Protein Alignment Ace and CES1

DIOPT Version :9

• Sequence 1: NP_001163600.1
• Gene: Ace / 41625
• FlyBaseID: FBgn0000024
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001020366.1
• Gene: CES1 / 1066
• HGNCID: 1863
• Length: 568
• Species: Homo sapiens
• Alignment Length: 615
• Identity: 169/615 - (27%)
• Similarity: 261/615 - (42%)
• Gaps: 137/615 - (22%)

  Fly    44 VVQTSSGPVRGRSVTVQG--REVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQ 106
            ||.|..|.|.|:.|:::|  :.|.::.|||:||||:..|||..|.|||||..|.:||.....|.|
Human    26 VVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQ 90

  Fly   107 E-------------RYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNG 158
            :             |.|..|           ..:||||||:|::.||....:
Human    91 DPKAGQLLSELFTNRKENIP-----------LKLSEDCLYLNIYTPADLTKK------------- 131

  Fly   159 KQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAF 223
                              |.||:::||:|||.|.|:|:  .|:...:||..||:|.:.|||:|.:
Human   132 ------------------NRLPVMVWIHGGGLMVGAAS--TYDGLALAAHENVVVVTIQYRLGIW 176

  Fly   224 GFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMS 288
            ||.       |...|.:.||.|..||..|:||::||..:|||||..:|:||||||..||:..::|
Human   177 GFF-------STGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLS 234

  Fly   289 PVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIG--KALINDCNCNASMLKTNPAHVMSCMR---- 347
            |:.:.|..|.:.:||..      :|| ..|:.|  |.|.......|....|..|.::.|:|
Human   235 PLAKNLFHRAISESGVA------LTS-VLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTE 292

  Fly   348 ------SVDAKTISVQQWNSYSGILSFP--SAP----TIDGAFLPADPMTLMKTADLKDYDILMG 400
                  ::..|.:|:.       :...|  |.|    .|||..|...|..|....:......::|
Human   293 EELLETTLKMKFLSLD-------LQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVG 350

  Fly   401 NVRDEGTYFLLYDFIDY------FDKDDATALPRDKY--LEIMNNIFGKATQAEREAIIFQYTSW 457
            ..:.|..:.:....:.|      .|:..|.:|....|  :.|...:..:||:        :|...
Human   351 INKQEFGWLIPMQLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATE--------KYLGG 407

  Fly   458 EGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTS-------LWGEWMG 515
            ..:. .:.:......:.|..|..|:...|:...:.||..:.|.|.:|.|.|       :.|:
Human   408 TDDT-VKKKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGD--- 468

  Fly   516 VLHGDEIEYFFGQPLNNSLQYRPVERE--LGKRMLSAVIEFAKTGNPAQDG-EEWPNFSKEDPVY 577
              ||||:...||.|.   |:....|.|  |.|.::.....||:.|||..:| ..||.:::::...
Human   469 --HGDELFSVFGAPF---LKEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYL 528

  Fly   578 YIFSTDDKIEKLARGPLAARCSFWNDYLPK 607
            .|.:.....:||....:|    ||.:...|
Human   529 QIGANTQAAQKLKDKEVA----FWTNLFAK 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	166/607 (27%)
CES1	NP_001020366.1	COesterase	25..548	CDD:278561	166/607 (27%)
		Aes	<122..>240	CDD:223730	53/157 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810