Protein Alignment MCAM and Fas3

DIOPT Version :9

• Sequence 1: NP_006491.2
• Gene: MCAM / 4162
• HGNCID: 6934
• Length: 646
• Species: Homo sapiens
• Sequence 2: NP_001097174.1
• Gene: Fas3 / 35097
• FlyBaseID: FBgn0000636
• Length: 577
• Species: Drosophila melanogaster
• Alignment Length: 508
• Identity: 98/508 - (19%)
• Similarity: 159/508 - (31%)
• Gaps: 190/508 - (37%)

Human   195 TVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEP- 258
            |...:||...|..:..:.||...:.|..|.|..   .|..:..:.::.|.:......:.|...|
  Fly    74 TYFGAGLTAGQCGVSIERVKASNNGQVKCSLGV---EGEELSGTIDLVVALRPQQPIIELLSRPN 135

Human   259 -VGMLKEGDRVEIRC-LADGNPPPHFSISKQN-PSTREAEE----ETTNDNGVLVLEPARKEHSG 316
             .|...||.....|| :.||.||.:.|....| |:.:....    .:||||
  Fly   136 REGYFNEGTEFRARCSVRDGRPPANISWYIDNMPANKRTTPLEVMSSTNDN-------------- 186

Human   317 RYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREE 381
                  ::|.|.:      ||:      ...:||      |.|:..|.|.:....|.|
  Fly   187 ------VELSTSV------QEI------QWHLSP------EDSNRKLVCRSHHQTDRE------- 220

Human   382 TGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNV----------AIFGPPWMAFK 436
                                           |:|......::||          |::|
  Fly   221 -------------------------------SVPPQEAAYIINVRYAPVHQPDAAVYG------- 247

Human   437 ERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQ--------DPQRVLSTLNVLVTPELL 493
               ::::...::|::..||  |:|.|.|.::|....|.:        :|| .|......||..:.
  Fly   248 ---LYLEHTAIVNITIRAS--PQPKIEWTIDGAIVGQGRTDGRYSAYEPQ-YLGNDEYNVTLAIA 306

Human   494 ETGVECT-------ASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPHTRANSTSTERK 551
            ...:|.|       |||:||            ||..                 ..|.:|:|   |
  Fly   307 GLTLEDTTKIYNLRASNELG------------LTDY-----------------QVRISSSS---K 339

Human   552 LPEPESRGVVIVAVIVCILVLAVLGAVLYFLYKKGKLPCRRSGKQEITLPPSRKSELVVEVKSDK 616
            .|........||.::|.:.||.::..::.|....|:. |  .|.:.|..|.:       |.:.||
  Fly   340 PPSSSLDVAAIVGIVVAVAVLVLVVLLIVFARATGRW-C--FGGKSIKTPTN-------ETQIDK 394

Human   617 ------------------LPEEMGLLQGS-----SGDKRAPGDQGEKYIDLRH 646
                              .|..:.||..|     :|:....|.|....::.||
  Fly   395 QLELGAQQNHGQNVALLETPNGITLLGASKLREVNGNGNGNGQQDRLSVERRH 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MCAM	NP_006491.2	Ig	33..117	CDD:325142
		C2-set_2	139..234	CDD:311910	10/38 (26%)
		Ig_3	261..321	CDD:316449	15/65 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	278..299		5/25 (20%)
		Ig_3	346..410	CDD:316449	8/63 (13%)
		Ig	450..510	CDD:325142	20/74 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..554		4/28 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	620..646		6/30 (20%)
Fas3	NP_001097174.1	C2-set_2	141..221	CDD:285423	27/155 (17%)
		Ig_TrkABC_d4	235..>333	CDD:143173	25/139 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910