DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MCAM and DIP-alpha

DIOPT Version :9

Sequence 1:	NP_006491.2	Gene:	MCAM / 4162	HGNCID:	6934	Length:	646	Species:	Homo sapiens
Sequence 2:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster

Alignment Length:	378	Identity:	81/378 - (21%)
Similarity:	144/378 - (38%)	Gaps:	93/378 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   176 KNGRPLKEEKNRVH-IQSSQTVESSGLYT---LQSILKAQLVKEDKDAQFYCELNYRLPSGNHMK 236
            :||:.|      :| :.....:|:.|.:.   ::||.... |...:||.|.|.:       .|:.
  Fly    19 RNGKML------IHLLLIVSLLEAIGAFQPEFVESISNVS-VAVGRDATFTCHV-------RHLG 69

Human   237 ESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNP--STREAEEETT 299
            ..|                   ||.|| .|...|:.:       |.::...||  :....::.|.
  Fly    70 GYR-------------------VGWLK-ADTKAIQAI-------HENVITHNPRVTVSHLDQNTW 107

Human   300 NDNGVLVLEPARKEHSGRYECQGLDLDTM------ISLLSEPQELLVNYVSDVRVSPAAPERQEG 358
            |    |.::...:|..|.|.|| |:.|.|      :.::..|..:..:..|||.|       .||
  Fly   108 N----LHIKAVSEEDRGGYMCQ-LNTDPMKSQIGFLDVVIPPDFISEDTSSDVIV-------PEG 160

Human   359 SSLTLTCEAESSQDLEFQWLREETGQVL-------------ERGPVLQLHDLKREAGGGYRCVAS 410
            ||:.|||.|....:....|.||:..:::             .||.||:|..:.|...|.|.|:||
  Fly   161 SSVRLTCRARGYPEPIVTWRREDGNEIVLKDNVGTKTLAPSFRGEVLKLSKISRNEMGSYLCIAS 225

Human   411 VPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTAS---- 471
            ....|.:::.  ::::|...|.:....:.|.......:.:.|.....|: :|::.:..|..
  Fly   226 NGVPPSVSKR--ISLSIHFHPVIQVPNQLVGAPLGTDVQIECHVEASPK-SINYWIKDTGEMIVT 287

Human   472 ----EQDQDPQRVLSTLNVLVTPELLETGV---ECTASNDLGK-NTSILFLEL 516
                ...:..|.:..|...::..:..:..|   .|.|.|.||: ::||...|:
  Fly   288 SGKYHVQESSQSMYETKMSMIVRKFQKDDVGSYRCIAKNSLGEVDSSIRLYEI 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MCAM	NP_006491.2	Ig	33..117	CDD:325142
		C2-set_2	139..234	CDD:311910	13/61 (21%)
		Ig_3	261..321	CDD:316449	13/61 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..299		3/22 (14%)
		Ig_3	346..410	CDD:316449	22/76 (29%)
		Ig	450..510	CDD:325142	12/71 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..554
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	620..646
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	25/119 (21%)
		Ig	51..131	CDD:299845	26/119 (22%)
		I-set	144..240	CDD:254352	28/104 (27%)
		IGc2	159..228	CDD:197706	22/68 (32%)
		Ig	244..337	CDD:299845	16/93 (17%)
		I-set	244..337	CDD:254352	16/93 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910