Protein Alignment Ace and cest-19

DIOPT Version :10

• Sequence 1: NP_476953.1
• Gene: Ace / 41625
• FlyBaseID: FBgn0000024
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_509187.4
• Gene: cest-19 / 180973
• WormBaseID: WBGene00020125
• Length: 607
• Species: Caenorhabditis elegans
• Alignment Length: 643
• Identity: 159/643 - (24%)
• Similarity: 251/643 - (39%)
• Gaps: 180/643 - (27%)

  Fly    32 HLSGVCGVIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLD 96
            ||:.....|....::.:||.:||..:...|::..|:.|||:|.|||..|||:.|.....|.||::
 Worm    15 HLTISTRHISPFELRVNSGAIRGERLLTDGQDYSVFKGIPFAMPPVGYLRFQMPKEPAKWRGVMN 79

  Fly    97 ATRLSATCVQ----------ERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGAN 151
            ||:.||.|:|          |||.              .:|||||||:||::|...
 Worm    80 ATQYSAMCMQNIDENDAGEPERYV--------------AHVSEDCLYLNVFSPTPY--------- 121

  Fly   152 GGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMA--AVGNVIVA 214
                                 |.|.:..|::::|:||.|.|||.: ||....|::  ....::..
 Worm   122 ---------------------QYTNDTYPVIVFIHGGRFQTGSGS-DIPQRAILSNFVSRKIVFV 164

  Fly   215 SFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGS 279
            :|.||:|..||......:       .|||:|||||..|::|:|.||..|||:|..:.|.|...|:
 Worm   165 TFNYRLGPLGFASTGDSV-------LPGNIGLWDQIWALKWVKANAEVFGGDPSNILLMGHGTGA 222

  Fly   280 SSVNAQLMSPVTRGLVKRGMMQSGT-----------MNAPWSHMTSEKAVEIGKALIND-CNCNA 332
            :|.:...:||...||.::.::.||:           :||.|:              :|| ..|.|
 Worm   223 ASASLLALSPRAEGLFQKVLLMSGSALQPGVVRNTQVNATWN--------------MNDRFGCRA 273

  Fly   333 SMLKTNPAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTID--GAFLPADPMTLMKTADLKDY 395
                .|.:.::.|.|....:.|...:...:.....|  .|.||  |..||..|..|  |...:..
 Worm   274 ----FNSSELLDCARKRSKEEIFQYKRLHFDDYEEF--VPIIDGVGGILPEPPEQL--TLHRRKT 330

  Fly   396 DILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGN 460
            .|::|..:||.:..:|              |..:|.|.     |...|....|.:....|.  |.
 Worm   331 PIVIGTTKDESSLRIL--------------LLNEKDLN-----FSSITWENGETLADNLTL--GF 374

  Fly   461 PGYQNQQQIGRA-------------------------VGDHF-FTCPTNEYAQALAERGASVHYY 499
            ..:||.:.|.:.                         :..|| :..|.::.|....:....|:.|
 Worm   375 KQFQNHRLISQGCKSEYVWTQVDPSFPESVLFNSLLKMYSHFWYDAPASQLATYYLKHDLPVYLY 439

  Fly   500 YFTHRTSTSLWGEWMGVLHG-DEIEYFFGQP--------LNNSLQYRPVE--RELGKRMLSAVIE 553
            .|.|.:..  :.:.....|| |::..|...|        :|..|..|.||  .||       |..
 Worm   440 SFDHISEN--FYDIDRAFHGVDKLHIFNVTPRFLNKRKDMNWQLDQRVVEIFSEL-------VAN 495

  Fly   554 FAKTGNPAQDGE----EWPNFSKEDPVYYIFSTDDKIEKLA---RGPLAARCSFWNDY 604
            ||..|.|..:.:    .|.:.:.:: :.|:..||....::.   :|.:     |||.|
 Worm   496 FALYGTPTHENDGFSFNWTSTTAKE-LSYLSITDSPSMQVGYRWQGHV-----FWNWY 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_476953.1	COesterase	43..601	CDD:395084	152/627 (24%)
cest-19	NP_509187.4	alpha/beta hydrolases	24..544	CDD:473884	152/629 (24%)