DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and cest-35.1

DIOPT Version :9

Sequence 1:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_504400.1	Gene:	cest-35.1 / 178912	WormBaseID:	WBGene00015067	Length:	545	Species:	Caenorhabditis elegans

Alignment Length:	560	Identity:	147/560 - (26%)
Similarity:	241/560 - (43%)	Gaps:	87/560 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 VVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQER 108
            |:..|.||:||.......:.|..|.|||:||.|:.:|||:|.|.||.|...||..:....|.|.
Worm    16 VLNASCGPIRGNIYEHDDKIVDGYLGIPFAKAPIGELRFKKSVEAEKWTEPLDCYKYGPGCPQS- 79

  Fly   109 YEYFPGFSGEEIWNPNTNVSE----DCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHN 169
                 |..|..|....:.:.|    :||.:||:||.         ....|.|
Worm    80 -----GALGAMIVPQASAIREFAEDNCLTLNVFAPK---------WKSAEFP------------- 117

  Fly   170 GNPQNTTNGLPILIWIYGGGFMTG-SATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMP 233
                   ||||::::.|||||..| |:..|.|:......:.:||:.:..||:|..||.....::
Worm   118 -------NGLPVIVYFYGGGFEVGFSSMFDDYSLTGTLPLKDVILVTPNYRIGPLGFFATGDDV- 174

  Fly   234 SEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRG 298
                  :.||.||||||||::|::.:..:|||:|..:|:.|.|||.:||:...:||.......:.
Worm   175 ------SRGNWGLWDQALALQWVQKHIKSFGGDPSNVTISGTSAGGASVDFLSLSPHANKYFHKF 233

  Fly   299 MMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRSVDAKTISVQQWNSY- 362
            :..||....|:    ..::.::...:..:...:......:...::...:|.||:.....:...|
Worm   234 IPMSGAATCPF----GIRSKDVEGLIFREFAKHHGYAGNDSESLLHWYQSQDAEIFLKAEGFKYP 294

  Fly   363 -SGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLLYDFIDYF--DKDDAT 424
             ||:.||  .|..||.|.|.....|.|.|...|..:.:......|       |.:::  .|....
Worm   295 ASGMFSF--VPNYDGDFFPKPFDELRKEAPKLDAIVSVAEYEGLG-------FEEFYPGQKSPQE 350

  Fly   425 ALPRDKYLEIMNN---IFGKATQAEREAIIFQYTSWEGNPGYQNQQQIGRAVGDHFFTCPTNEYA 486
            .|......|::.|   :..||.:|..|.|       |...|.:..:::....||::|:....:..
Worm   351 VLTAALGPEVVRNREEVVKKAVEAYLENI-------EDKSGEKIGKKLVEIFGDYYFSVGVFDTV 408

  Fly   487 QALAERGASVH---YYYFTHRTSTSLWGE---WMGVLHGDEIEYFFGQPLNNSLQYRPVERELGK 545
            ::||:.|.:|:   :.||...|.. ::||   :....||.:|.|..|..:.   ::...:|::..
Worm   409 RSLAKYGNNVYLSSFNYFNPETPI-MFGENRPFNAASHGCDIRYILGDGIG---EFSKEDRKVMD 469

  Fly   546 RMLSAVIEFAKTGNPAQDGEE--WPNFSKEDPVYYIFSTD 583
            .|.:.:..|||.|||...|..  |..:|.::|..| |..|
Worm   470 MMGTYLTNFAKYGNPNGKGVSIPWEKYSLDNPGRY-FKID 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	147/560 (26%)
cest-35.1	NP_504400.1	COesterase	14..516	CDD:278561	147/560 (26%)
cest-35.1	NP_504400.1	Aes	<106..>214	CDD:223730	44/143 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810