DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and cest-27

DIOPT Version :9

Sequence 1:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_871861.2	Gene:	cest-27 / 171610	WormBaseID:	WBGene00018958	Length:	561	Species:	Caenorhabditis elegans

Alignment Length:	612	Identity:	150/612 - (24%)
Similarity:	244/612 - (39%)	Gaps:	130/612 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 VVQTSSGPVRGRSVTVQ-GREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQE 107
            |...:.||::|.....: |..|..:.|||||:||:..|||:|||....|...||..|......|
Worm    27 VHDATCGPIKGVGYEQEDGSVVEGFLGIPYAEPPIGALRFKKPVAHRKWTEPLDCVRFGPRSPQ- 90

  Fly   108 RYEYFPGFSGEEIWNPNTNV----SEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIH 168
                     .:|:.....|.    .|.||.:||:.|.         ....|.|
Worm    91 ---------NDELLGQFVNTVGKSEEHCLSLNVFTPK---------WESNEWP------------ 125

  Fly   169 NGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMA---AVGNVIVASFQYRVGAFGFLHLAP 230
                    :|.|::::|:||||...|::  .|....:|   ...:|:|.:..||:|..||.....
Worm   126 --------DGFPVMVFIHGGGFAVHSSS--NYGCASIARNLCTKDVVVVTINYRLGVLGFFTTGD 180

  Fly   231 EMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLV 295
            |:       ..||:|||||..|:.|:::|..:|.|:|:.:|:||:|||.:||:...:||.:|||.
Worm   181 EV-------CRGNLGLWDQTAALEWVQENIQSFRGDPDNVTIFGQSAGGASVDLLCLSPHSRGLF 238

  Fly   296 KRGMMQSGTMNAPWSHMTSEKAVEIGKALI------NDCNCNASMLK-------------TNPAH 341
            .|.:..:|.....::..|||:..::.:...      .|.|.:..:|:             .||..
Worm   239 NRAIPMAGNGECDFAMRTSEQQAQLSREFARYLGWEGDDNDSEDLLQFIDQQPLYKIEMGINPKR 303

  Fly   342 VMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNVRDEG 406
            ...               :|.:|.|.|  .|..||.|.|.....|.|.|  ....|:.|..:.||
Worm   304 GFK---------------HSQAGSLYF--VPNFDGDFFPKPLNQLRKEA--PKMQIMTGTTKYEG 349

  Fly   407 TYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAII------FQYTSWEGNPGYQN 465
            .:|:..         .|.:...:...:.|..||.:....||...:      |.:.........:|
Worm   350 LFFIAL---------GALSKNPEGIKKFMGRIFKECDYGERADDVLQMVYDFYFKGVHPKDHEKN 405

  Fly   466 QQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWG--EW----MGVLHGDEIEY 524
            ..||.:.:||:.....|...|..:.:....|::|.|.:..|.. :|  .|    :|..|..|:.|
Worm   406 MHQIVKFIGDYSINYGTYRLANIMTDLQHDVYFYQFDYHNSAG-FGVFRWLLPFLGSTHCTEMRY 469

  Fly   525 FFGQPLNNSLQYRPVERELGKRMLSAV----IEFAKTGNPAQDGEEWPNFSKEDPVYYI--FSTD 583
            ..|:.:.:  ::||.:.:  |:||..:    ..|||.|||..:.:|...:.|.|..:..  |..|
Worm   470 VLGKGIIS--KFRPNDND--KKMLHVMTTYFTNFAKYGNPNGENQETGEWQKHDSAHPFRHFKID 530

  Fly   584 DKIEKLARGPLAARCSFWNDYLPKVRS 610
            ....::.......|...|:    |:|:
Worm   531 LDDSEMVEDYQERRAELWD----KLRA 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	147/601 (24%)
cest-27	NP_871861.2	COesterase	29..541	CDD:278561	145/592 (24%)
cest-27	NP_871861.2	Aes	<114..>283	CDD:223730	55/206 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810