DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and Ces1g

DIOPT Version :9

Sequence 1:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_067431.2	Gene:	Ces1g / 12623	MGIID:	88378	Length:	565	Species:	Mus musculus

Alignment Length:	618	Identity:	163/618 - (26%)
Similarity:	250/618 - (40%)	Gaps:	145/618 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 VVQTSSGPVRGRSVTVQG--REVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQ 106
            ||.|..|.|.|:.||::|  :.|.|:.|:|:||||:..|||..|.|||||..|...|.....|.|
Mouse    25 VVHTVHGKVLGKYVTLEGFSQPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKHTTSYPPLCYQ 89

  Fly   107 ERYEYFPGFSGEEIWNPN---------TN--------VSEDCLYINVWAPAKARLRHGRGANGGE 154
                           ||.         ||        .||||||:|::.||..
Mouse    90 ---------------NPEAALRLAELFTNQRKIIPHKFSEDCLYLNIYTPADL------------ 127

  Fly   155 HPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYR 219
                             .||:.  ||:::||:|||.:...|:  .|:...:|...||:|...|||
Mouse   128 -----------------TQNSR--LPVMVWIHGGGLVIDGAS--TYDGVPLAVHENVVVVVIQYR 171

  Fly   220 VGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNA 284
            :|.:||.       |...|.:.||.|..||..|:.|::||...|||||..:|:||||||..||:.
Mouse   172 LGIWGFF-------STEDEHSRGNWGHLDQVAALHWVQDNIANFGGNPGSVTIFGESAGGESVSV 229

  Fly   285 QLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMR-S 348
            .::||:.:.|..|.:.||..:..|.  :....|..:.|.:.....|..    |..|.::.|:| .
Mouse   230 LVLSPLAKNLFHRAIAQSSVIFNPC--LFGRAARPLAKKIAALAGCKT----TTSAAMVHCLRQK 288

  Fly   349 VDAKTISVQQWNSYSGI-------LSFPSAPT-IDGAFLPADPMTLMKTADLKDYDILMG-NVRD 404
            .:.:.:.|.....:..:       .|:|..|| |||..||..|..::..........::| |..:
Mouse   289 TEDELLEVSLKMKFGTVDFLGDPRESYPFLPTVIDGVLLPKAPEEILAEKSFNTVPYMVGINKHE 353

  Fly   405 EGTYFLLYDFIDY------FDKDDATALPRDKY--LEIMNNIFGKATQAEREAIIFQYTSWEGNP 461
            .|  :::..|:|:      .|:..|.::....|  |.|...:.        .|.|.:|.....:|
Mouse   354 FG--WIIPMFLDFPLSERKLDQKTAASILWQAYPILNISEKLI--------PAAIEKYLGGTEDP 408

  Fly   462 GYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTS-------TSLWGEWMGVLHG 519
            .......:. .:||..|..|:...:::..:.||..:.|.:.:|.|       ..|.|:     |.
Mouse   409 ATMTDLFLD-LIGDIMFGVPSVIVSRSHRDAGAPTYMYEYQYRPSFVSDDRPQELLGD-----HA 467

  Fly   520 DEIEYFFGQPLNNSLQYRPVERE--LGKRMLSAVIEFAKTGNPAQDG-EEWPNFSKED------- 574
            ||:...:|.|.   |:....|.|  |.|.::.....||:.|||..:| ..||.:.:::
Mouse   468 DELFSVWGAPF---LKEGASEEEINLSKMVMKFWANFARNGNPNGEGLPHWPEYDQKEGYLQIGV 529

  Fly   575 PVYYIFSTDDKIEKLARGPLAARCSFWNDYLPK 607
            |........||           ...||.:...|
Mouse   530 PAQAAHRLKDK-----------EVDFWTELRAK 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	160/610 (26%)
Ces1g	NP_067431.2	COesterase	24..545	CDD:278561	160/610 (26%)
Ces1g	NP_067431.2	Aes	<121..>239	CDD:223730	50/157 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810