Protein Alignment Ace and ache

DIOPT Version :10

• Sequence 1: NP_476953.1
• Gene: Ace / 41625
• FlyBaseID: FBgn0000024
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_571921.1
• Gene: ache / 114549
• ZFINID: ZDB-GENE-010906-1
• Length: 634
• Species: Danio rerio
• Alignment Length: 646
• Identity: 225/646 - (34%)
• Similarity: 327/646 - (50%)
• Gaps: 107/646 - (16%)

  Fly    23 LPLVLVLSLHLSGVCGVIDRLVVQTSSGPVRGRSVTVQGREVHV--YTGIPYAKPPVEDLRFRKP 85
            ||.||:..|..:........|||.|..|.|:|..:.|..|. ||  :.|||||:||:...||::.
Zfish     9 LPTVLLTFLFHNCFAQAEPDLVVATRLGRVQGTRLPVPDRS-HVIAFLGIPYAEPPIGKRRFKRA 72

  Fly    86 VPAEPWHGVLDATRLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGA 150
            .|.:||:.|.:|...|..|.|.....:|||.|.|:||||..:||||||:|||.|...|
Zfish    73 EPKKPWNNVFEAKEFSNACYQFVDTSYPGFPGIEMWNPNRVMSEDCLYLNVWVPPTPR------- 130

  Fly   151 NGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVAS 215
                                 |||.|    :::|||||||.:||::||:|:...:|....|:|.|
Zfish   131 ---------------------PQNLT----VMVWIYGGGFYSGSSSLDVYDGRYLAYTEKVVVVS 170

  Fly   216 FQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSS 280
            ..|||||||||.|      ..:.:|||||||:||.||::|:::|.|.|||||:.:|:||||||::
Zfish   171 MNYRVGAFGFLAL------NGSSDAPGNVGLYDQRLALQWVQENIHFFGGNPKQVTIFGESAGAA 229

  Fly   281 SVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKA----VEIGKALINDCNCNASMLKTNPAH 341
            ||...::||.:|.|..|.::|||..|.||:.:|.::|    .::||.:    .|...    |...
Zfish   230 SVGMHVLSPDSRPLFTRAILQSGVPNTPWATVTFDEARRRTTKLGKLV----GCTWG----NDTE 286

  Fly   342 VMSCMRSVDAKTISVQQWN--SYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNVRD 404
            ::.|:|:...:.:..|:|.  .:|.:..|...|.:||.|.|..|..::.:.:.|...||:|..:|
Zfish   287 LIDCLRNKHPQELIDQEWQVLPWSSLFRFSFVPVVDGVFFPDTPDAMISSGNFKYTQILLGVNQD 351

  Fly   405 EGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSW-EGNPGYQNQQQ 468
            ||:|||||. ...|.||:.:.:.|:.:||.:......|.....||:|.|||.| :.|.|.:|:..
Zfish   352 EGSYFLLYG-APGFSKDNESLISREDFLESVKMGVPHANDIGLEAVILQYTDWMDENNGQKNRDA 415

  Fly   469 IGRAVGDHFFTCPTNEYAQALAERGA------------------------------SVHYYYFTH 503
            :...|||....||...:|::.|:..|                              :|:.|.|.|
Zfish   416 MDDIVGDQNVICPLQHFAKSYAQYAALHAQSSAAAPGTLGWGNSGPTGYNSGNSHGAVYLYLFDH 480

  Fly   504 RTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNP--AQDG-- 564
            |.|...|.|||||:||.|||:.||.||...|.|...|.:|.:|::.....||:||||  ..||
Zfish   481 RASNLAWPEWMGVIHGYEIEFVFGLPLEKRLNYTAEEEKLSRRIMRYWANFARTGNPNVNTDGTM 545

  Fly   565 ---EEWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKV-----------RSW 611
               ..||.||..:..:...:|:..  |:.:|.....|:.||.:||::           |.|
Zfish   546 DSRRRWPQFSANEQKHVGLNTEPM--KVHKGLRTQFCALWNRFLPRLLNITDNIDDVERQW 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_476953.1	COesterase	43..601	CDD:395084	214/603 (35%)
ache	NP_571921.1	COesterase	27..583	CDD:395084	214/605 (35%)
		AChE_tetra	598..631	CDD:430146	2/7 (29%)