DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8483 and CRISPLD2

DIOPT Version :9

Sequence 1:	NP_650264.1	Gene:	CG8483 / 41623	FlyBaseID:	FBgn0038126	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_113664.1	Gene:	CRISPLD2 / 83716	HGNCID:	25248	Length:	497	Species:	Homo sapiens

Alignment Length:	278	Identity:	87/278 - (31%)
Similarity:	121/278 - (43%)	Gaps:	72/278 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 IASGITAEERSIILQEHNRLRQIVATGRYPGQPGAENMREIVWDDELAARAQKWADNCQFRHDPH 92
            :...|..|::..||..||:||..|       ||.|.||..:.|||||...|..||..|.:.|.|
Human    47 VRRAIPREDKEEILMLHNKLRGQV-------QPQASNMEYMTWDDELEKSAAAWASQCIWEHGP- 103

  Fly    93 RTINRFTMGQNLAIIWSTAPLDADDGDFPS---RIQSWFNEVQKYSFG-----DAWSPK--TG-- 145
             |....::||||...|         |.:.|   .:|||::||:.|::.     :.|.|:  :|
Human   104 -TSLLVSIGQNLGAHW---------GRYRSPGFHVQSWYDEVKDYTYPYPSECNPWCPERCSGPM 158

  Fly   146 --HYSQLVWGETSLVGCG---------YAEYKDTSKYNKLYVCNYGPGGNVVGYNPYEVGKPSCS 199
              ||:|:||..|:.:||.         :.|..:.:.|   :||||.|.||.:|..||:.|:| ||
Human   159 CTHYTQIVWATTNKIGCAVNTCRKMTVWGEVWENAVY---FVCNYSPKGNWIGEAPYKNGRP-CS 219

  Fly   200 TYGMKPSSRYQGLCAAPGSSPAANSVYGANTIETYEYGYNSSPSSQTAN-NNPPTNNINKSQFSY 263
            .  ..||  |.|.|       ..|..|..   |||      :|..:|.. |...|..|.:....:
Human   220 E--CPPS--YGGSC-------RNNLCYRE---ETY------TPKPETDEMNEVETAPIPEENHVW 264

  Fly   264 NQPR------PKPVQTIN 275
            .|||      ||....:|
Human   265 LQPRVMRPTKPKKTSAVN 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8483	NP_650264.1	SCP_euk	37..180	CDD:240180	53/165 (32%)
CRISPLD2	NP_113664.1	SCP_euk	56..201	CDD:240180	53/165 (32%)
		LCCL	286..370	CDD:128866
		LCCL	387..479	CDD:128866
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151106
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2340
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1528782at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750