DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and Ces1d

DIOPT Version :9

Sequence 1:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_579829.3	Gene:	Ces1d / 113902	RGDID:	70896	Length:	565	Species:	Rattus norvegicus

Alignment Length:	611	Identity:	169/611 - (27%)
Similarity:	262/611 - (42%)	Gaps:	131/611 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 VVQTSSGPVRGRSVTVQG--REVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQ 106
            ||.|..|.|.|:.|.::|  :.|.|:.|||:||||:..|||..|.|||||:.|.:.|.....|.|
  Rat    25 VVNTVKGKVLGKYVNLEGFAQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWNFVKNTTSYPPMCSQ 89

  Fly   107 ERYEYFPGFSGEEIWNPNTN--------VSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADT 163
            :      ...|:.:....||        .||||||:||:.||..
  Rat    90 D------AVGGQVLSELFTNRKENIPLQFSEDCLYLNVYTPADL--------------------- 127

  Fly   164 DHLIHNGNPQNTTNG-LPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLH 227
                       |.|. ||:::||:|||.:.|.|:  .|:..:::|..||:|.:.|||:|.:||.
  Rat   128 -----------TKNSRLPVMVWIHGGGLVVGGAS--TYDGQVLSAHENVVVVTIQYRLGIWGFF- 178

  Fly   228 LAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTR 292
                  |...|.:.||.|..||..|:.|::||...|||||..:|:||||||..||:|.::||:.:
  Rat   179 ------STGDEHSQGNWGHLDQVAALHWVQDNIANFGGNPGSVTIFGESAGGFSVSALVLSPLAK 237

  Fly   293 GLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVM-SCMR--SVDAKTI 354
            .|..|.:.:||.:.......|..|.:....|.::.|       ||..:.|| .|:|  :.|....
  Rat   238 NLFHRAISESGVVLTSALITTDSKPIANLIATLSGC-------KTTTSAVMVHCLRQKTEDELLE 295

  Fly   355 SVQQWNSYSGIL------SFPSAPT-IDGAFLPADPMTLMKTADLKDYDILMG-NVRDEGTYFLL 411
            :..:.|.:...|      |:|..|| |||..||..|..::..........::| |.::.|  :::
  Rat   296 TSLKLNLFKLDLLGNPKESYPFLPTVIDGVVLPKTPEEILTEKSFNTVPYIVGINKQEFG--WII 358

  Fly   412 YDFIDY------FDKDDATAL-----PRDKYLE-----IMNNIFGKATQAEREAIIFQYTSWEGN 460
            ...:.|      .|:..|.:|     |..|..|     :....||......:...:||
  Rat   359 PTLMGYPLSEGKLDQKTAKSLLWKSYPTLKISEKMIPVVAEKYFGGTDDPAKRKDLFQ------- 416

  Fly   461 PGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTS-------TSLWGEWMGVLH 518
                      ..|.|..|..|:...:::..:.||....|.|.:|.|       .::.|:     |
  Rat   417 ----------DLVADVMFGVPSVMVSRSHRDAGAPTFMYEFEYRPSFVSAMRPKTVIGD-----H 466

  Fly   519 GDEIEYFFGQP-LNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDG-EEWPNFSKEDPVYYIFS 581
            |||:...||.| |.:.....  |..|.|.::.....||:.|:|...| ..||.:.:::....|.:
  Rat   467 GDELFSVFGSPFLKDGASEE--ETNLSKMVMKYWANFARNGSPNGGGLPHWPEYDQKEGYLKIGA 529

  Fly   582 TDDKIEKLARGPLAARCSFWNDYLPK 607
            :....::|....:|    ||::...|
  Rat   530 STQAAQRLKDKEVA----FWSELRAK 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	166/603 (28%)
Ces1d	NP_579829.3	COesterase	24..545	CDD:278561	166/603 (28%)
		Aes	<121..>239	CDD:223730	53/158 (34%)
		Prevents secretion from ER. /evidence=ECO:0000255	562..565
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810