DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MCAM and beat-VII

DIOPT Version :9

Sequence 1:	NP_006491.2	Gene:	MCAM / 4162	HGNCID:	6934	Length:	646	Species:	Homo sapiens
Sequence 2:	NP_733162.2	Gene:	beat-VII / 43213	FlyBaseID:	FBgn0250908	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	173	Identity:	44/173 - (25%)
Similarity:	69/173 - (39%)	Gaps:	31/173 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   331 LLSEPQELLVNYVSDVRVSPAAPERQE-GSSLTLTCEAESSQDLEFQ--WLREETGQVLE----R 388
            ||...|...:|..|||.|:...|...| |||.|..|......::.|:  ||:.:.|:..|    |
  Fly    10 LLGLQQTKPINGQSDVLVNLVVPRYVERGSSATFKCTHNVRPEILFKVTWLKVDKGKFFEFINGR 74

Human   389 GPVLQ--------------------LHDLKREAGGGYRCVAS--VPSIPGLNRTQLVNVAI--FG 429
            .|..:                    |.|::.:..|.:.|..|  .|.....:..:|::|.:  .|
  Fly    75 NPPFRNSTIEGAEIDWDNSNEQQVTLKDVQFDLSGQFYCEVSTDTPIFTKASADELMSVFLPQTG 139

Human   430 PPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASE 472
            ||.:.|::|..:.....:..|.....|.|.|.|:|.:||...|
  Fly   140 PPTIKFRKRTPFAVGEKLFALCNTTRGRPAPHITWLINGKKVE 182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MCAM	NP_006491.2	Ig	33..117	CDD:325142
		C2-set_2	139..234	CDD:311910
		Ig_3	261..321	CDD:316449
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..299
		Ig_3	346..410	CDD:316449	20/90 (22%)
		Ig	450..510	CDD:325142	9/23 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..554
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	620..646
beat-VII	NP_733162.2	Ig	31..118	CDD:299845	19/86 (22%)
		IG_like	34..118	CDD:214653	18/83 (22%)
		Ig	141..>183	CDD:299845	12/42 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910