Protein Alignment Ace and cest-10

DIOPT Version :10

• Sequence 1: NP_476953.1
• Gene: Ace / 41625
• FlyBaseID: FBgn0000024
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_501133.3
• Gene: cest-10 / 177493
• WormBaseID: WBGene00016595
• Length: 579
• Species: Caenorhabditis elegans
• Alignment Length: 628
• Identity: 132/628 - (21%)
• Similarity: 221/628 - (35%)
• Gaps: 222/628 - (35%)

  Fly    23 LPLVLVLSLHLSGVCGVIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVP 87
            ||.:.:|.| .|..| .:|.::|:||.|.:.|..:    ...|::..||:||||:..|||:||.|
 Worm     4 LPGIQILFL-FSFSC-FVDSVIVETSLGKLNGDQI----GNFHLFKKIPFAKPPLGKLRFQKPQP 62

  Fly    88 AEPWHGVLDATRLSATCVQERYEYFPGFSGEEIWNPNTN------VSEDCLYINVWAPAKARLRH 146
            ||.|:||.:|......|:.               |.:|.      |.||||::|::. ::..|:
 Worm    63 AETWNGVRNAKDYGPACMS---------------NSSTTKTVQKWVDEDCLHLNIFT-SETCLK- 110

  Fly   147 GRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMA---AV 208
                                         :....::|:::||.....||.:  :|...:.   |.
 Worm   111 -----------------------------SKNCAVVIYLHGGNLHYDSAVM--FNDTFLLHTYAS 144

  Fly   209 GNVIVASFQYRVGAFGFLHLAPEMPSEFAEE----APGNVGLWDQALAIRWLKDNAHAFGGNPEW 269
            ..::......|:|.|          |.|..|    ||.|:.|:|...|:.:.|.:.|.||||.:.
 Worm   145 QEIVFVIPAVRLGIF----------SHFVVEDQSIAPNNLALFDMLQAMEFAKSDIHNFGGNNKR 199

  Fly   270 MTLFGESAG---------SSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALI 325
            .||.|.|.|         |:.||..|..          ..|..:|::|.:..|.|..||......
 Worm   200 TTLLGHSYGGTVASMLSFSTKVNTDLSL----------FQQYISMSSPTNFDTLELQVERTYRFA 254

  Fly   326 NDCNC---NASMLKTN--PAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMT 385
            ...||   |:..::.|  ..::..|::...|..:                             :.
 Worm   255 EHANCLPKNSKFMRKNQKEVYMRDCLKKKSASEL-----------------------------LR 290

  Fly   386 LMKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAI 450
            :.::.:...|.:..|:|. .|..|             ...|.|| :::..|||.......:.|::
 Worm   291 IQRSLEEAGYPVYGGSVM-RGPIF-------------QEVLERD-FMDSPNNITSLTGCTKYESL 340

  Fly   451 IFQYTSWEGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERG---------------------- 493
            ::.:        |:|   :|:|:|...:. ..||..::.::.|
 Worm   341 VYDH--------YRN---MGKALGFENYE-EVNEKYRSDSKEGKIEFDNVKNATQIMLIQIRTRV 393

  Fly   494 --------ASVHYYYFTHRTSTSLWGEWMGVLHGDEIEYFFG-----QPLNNSLQYRPVERELGK 545
                    .:.||.|...:.:.          |.|::.:..|     |..|        |.:||.
 Worm   394 NKILKKNIPAYHYEYAYPKHAN----------HTDDLFFIMGVHPFIQDEN--------EIKLGN 440

  Fly   546 RMLSAVIEFAKTGNPAQ--DGE----------EWPNFSKEDPV 576
            ...|..:.|.|||||..  ||.          .|...:.|.||
 Worm   441 FYRSMFLNFIKTGNPGNGCDGANLNGSTYFEVNWNETTGERPV 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_476953.1	COesterase	43..601	CDD:395084	125/608 (21%)
cest-10	NP_501133.3	alpha/beta hydrolases	20..503	CDD:473884	126/610 (21%)