Protein Alignment Ace and cest-3

DIOPT Version :10

• Sequence 1: NP_476953.1
• Gene: Ace / 41625
• FlyBaseID: FBgn0000024
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_510042.2
• Gene: cest-3 / 181385
• WormBaseID: WBGene00008451
• Length: 588
• Species: Caenorhabditis elegans
• Alignment Length: 594
• Identity: 119/594 - (20%)
• Similarity: 214/594 - (36%)
• Gaps: 204/594 - (34%)

  Fly    25 LVLVLSLHLSGVCGVIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAE 89
            ::.|.:|:.||      :.::.|:.|.:.|::|.|   :.|::..:|:||||:..|||..|....
 Worm    10 ILFVFTLNGSG------QRIISTTYGKLEGKTVNV---DQHMFKNVPFAKPPLGKLRFSLPEWTN 65

  Fly    90 PWHGVLDATRLSATC-----VQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRG 149
            ||..:.:||..|.:|     ::....:||             :||||||:||:.
 Worm    66 PWKNIRNATEYSPSCFSNSSMRTDSNFFP-------------MSEDCLYLNVFT----------- 106

  Fly   150 ANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSAT-------LDIYNADIMAA 207
                         .::.:.:.|       ...:::.:|||....||.       |:.|..:
 Worm   107 -------------NEYCLKSKN-------CSTVVYYHGGGINMDSAVQFNDTFILERYVKE---- 147

  Fly   208 VGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTL 272
              ||:.....||:|.||.|:....      ...|.|:.:.|..||:|::......|||:.:.:.|
 Worm   148 --NVVFIIPAYRLGIFGLLYFGSN------NLVPQNLAIHDCELALRFIHQEISNFGGHKDDINL 204

  Fly   273 FGESAGSSSVNAQLMSPVTR------GLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDC--- 328
            .|.|||:   :..|:...:|      .|:.|.::           ::...:.::.:.||.:|
 Worm   205 MGHSAGA---HISLIFGFSRHIDPDHKLINRIIV-----------LSPVPSYDMPELLIKNCYDF 255

  Fly   329 ----NCNASMLKTNPAHVMSCMRSVDAKTISVQQ----------WNSYSGILSFPSAPTIDGAFL 379
                .|....:......::.|:|..||:.:...|          ||                 ||
 Worm   256 AERVGCYKRNVTARDTEIVKCLRKKDARGLMSMQRLMENDRLYFWN-----------------FL 303

  Fly   380 PADPMTLM--KTADLKDY----DILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNI 438
            ..:|....  ..||.|:|    |:|:||..||                                :
 Worm   304 AGEPFMYRDESIADFKEYAVKRDMLIGNTVDE--------------------------------V 336

  Fly   439 FGKATQAEREAIIFQYTSWEGNPGYQNQQQIGRAVGDHFFTCPTNE---------------YAQA 488
            ..|..:.|..||...:..||      |..::......:..:.|.|.               ||:|
 Worm   337 KWKRLKKENPAIAGSFMDWE------NPYEVAHKFNFYHDSAPVNSTYESFTQGIFVSTATYAEA 395

  Fly   489 LAERGASVHYYYFTHRTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLS-AVI 552
            .|..|.:|:.:....:.|:          |..:::||.|   .:...|...:.::.....| .::
 Worm   396 QANAGGTVYLFQSNQQPSS----------HVSDMQYFVG---THREDYHTSDMDIMDTFYSKMIV 447

  Fly   553 EFAKTGNPA 561
            .|.|.|:|:
 Worm   448 NFTKFGSPS 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_476953.1	COesterase	43..601	CDD:395084	115/576 (20%)
cest-3	NP_510042.2	alpha/beta hydrolases	21..496	CDD:473884	115/577 (20%)