DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MCAM and DIP-theta

DIOPT Version :9

Sequence 1:	NP_006491.2	Gene:	MCAM / 4162	HGNCID:	6934	Length:	646	Species:	Homo sapiens
Sequence 2:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster

Alignment Length:	417	Identity:	85/417 - (20%)
Similarity:	146/417 - (35%)	Gaps:	139/417 - (33%)

- Green bases have known domain annotations that are detailed below.

Human   183 EEKNRV--HIQSSQTVESSGLYTLQSILKAQLVK--EDKDAQFYCELNYRLPSGNHMKESREVTV 243
            ||.:.:  |:...|..:.    .|:.|.:..:|.  .:||...:.||            .:.|||
  Fly    93 EEHDHIAHHLAEMQNKDE----LLEDIREDTVVNAIPEKDLPKFGEL------------LQNVTV 141

Human   244 PVF-----------YPTEKV-WLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQN-PSTREAE 295
            ||.           ..|.|: ||.|:...:|...:.|               |:|.: .|...||
  Fly   142 PVSREAVLQCVVDNLQTYKIAWLRVDTQTILTIQNHV---------------ITKNHRMSITHAE 191

Human   296 EETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVS-----DVRVSPAAPER 355
            :..    .:|.:...::...|.|.||         :.::|.:..|.|:.     |:...|.:.:.
  Fly   192 KRA----WILRIRDVKESDKGWYMCQ---------INTDPMKSQVGYLDVVVPPDILDYPTSTDM 243

Human   356 --QEGSSLTLTCEAESSQDLEFQWLREETGQVLE----------RGPVLQLHDLKREAGGGYRCV 408
              :|||::||.|.|..|......| |.|.|:::.          .|..|.:..:.|...|.|.|:
  Fly   244 VIREGSNVTLKCAATGSPTPTITW-RREGGELIPLPNGAEAVAYNGSFLTIAKVNRLNMGAYLCI 307

Human   409 ASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMV-------LNLSCEASGHPRPTISWNV 466
            ||....|.:::.  |.:.:..||       .:|::..:|       :.|.|::..:|:....|..
  Fly   308 ASNGIPPTVSKR--VMLIVHFPP-------MIWIQNQLVGAALTQNITLECQSEAYPKSINYWMK 363

Human   467 NGTASEQDQDPQRVLSTLNVLV-----TPELLETGVE-------------------CTASNDLGK 507
            |.|                ::|     .||..|:|.:                   |.|.|.||.
  Fly   364 NDT----------------IIVPGERFVPETFESGYKITMRLTIYEVDIQDFGAYRCVAKNSLGD 412

Human   508 NTSILFL----ELVNLTTLTPDSNTTT 530
            ....:.|    :...:||:.|..:..|
  Fly   413 TDGAIKLYHIPQTTTMTTMAPTVSINT 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MCAM	NP_006491.2	Ig	33..117	CDD:325142
		C2-set_2	139..234	CDD:311910	11/54 (20%)
		Ig_3	261..321	CDD:316449	10/60 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..299		5/21 (24%)
		Ig_3	346..410	CDD:316449	19/75 (25%)
		Ig	450..510	CDD:325142	16/83 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..554		1/6 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	620..646
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	25/120 (21%)
		IG_like	137..230	CDD:214653	25/120 (21%)
		IG_like	240..324	CDD:214653	22/86 (26%)
		IGc2	247..310	CDD:197706	19/63 (30%)
		Ig	327..419	CDD:299845	20/114 (18%)
		IG_like	343..420	CDD:214653	16/92 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910