Protein Alignment Ace and Ces1c

DIOPT Version :9

• Sequence 1: NP_001163600.1
• Gene: Ace / 41625
• FlyBaseID: FBgn0000024
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_031980.2
• Gene: Ces1c / 13884
• MGIID: 95420
• Length: 554
• Species: Mus musculus
• Alignment Length: 614
• Identity: 177/614 - (28%)
• Similarity: 281/614 - (45%)
• Gaps: 128/614 - (20%)

  Fly    36 VCGVIDRL----VVQTSSGPVRGRSVTVQGRE--VHVYTGIPYAKPPVEDLRFRKPVPAEPWHGV 94
            ||.::...    ||.|:.|.|.|:.::::|.|  |.|:.|:|:||||:..|||..|.|||||..|
Mouse    13 VCPILGHSLLPPVVDTTQGKVLGKYISLEGFEQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFV 77

  Fly    95 LDATRLSATCVQERYEYFPG--------FSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGAN 151
            .:||.....|.|:     .|        ||.|:...| ..:||||||:|:::||..
Mouse    78 KNATSYPPMCSQD-----AGWAKILSDMFSTEKEILP-LKISEDCLYLNIYSPADL--------- 127

  Fly   152 GGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASF 216
                                  ..::.||:::||:|||.:.|.|:  .||...::|..||:|.:.
Mouse   128 ----------------------TKSSQLPVMVWIHGGGLVIGGAS--PYNGLALSAHENVVVVTI 168

  Fly   217 QYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSS 281
            |||:|.:|..       |...|.:|||....||..|:||::||...|||||:.:|:||||:|..|
Mouse   169 QYRLGIWGLF-------STGDEHSPGNWAHLDQLAALRWVQDNIANFGGNPDSVTIFGESSGGIS 226

  Fly   282 VNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCM 346
            |:..::||:.:.|..|.:.:||.:........:.:||....|.::.||      .|:.|.::.|:
Mouse   227 VSVLVLSPLGKDLFHRAISESGVVINTNVGKKNIQAVNEIIATLSQCN------DTSSAAMVQCL 285

  Fly   347 RSVDAKTISVQQWNSYSGIL---SFPSAPTIDGAFLPADPMTLMKTADLKDYDILMG-------- 400
            |.   ||.|  :....||.|   :...:..|||..||..|..::..........::|
Mouse   286 RQ---KTES--ELLEISGKLVQYNISLSTMIDGVVLPKAPEEILAEKSFNTVPYIVGFNKQEFGW 345

  Fly   401 -------NVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWE 458
                   |:..||.          .:::.|:.|.|..:.|:  ||    :::...|:|.||....
Mouse   346 IIPMMLQNLLPEGK----------MNEETASLLLRRFHSEL--NI----SESMIPAVIEQYLRGV 394

  Fly   459 GNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTS-------TSLWGEWMGV 516
            .:|. :..:.|....||.||..|....:::|.:.|.|.:.|.|.:|.|       .::.|:
Mouse   395 DDPA-KKSELILDMFGDIFFGIPAVLLSRSLRDAGVSTYMYEFRYRPSFVSDKRPQTVEGD---- 454

  Fly   517 LHGDEIEYFFGQPLNNSLQYRPVERE--LGKRMLSAVIEFAKTGNPAQDG-EEWPNFSKEDPVYY 578
             |||||.:.||.||   |:....|.|  |.|.::.....||:.|||..:| ..||.:.:::....
Mouse   455 -HGDEIFFVFGAPL---LKEGASEEETNLSKMVMKFWANFARNGNPNGEGLPHWPEYDEQEGYLQ 515

  Fly   579 IFSTDDKIEKLARGPLAARCSFWNDYLPK 607
            |.:|..:.::|.    |...:||.:.|.|
Mouse   516 IGATTQQAQRLK----AEEVAFWTELLAK 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	171/601 (28%)
Ces1c	NP_031980.2	Esterase_lipase	25..525	CDD:238191	169/581 (29%)
		Aes	<121..>234	CDD:223730	47/152 (31%)
		Prevents secretion from ER. /evidence=ECO:0000255	551..554

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810