DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MCAM and robo1

DIOPT Version :9

Sequence 1:	NP_006491.2	Gene:	MCAM / 4162	HGNCID:	6934	Length:	646	Species:	Homo sapiens
Sequence 2:	NP_476899.1	Gene:	robo1 / 37603	FlyBaseID:	FBgn0005631	Length:	1395	Species:	Drosophila melanogaster

Alignment Length:	753	Identity:	140/753 - (18%)
Similarity:	240/753 - (31%)	Gaps:	283/753 - (37%)

- Green bases have known domain annotations that are detailed below.

Human     6 LVCAFLLAACCCCPRVAGVPGEAEQPA----PELVEVEVGSTALLKCGLSQSQGNLS-HVDWF-- 63
            |:.|:||........:..|.|:.:.|.    |..:.|:....|.|.|   :.:|... .::||
  Fly    31 LLPAWLLLVLVASNGLPAVRGQYQSPRIIEHPTDLVVKKNEPATLNC---KVEGKPEPTIEWFKD 92

Human    64 ----SVHKEK---------RTLIFRVRQGQGQSEPGEY----EQRL-SLQDRGATLALT------ 104
                |.:::|         ....:|..||:.:.:.|||    :.|: ....|.|:|.:.
  Fly    93 GEPVSTNEKKSHRVQFKDGALFFYRTMQGKKEQDGGEYWCVAKNRVGQAVSRHASLQIAVLRDDF 157

Human   105 QVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPI 169
            :|.|:|.|:                                      :|....:..|....|.|.
  Fly   158 RVEPKDTRV--------------------------------------AKGETALLECGPPKGIPE 184

Human   170 PQVIWYKNGRPLKEEK-------NRVHI-----------------------QSSQTVESSGLYTL 204
            |.:||.|:|.||.:.|       :||.|                       |:......|....|
  Fly   185 PTLIWIKDGVPLDDLKAMSFGASSRVRIVDGGNLLISNVEPIDEGNYKCIAQNLVGTRESSYAKL 249

Human   205 QSILKAQLVKEDKD--------AQFYCELN--------YRLPSGN---------HMKESREVTVP 244
            ...:|...:||.||        |.|:|.:.        ::...||         |.::|.|::
  Fly   250 IVQVKPYFMKEPKDQVMLYGQTATFHCSVGGDPPPKVLWKKEEGNIPVSRARILHDEKSLEIS-- 312

Human   245 VFYPTEKVWLEVE------------------PVGMLKEGDR--------VEIRCLADGNPPPHFS 283
            ...||::.....|                  |....|....        |::.|:|.|||||...
  Fly   313 NITPTDEGTYVCEAHNNVGQISARASLIVHAPPNFTKRPSNKKVGLNGVVQLPCMASGNPPPSVF 377

Human   284 ISKQN------PSTREAEEETTNDNGVLVLEPARKEHSGRYECQG---LDLDTM-----ISLLSE 334
            .:|:.      |::....:....| |.|.:...|:|..|.|.|..   :|..|:     :|.|.|
  Fly   378 WTKEGVSTLMFPNSSHGRQHVAAD-GTLQITDVRQEDEGYYVCSAFSVVDSSTVRVFLQVSSLDE 441

Human   335 -PQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLE--------RGP 390
             |..:       :::.||.....:||..||.|.|..:.....:|..:  |..::        :|.
  Fly   442 RPPPI-------IQIGPANQTLPKGSVATLPCRATGNPSPRIKWFHD--GHAVQAGNRYSIIQGS 497

Human   391 VLQLHDLKREAGGGYRCVAS------------------------------VPSIPGLNRTQLVNV 425
            .|::.||:....|.|.|.||                              .|:.||..:...|:.
  Fly   498 SLRVDDLQLSDSGTYTCTASGERGETSWAATLTVEKPGSTSLHRAADPSTYPAPPGTPKVLNVSR 562

Human   426 AIFGPPWMAFKER--------------------KVWVKENMVLNLSCEASGHPRPTISWNVNGTA 470
            ......|...:|:                    ..|:       ::.:..|..:.|||....||:
  Fly   563 TSISLRWAKSQEKPGAVGPIIGYTVEYFSPDLQTGWI-------VAAQRVGDTQVTISGLTPGTS 620

Human   471 ------SEQDQD---PQRVLSTLNVLVTPELLETGVECTASNDL--------GKNTSILFLELVN 518
                  :|..|.   |..:.:|:      :.:|...:..::|||        ||:..::....:|
  Fly   621 YVFLVRAENTQGISVPSGLSNTI------KTIEADFDAASANDLSAARTLLTGKSVELIDASAIN 679

Human   519 LTT--------LTPDSNTTTGL-------STSTASPHT 541
            .:.        ::.|.....||       |..:|..|:
  Fly   680 ASAVRLEWMLHVSADEKYVEGLRIHYKDASVPSAQYHS 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MCAM	NP_006491.2	Ig	33..117	CDD:325142	24/110 (22%)
		C2-set_2	139..234	CDD:311910	28/149 (19%)
		Ig_3	261..321	CDD:316449	18/73 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..299		5/26 (19%)
		Ig_3	346..410	CDD:316449	17/71 (24%)
		Ig	450..510	CDD:325142	16/76 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..554		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	620..646
robo1	NP_476899.1	Ig	56..151	CDD:299845	21/97 (22%)
		I-set	56..150	CDD:254352	21/96 (22%)
		I-set	157..251	CDD:254352	22/131 (17%)
		Ig2_Robo	159..251	CDD:143201	22/129 (17%)
		I-set	255..341	CDD:254352	15/87 (17%)
		Ig3_Robo	272..341	CDD:143202	11/70 (16%)
		IG_like	351..436	CDD:214653	20/85 (24%)
		Ig	362..444	CDD:299845	23/82 (28%)
		I-set	445..531	CDD:254352	19/94 (20%)
		IGc2	459..521	CDD:197706	17/63 (27%)
		FN3	549..637	CDD:238020	15/94 (16%)
		FN3	673..762	CDD:238020	7/45 (16%)
		fn3	770..855	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910