Protein Alignment Ace and CEL

DIOPT Version :9

• Sequence 1: NP_001163600.1
• Gene: Ace / 41625
• FlyBaseID: FBgn0000024
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001798.3
• Gene: CEL / 1056
• HGNCID: 1848
• Length: 753
• Species: Homo sapiens
• Alignment Length: 612
• Identity: 179/612 - (29%)
• Similarity: 265/612 - (43%)
• Gaps: 94/612 - (15%)

  Fly    45 VQTSSGPVRG--RSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQE 107
            |.|..|.|.|  :.:.:.|..|.::.|||:|.|   ......|.|...|.|.|.|......|:|
Human    26 VYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAP---TKALENPQPHPGWQGTLKAKNFKKRCLQ- 86

  Fly   108 RYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNP 172
                      ..|...:|...|||||:|:|.|      .||          ||...|
Human    87 ----------ATITQDSTYGDEDCLYLNIWVP------QGR----------KQVSRD-------- 117

  Fly   173 QNTTNGLPILIWIYGGGFMTGSA------TLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPE 231
                  ||::||||||.|:.||.      ...:|:.:.:|..|||||.:|.||||..|||
Human   118 ------LPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFL----- 171

  Fly   232 MPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVK 296
              |......|||.||.||.:||.|:|.|..||||:|..:||||||||.:||:.|.:||..:||::
Human   172 --STGDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIR 234

  Fly   297 RGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRSVDAKTISVQQWNS 361
            |.:.|||...:||  :..:..:...|.:.....|...    :.|.:..|::..|.:.:::.....
Human   235 RAISQSGVALSPW--VIQKNPLFWAKKVAEKVGCPVG----DAARMAQCLKVTDPRALTLAYKVP 293

  Fly   362 YSGILSFPS------APTIDGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDK 420
            .:| |.:|.      .|.|||.|:||||:.|.  |:..|.|.:.|....:|..|...| :...:|
Human   294 LAG-LEYPMLHYVGFVPVIDGDFIPADPINLY--ANAADIDYIAGTNNMDGHIFASID-MPAINK 354

  Fly   421 DDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGNPGYQNQQQ-IGRAVGDHFFTCPTNE 484
            .:......|.|..:......|..:..:........||..:|..:|::: :.....|..|..||.
Human   355 GNKKVTEEDFYKLVSEFTITKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTE- 418

  Fly   485 YAQALAE-----RGASVHYYYFTHRTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELG 544
              .|||:     :.|..:.|.|:|.:...::.:|:|..|.|:|:|.||:|......|||.:|.:.
Human   419 --IALAQHRANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVS 481

  Fly   545 KRMLSAVIEFAKTGNPAQDGE----EWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWN-DY 604
            |.|::....|||||:|.....    .|..::.|:..|...:.......:.|........:|. .|
Human   482 KAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLRYWTLTY 546

  Fly   605 --LPKVRSWAGT---CDGDSGSASISP 626
              ||.|.....|   ..|||.:..:.|
Human   547 LALPTVTDQEATPVPPTGDSEATPVPP 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	169/579 (29%)
CEL	NP_001798.3	Heparin-binding	21..121		37/138 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	555..753		5/19 (26%)
		17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type)	559..745		4/15 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810