DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and cest-28

DIOPT Version :9

Sequence 1:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_504691.2	Gene:	cest-28 / 187305	WormBaseID:	WBGene00019654	Length:	548	Species:	Caenorhabditis elegans

Alignment Length:	589	Identity:	152/589 - (25%)
Similarity:	252/589 - (42%)	Gaps:	111/589 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQERY 109
            :..:.||::|....:..:.|..|.|||:|||.|   ||:||.||..|..|.|.|:....|.|.
Worm    17 LNATCGPIQGNVYRIGDKTVDGYLGIPFAKPLV---RFKKPEPAGTWEEVRDCTKYGPRCPQS-- 76

  Fly   110 EYFPGFSGEEIWNPNTNVSED--CLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNP 172
                |...|.|.....::.::  ||.:||::                    |.:|:
Worm    77 ----GPFAEAINFQKDDIPDEANCLTLNVFS--------------------KISDS--------- 108

  Fly   173 QNTTNGLPILIWIYGGGFMTGSATLDI--YNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSE 235
            :|.....|::::|:|||:.. ||:.|.  |:......:.:|:|.:..||||..||......:
Worm   109 KNFNKTRPVMVYIHGGGYEC-SASRDYCDYSVAGTLPLKDVVVVTLNYRVGILGFFTTGDTV--- 169

  Fly   236 FAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMM 300
                .|||..|||..|.:.|::.:..:|||:|..:|:||:|||::.|:...:||.:|.|..|.::
Worm   170 ----CPGNFALWDLTLGLNWIQKHIESFGGDPGNITIFGQSAGAACVDLLALSPHSRDLFNRVIV 230

  Fly   301 QSGTMNAPWSHMTSEKAVEIGKALINDCNCNASML---KTNPAHVMSCMRSVDAKTISVQQWNSY 362
            .||.....::..|:....::       |...|..|   .||...:.:.|:|...:  .:::.|.:
Worm   231 MSGGALCEYAVRTANSQAKV-------CYEFARHLGYDGTNSQTLFNWMKSKPLE--EIEKMNGF 286

  Fly   363 ----SGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDA 423
                ||||::  .|.:|..|.|.....|...|..|  ||:||....||.:|      ::..||..
Worm   287 QVPASGILAW--TPNLDDDFFPKSLDELRIGAPKK--DIMMGFAEHEGLFF------EFLIKDPT 341

  Fly   424 TALPRDKYLEIMNNIFGKAT----QAEREAII-FQYTSWEGNPGYQNQQQIGRAVGDHFFTCPTN 483
            ..|...|.  .:|..:.|.|    :|.|..|| |...:.|.......::::...|||..||....
Worm   342 PPLEALKL--YVNEYYKKDTGDHFEATRNKIIEFYSRNVEDTDEKSTKERLIDFVGDALFTAGVF 404

  Fly   484 EYAQALAERGASVHYYYFTHRTSTSLWGE-----WMGVLHGDEIEYFFGQPLNNSLQYRPVEREL 543
            :.|:...:.|.:|..|.|.:...:....:     ::...|..::.|..|:.|.:..|....|.::
Worm   405 DNAKNCLKHGNNVWLYIFDYCNPSGFGNQEEFMTFVAPTHCTDLRYVLGEGLYSDFQPTEEEHKM 469

  Fly   544 GKRMLSAVIEFAKTGNPAQDG-EEWPNFSKEDP-----VYYIFSTDDKIEKLARGPLAARCSFWN 602
            .::|.:....|||.|||.:.| .||..|:.::|     :.|           .||.:.      |
Worm   470 IEKMTTIYSNFAKYGNPNEHGSSEWEKFTLDNPRRHFQISY-----------PRGKMR------N 517

  Fly   603 DYLP 606
            ||.|
Worm   518 DYHP 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	148/582 (25%)
cest-28	NP_504691.2	COesterase	17..516	CDD:278561	148/576 (26%)
cest-28	NP_504691.2	Aes	<112..>222	CDD:223730	38/117 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810