DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and ace-3

DIOPT Version :9

Sequence 1:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_496963.1	Gene:	ace-3 / 175076	WormBaseID:	WBGene00000037	Length:	607	Species:	Caenorhabditis elegans

Alignment Length:	591	Identity:	190/591 - (32%)
Similarity:	299/591 - (50%)	Gaps:	90/591 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQERY 109
            |||..|.|||.......:.|..:.|:|:|:||:.:.||:||.||.||:|.:.|..||..|.|.|.
Worm    34 VQTKLGTVRGTESDHGNKRVRSFLGVPFAEPPINEHRFKKPTPARPWNGTISANTLSPACFQGRD 98

  Fly   110 EYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQN 174
            .|.|.|.|.|:||.||.|||||||:|:||||.|                         :|
Worm    99 SYDPTFWGSEMWNANTPVSEDCLYVNIWAPADA-------------------------YN----- 133

  Fly   175 TTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEE 239
                |.:|:|::||||..||.:|.:|:...:|..|||||.:..||||.||:|.|.       .|:
Worm   134 ----LTVLVWLFGGGFWYGSPSLLLYDGKELATRGNVIVVNINYRVGPFGYLFLD-------HED 187

  Fly   240 APGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGT 304
            .|||:|:.||.||:.|::|:..:|||||..::|.|||||::|:.|.|::|.::||.:.|::|||:
Worm   188 VPGNMGMLDQQLALYWIRDHIFSFGGNPARISLVGESAGAASIVAHLIAPASKGLFQNGILQSGS 252

  Fly   305 MNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRSVDAKTISVQQWNSYSGILSFP 369
            ::..||..:.::|.:...||.:...||.:.:....|    |:|:..|:.:....||.....|.||
Worm   253 LDNKWSMDSPKRAKQKSTALADLVGCNQTKITDQTA----CLRNTPAQLLIDNIWNVGLNFLEFP 313

  Fly   370 SA---------PTIDGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDA-T 424
            .|         ..:||.      :.|.:.....|.:::.|...|||.::.:|:...:|||... .
Worm   314 FAIVSKDQNFFKHLDGF------IALREGTYSTDVNLMFGINHDEGNFWNIYNLAKFFDKQSVKP 372

  Fly   425 ALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWE-GNPGYQNQ---QQIGRAVGDHFFTCPTNEY 485
            .|.||::.|.::..|....:..|.|..:.|:..: .:|..:..   :|:.:.|||:||||.:..:
Worm   373 GLDRDEFHECVDTAFAVQPELVRTAAKYVYSDPKCTDPKKKTDFYTEQVNQMVGDYFFTCDSIWF 437

  Fly   486 AQ---ALAERGASVHYYYFTHRTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQ-YRPVERELGKR 546
            |.   .:|...::|..|||...:|.:.|.:|.||:||.||||.||.||:|:.. |...|.::.::
Worm   438 AHNYPKMAGNQSNVFVYYFDQPSSANPWPKWTGVMHGYEIEYVFGVPLHNTTAGYTKEEMDVSEK 502

  Fly   547 MLSAVIEFAKTGNPA--------QDGEEWPNFSKEDPVYYI------FSTDDKIEKLARGPLAAR 597
            ::.....||.||.|:        ....:|..:...|...::      |....:|:|:       .
Worm   503 VIDFWTTFANTGVPSLRKRAVGTTQKIKWDRYDGTDHTTWMNIKTGSFRMIQEIKKV-------E 560

  Fly   598 CSFWND 603
            |..|.:
Worm   561 CDLWRN 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	189/587 (32%)
ace-3	NP_496963.1	COesterase	28..564	CDD:278561	189/587 (32%)
ace-3	NP_496963.1	Aes	<123..>234	CDD:223730	56/151 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4389
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45275
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR43918
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.880