly   365 ILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDAT--ALP 427
            |:...|. .:||.|||..|:.|:.:.|......::|...||      |.:|......|:|  .:.
  Rat   305 IVRTISG-VVDGKFLPRHPLELLASVDFHPVPSIIGINSDE------YGWIIPMLHPDSTMKEIN 362

  Fly   428 RDKYLEIMNNIFGKATQ----AEREAIIFQYTSWEGNPGYQNQQQIGRAVGDHFFTCPTNEYAQA 488
            |:....::.|   .|.|    .|...::.:....:.......|.|....:||..|..|..:.|.
  Rat   363 RETMRAVLKN---TAVQMMLPPECSDLLMEEYMGDTEDSKTLQIQFNEMMGDFIFVIPALQVAH- 423

  Fly   489 LAERGASVHYYYFTHRTS--TSLWGEWMGVLHGDEIEYFFGQPL-NNSLQYRPVERELGKRMLSA 550
            .....|.|::|.|.|:::  ..:....:...||||:.|..|... :....:...|:.|.::|:..
  Rat   424 FQRSHAPVYFYEFQHQSNFLKDIRPPHVKADHGDELPYVIGYLFWDMKFVFTEEEKLLSRKMIKY 488

  Fly   551 VIEFAKTGNPAQDG-EEWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDYLP-KVRSWAG 613
            ...||:.|||..:| ..||....::....:    |....:.|...|.|..||...|| |::...|
  Rat   489 WANFARHGNPNSEGLPYWPALDHDEQYLQL----DIQPVVGRALKARRLKFWTKTLPQKIQELKG 549

  Fly   614 TCD 616
            :.|
  Rat   550 SQD 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	162/570 (28%)
Ces2e	NP_001093947.1	COesterase	30..536	CDD:278561	162/570 (28%)
Ces2e	NP_001093947.1	Aes	<127..>230	CDD:223730	47/142 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810