DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and LOC100334697

DIOPT Version :9

Sequence 1:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_002661384.2	Gene:	LOC100334697 / 100334697	-ID:	-	Length:	576	Species:	Danio rerio

Alignment Length:	605	Identity:	158/605 - (26%)
Similarity:	253/605 - (41%)	Gaps:	127/605 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 QTSSGP-VRGRSVTVQG---REVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQ 106
            :|:.|| :..:...|||   .:.:|:.|||:|.|||...|::.|.|..||.||.||:...|.|:|
Zfish    45 RTADGPKLLIKDGLVQGLLLDKSYVFYGIPFADPPVGTSRWKAPRPVTPWKGVYDASFPRAACMQ 109

  Fly   107 ERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGN 171
                   ...|....:....|||||||:||:.|....|                         ..
Zfish   110 -------ACIGPIADDCPKKVSEDCLYLNVFVPLSVDL-------------------------AT 142

  Fly   172 PQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEF 236
            |  ....||:::||:||.|:.|||:..:|:...::.....::.|..||:||||||....:..|
Zfish   143 P--LLQPLPVMLWIHGGDFIAGSASKPLYDGRFISNYTQTVIVSIAYRLGAFGFLVSGKDPKS-- 203

  Fly   237 AEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQ 301
              .|.||.|:.||..|:.|::.|..||||:|..:|:||||||:.||:..||...::.|.|:.:.|
Zfish   204 --TAVGNYGILDQQAALIWVQQNIAAFGGDPSRVTIFGESAGAQSVSLHLMIQSSKPLFKQAVFQ 266

  Fly   302 SGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRSVDAKTISVQQWNSYSGIL 366
            |...:.|..  |..:::::||......||:...:|        |::|:.|:.:...|..:.|.::
Zfish   267 SLPFSIPLK--TRRESLKLGKHFAKAANCSLEDMK--------CLQSLSAEDVLHAQIKTSSKLV 321

  Fly   367 SFPS---------APTIDGAFLPADPMTLMKTAD-LKDYDILMGNVRDEGTYFLLYDFIDYFDKD 421
            : |.         .|.|||..:....::..:... .|:..:|:|...:||..|:    ...|.|.
Zfish   322 N-PFRFLEVFEIWGPFIDGELIKEQAVSAFQKGHWQKEKPVLLGTTSEEGVIFV----YGVFKKP 381

  Fly   422 DA--------TALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGNPGYQNQQQIGRAVGDHFF 478
            .:        ||:.:...::|:.......:.|:|                  :..:.:.|.|:.|
Zfish   382 VSAVECTIYTTAIFKQHAIKILRKYLPLYSDADR------------------RDMLAQIVTDYIF 428

  Fly   479 TCPTNEYAQALAERGASVHYYYFTHRTS-TSLWGE----WMGVLHGDEIEYFFGQPLNNSLQYRP 538
            .||:...|:|....|:|...|.|...:| ..:|..    :..|.||.|:.:.|......:....|
Zfish   429 WCPSRRSARAAVLSGSSAWMYVFDQVSSDPRVWSGVSSCYQRVCHGAELPFVFDSASVANFSMTP 493

  Fly   539 VERELGKRMLSAVIEFAKTGNPA---------------QDGEEWPNFSKEDPVYYIFSTDDKIEK 588
            .|:.|..|:|.....||.||||.               |....||:        |..:....|..
Zfish   494 AEKLLSNRVLCYWGGFAHTGNPTGETRRPSDISGFCRQQRPPSWPS--------YTANRGWMIMN 550

  Fly   589 LARGPLAAR------CSFWN 602
            |...|.:..      |.||:
Zfish   551 LTAHPHSQAGYGEDICDFWD 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	156/602 (26%)
LOC100334697	XP_002661384.2	COesterase	44..569	CDD:278561	156/602 (26%)
LOC100334697	XP_002661384.2	Aes	<138..>245	CDD:223730	44/137 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910