DRSC/TRiP Functional Genomics Resources

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Protein Alignment MCAM and robo3

DIOPT Version :9

Sequence 1:NP_006491.2 Gene:MCAM / 4162 HGNCID:6934 Length:646 Species:Homo sapiens
Sequence 2:NP_608592.2 Gene:robo3 / 33314 FlyBaseID:FBgn0041097 Length:1342 Species:Drosophila melanogaster


Alignment Length:509 Identity:123/509 - (24%)
Similarity:186/509 - (36%) Gaps:127/509 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   113 IFL-----CQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQV 172
            :||     .||..|                 |.|..:|:...|...||..: .|.. .|.|.|.:
  Fly     9 VFLLKWTHAQGSHP-----------------PRIVEHPIDTTVPRHEPATL-NCKA-EGSPTPTI 54

Human   173 IWYKNGRPLK--EEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFY-CELNYRLPSGNH 234
            .|||:|.|||  ...:|:      |:.:.||:    .||....:.:.||..| ||....|    .
  Fly    55 QWYKDGVPLKILPGSHRI------TLPAGGLF----FLKVVNSRRETDAGIYWCEAKNEL----G 105

Human   235 MKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLAD-GNPPPHFSISK--QNPSTREAEE 296
            :..||..|:.|....::..||.:.. .:.:||...:.|.|. |.|.|..:..|  |......::.
  Fly   106 VARSRNATLQVAVLRDEFRLEPQNT-RIAQGDTALLECAAPRGIPEPTVTWKKGGQKLDLEGSKR 169

Human   297 ETTNDNGVLVLEPARKEHSGRYEC-----QGLDLDTMISLLSEPQELLVNYVSDVRVSP---AAP 353
            ....|.|.|.::.||:...|:|:|     .|:...::.:|             .|.|.|   ..|
  Fly   170 VRIVDGGNLAIQDARQTDEGQYQCIAKNPVGVRESSLATL-------------KVHVKPYIIRGP 221

Human   354 ERQ---EGSSLTLTCEAESSQDLEFQWLREETG--QVLERGPVLQLHDLKREA-----GGGYRCV 408
            ..|   ||:|:|..|........:..|||..:|  ..|:|..||:...|:.|.     .|.|.|.
  Fly   222 HDQTVLEGASVTFPCRVGGDPMPDVLWLRTASGGNMPLDRVSVLEDRSLRLERVTIADEGEYSCE 286

Human   409 AS--VPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNV--NGT 469
            |.  |.:|     |.:..:.::.||....:.....|:.....:..|.|.|:|:|||.|.:  |.|
  Fly   287 ADNVVGAI-----TAMGTLTVYAPPKFIQRPASKSVELGADTSFECRAIGNPKPTIFWTIKNNST 346

Human   470 ASEQDQDPQRVLSTLN------VLVTPELLETG----VECTASNDLGKNTSILFLEL-------- 516
            .......|.....:||      :|.......|.    :.|.|.|::...||.:.|.|        
  Fly   347 LIFPGAPPLDRFHSLNTEEGHSILTLTRFQRTDKDLVILCNAMNEVASITSRVQLSLDSQEDRPP 411

Human   517 -------VNLTTLTPDSNTTT------GLSTSTAS---------PHTRANSTST 548
                   ||.|  .|..:..|      ||.:.|.|         |.::.|.|::
  Fly   412 PIIISGPVNQT--LPIKSLATLQCKAIGLPSPTISWYRDGIPVQPSSKLNITTS 463

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MCAMNP_006491.2 Ig 33..117 CDD:325142 2/8 (25%)
C2-set_2 139..234 CDD:311910 29/97 (30%)
Ig_3 261..321 CDD:316449 17/67 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 278..299 4/22 (18%)
Ig_3 346..410 CDD:316449 23/76 (30%)
Ig 450..510 CDD:325142 18/71 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 525..554 8/39 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 620..646
robo3NP_608592.2 Ig 22..117 CDD:299845 33/127 (26%)
I-set 23..116 CDD:254352 32/108 (30%)
I-set 122..211 CDD:254352 21/102 (21%)
Ig 125..211 CDD:299845 21/99 (21%)
I-set 215..302 CDD:254352 25/91 (27%)
Ig 232..302 CDD:299845 19/74 (26%)
I-set 306..401 CDD:254352 22/94 (23%)
Ig 320..411 CDD:299845 22/90 (24%)
I-set 412..492 CDD:254352 12/54 (22%)
IGc2 429..489 CDD:197706 8/35 (23%)
FN3 519..612 CDD:238020
FN3 644..735 CDD:238020
fn3 743..832 CDD:278470
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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