DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and ces3.1

DIOPT Version :9

Sequence 1:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001120019.1	Gene:	ces3.1 / 100144981	XenbaseID:	XB-GENE-6467140	Length:	557	Species:	Xenopus tropicalis

Alignment Length:	643	Identity:	186/643 - (28%)
Similarity:	282/643 - (43%)	Gaps:	170/643 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VLVLSLHLSGVCGVID-RLVVQTSSGPVRGRSVTVQ--GREVHVYTGIPYAKPPVEDLRFRKPVP 87
            ||:|......:.|..| |.::.|..|.:.|::|..:  .|.|||:.|:|:||||:..|||..|.|
Frog     7 VLLLCCATLEIYGTEDARPLLMTKYGQLLGKTVGAKETDRLVHVFMGVPFAKPPIGPLRFEAPQP 71

  Fly    88 AEPWHGVLDATRLSATCVQER------YEYFPG---FSGEEIWNPNTNVSEDCLYINVWAPAKAR 143
            .|||..|.:||..|..|:|::      .::|..   ||         .|||||||:||:.|
Frog    72 PEPWSSVREATAPSPMCLQDKEVMELLADFFKAKFDFS---------RVSEDCLYLNVFTP---- 123

  Fly   144 LRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAV 208
                  |:.||:|                     |||::::|:|||...|.|::  :....::|.
Frog   124 ------ADKGENP---------------------GLPVMVFIHGGGLAIGGASM--FEGSALSAY 159

  Fly   209 GNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLF 273
            .||:|.|.|||:|..|||       |...:|..||.|..||..|::|::||...|||:|:.:|:|
Frog   160 ENVVVVSIQYRLGIMGFL-------STGDKEVRGNFGFLDQVAALQWVRDNIKDFGGDPQSVTIF 217

  Fly   274 GESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKAL---INDCNCNASML 335
            |||||..||:|.::||::.||..|.:.:||....|  .:|:.|..||...|   ||..:|:.|.|
Frog   218 GESAGGLSVSALVLSPLSEGLFHRAIAESGVAILP--GLTASKTEEILPLLDMVINVSSCSVSDL 280

  Fly   336 KTNPAHVMSCMRS-VDAKTISVQQWNSYSGILSFPSAPTIDGAFLPAD----------------- 382
                   :.|::: .:.:.|.:.....|   :.||:  .:||.|||..
Frog   281 -------VGCLKNKTEDEIIEITAAMRY---VIFPA--VVDGVFLPKPAEEILAAKESHPVPFLI 333

  Fly   383 -----------PMTLMKTA-----DLKDYDILMGNVRDEGTYFLLYDFI--DYF-DKDDATALPR 428
                       |:||..|.     :.||...::|.:....|...:..||  :|| |.:|    |:
Frog   334 GINNHEFGSMLPVTLNITGYREGMEKKDIQAILGALPLLNTVSSVIPFIMEEYFGDTND----PK 394

  Fly   429 DKYLEIMNNIFGKATQAEREAIIFQYTSWEGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERG 493
                |:.||....|                               ||..|..|....|:...:.|
Frog   395 ----ELRNNFLDLA-------------------------------GDIIFVIPALRTAKYHRDSG 424

  Fly   494 ASVHYYYFTHRTSTSLWG----EWMGVLHGDEIEYFFGQP-LNNSLQYR----PVERELGKRMLS 549
            ..|::|.|.||  .||:.    :::...||||:.:..|.| |.|.:.::    ..|:.|.|.::.
Frog   425 FPVYFYEFQHR--PSLYADSKEDFVKADHGDELYFVGGGPFLKNGILFKSNGTEEEKILSKTIMK 487

  Fly   550 AVIEFAKTGNPAQDG-EEWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDYLP 606
            ....||:.|:|...| .|||.:. ||..|...:...|..:..:|   .|..||...||
Frog   488 YWANFARNGDPNGHGLAEWPKYD-EDEDYLEINLTQKSSQRLKG---ERFEFWTITLP 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	178/621 (29%)
ces3.1	NP_001120019.1	COesterase	25..536	CDD:365897	176/618 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910