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Protein Alignment MCAM and him-4

DIOPT Version :9

Sequence 1:	NP_006491.2	Gene:	MCAM / 4162	HGNCID:	6934	Length:	646	Species:	Homo sapiens
Sequence 2:	NP_001024582.1	Gene:	him-4 / 181187	WormBaseID:	WBGene00001863	Length:	5198	Species:	Caenorhabditis elegans

Alignment Length:	552	Identity:	123/552 - (22%)
Similarity:	214/552 - (38%)	Gaps:	120/552 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    27 EAEQPAPELVEVEVGSTAL------LKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQG--QGQS 83
            :.::|...|...:..:||:      |||.:..|..  :.|.||             |:|  .|..
Worm  1357 DVQEPPIILPSTQTNNTAVVGDRVELKCYVEASPP--ASVTWF-------------RRGIAIGTD 1406

Human    84 EPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQ-EYRIQLRVYKAPE--EPNIQVNP 145
            ..|      .:.:...||.:...:.:|..|:.|:...|..: |..:|:.|..:|:  :|::....
Worm  1407 TKG------YVVESDGTLVIQSASVEDATIYTCKASNPAGKAEANLQVTVIASPDIKDPDVVTQE 1465

Human   146 LGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPL---------KEEKNRVHIQSSQTVESSGL 201
               .:....|..:...|..|  |:||:.||.|.:||         .::|.::|:..:: :..||:
Worm  1466 ---SIKESHPFSLYCPVFSN--PLPQISWYLNDKPLIDDKTSWKTSDDKRKLHVFKAK-ITDSGV 1524

Human   202 YTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESR-EVTVPVFYPTEKVWLEVEPVGMLKEG 265
            |...:                     |..:|...|..: ||.||:.....|...:|    ..|||
Worm  1525 YKCVA---------------------RNAAGEGSKSFQVEVIVPLNLDESKYKKKV----FAKEG 1564

Human   266 DRVEIRCLADGNPPPHFSI----SKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQG---- 322
            :.|.:.|...|.|.|..:.    :...|..:......:||...|..:....:..|.|.|..
Worm  1565 EEVTLGCPVSGFPVPQINWVVDGTVVEPGKKYKGATLSNDGLTLHFDSVSVKQEGNYHCVAQSKG 1629

Human   323 --LDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTC--EAESSQDLEFQWL----- 378
              ||:|..:|:|:.|   :|....::.|.       .|..::|:|  :.||.....|.|.
Worm  1630 NILDIDVELSVLAVP---IVGEDDNLEVF-------LGKDISLSCDLQTESDDKTTFVWSINGSE 1684

Human   379 --REETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPG-LNRTQLVNV---AIFGPPWMAFKE 437
              |.:..|:...|..|.:.|.|.|..|.|.|  .|.:..| ..||..::|   .:|..|  .|:.
Worm  1685 SDRPDNVQIPSDGHRLYITDAKPENNGKYMC--RVTNSAGKAERTLTLDVLEPPVFVEP--VFEA 1745

Human   438 RKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPELLETG----VE 498
            .:..:..|.:: |.|:.:|:|:||:.|.::|...::.......||.|.:    |.| ||    :.
Worm  1746 NQKLIGNNPII-LQCQVTGNPKPTVIWKIDGNDVDKSWLFDESLSLLRI----EKL-TGKSAQIS 1804

Human   499 CTASNDLGKNTSILFLELVNLTTLTPDSNTTT 530
            |||.|..|..:...|::.:...|...:.:..|
Worm  1805 CTAENKAGTASRDFFIQNIAAPTFKNEGDQET 1836

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.