Protein Alignment Ace and cest-5.1

DIOPT Version :10

• Sequence 1: NP_476953.1
• Gene: Ace / 41625
• FlyBaseID: FBgn0000024
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_501022.3
• Gene: cest-5.1 / 177429
• WormBaseID: WBGene00015279
• Length: 580
• Species: Caenorhabditis elegans
• Alignment Length: 688
• Identity: 146/688 - (21%)
• Similarity: 243/688 - (35%)
• Gaps: 207/688 - (30%)

  Fly    36 VCGVIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRL 100
            :....|.|::.||.|.:.|..:    .:.|::..||:|||||.:|||:||..|..|.|:..|...
 Worm    12 IINAADSLIIHTSFGHLEGAEI----GDYHLFKKIPFAKPPVGNLRFQKPEAAGKWDGIRSAIEY 72

  Fly   101 SATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDH 165
            ...|:.         :..:..:|...|.||||::|::...|..
 Worm    73 GPACMS---------NSSKTKSPQKWVDEDCLHVNIFTSKKCL---------------------- 106

  Fly   166 LIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMA---AVGNVIVASFQYRVGAFGFLH 227
                     .:....|.::|:|||....||.:  :|..::.   ...:||:....:|:|.|
 Worm   107 ---------KSRNCAIAVYIHGGGLTYDSAVM--FNDTVLLDTFVKRDVILVIPGFRLGIF---- 156

  Fly   228 LAPEMPSEFA----EEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAG---------S 279
                  |.|.    ..||.|:.|:|..||:.::|...|:||||.:.:||||.|.|         |
 Worm   157 ------SHFTVHNQNVAPNNLALYDITLALEFVKSEIHSFGGNSQKITLFGHSYGGGLASMMTFS 215

  Fly   280 SSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASM-------LKT 337
            |.:|..|      .|.::.::.||    .:.....:..:|..|..:...||:..:       ...
 Worm   216 SEINRDL------SLFQQAIVMSG----GFYFEELKDHIEGTKRFVEYANCSVPLKLERKMERSQ 270

  Fly   338 NPAHVMSCMRSVDA-KTISVQQWNSYSGILSFPSAPTIDGAFL--PADPMTLMKTADLKDYDILM 399
            ...::|.|::.:.. :.:.:|:      :|.....|...|..|  |..|       |:|.:::|.
 Worm   271 QEMYMMKCLQKLSGMELLRIQR------LLEDKGYPDFGGVILREPLFP-------DVKKFELLK 322

  Fly   400 G--NV-RDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGNP 461
            .  |: ...|...|.:|       .::..:|..||||..|                   ..|.:.
 Worm   323 SPKNIPMLTGCTNLEFD-------HESIKVPFGKYLEFEN-------------------PDECDE 361

  Fly   462 GYQNQQQIG-RAVGDHF-----FTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLHGD 520
            .|:|..:.| ...|:|.     ...|.......|.|...:.:.|.:|:.....         |.|
 Worm   362 KYRNDVESGVENRGNHTDKTQGIILPLKLQINNLLENNVTAYLYEYTYPKHGR---------HTD 417

  Fly   521 EIEYFFG----QPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDGEE------------WPN 569
            ::.|..|    :...|.:....|.:::       ||.|.|.|.|....|:            |..
 Worm   418 DLSYIMGVHAFEKDENEVHLEQVYKDM-------VINFIKLGEPGMGFEKSEQNESTYFDIYWNE 475

  Fly   570 -----------FSKEDPVYYI---FSTDDKIEK---------LARGPLAARCSFWNDYLPKVRSW 611
                       |.||...|::   ...|.|:.:         |...|...:....||.
 Worm   476 TTGERPRMRKYFEKEVTDYWLKEMIEFDQKVTETKKKLKQISLKTVPFIEKPLEQNDE------- 533

  Fly   612 AGTCDGDSGSASISPRLQLLGIAALIYICAALRTKRVF 649
            |||..|.|   .|:..:.|:|.....|.|  ||.:.::
 Worm   534 AGTLIGVS---LIAISIFLIGCIFGRYCC--LRRRNLY 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_476953.1	COesterase	43..601	CDD:395084	131/631 (21%)
cest-5.1	NP_501022.3	alpha/beta hydrolases	17..495	CDD:473884	127/598 (21%)