DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MCAM and mcam

DIOPT Version :9

Sequence 1:	NP_006491.2	Gene:	MCAM / 4162	HGNCID:	6934	Length:	646	Species:	Homo sapiens
Sequence 2:	XP_004916103.2	Gene:	mcam / 100489907	XenbaseID:	XB-GENE-1002617	Length:	629	Species:	Xenopus tropicalis

Alignment Length:	646	Identity:	241/646 - (37%)
Similarity:	365/646 - (56%)	Gaps:	32/646 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    11 LLAACCCCPRVAGVPGEAEQPAPEL-VEVEVGSTALLKC-GLSQSQGNLSHVDWFSVHKEKRTLI 73
            ||:.|....|     |...||...| |:.:|..|..|.| .....:.|...::|.|....::.:.
Frog     6 LLSLCLLSWR-----GALGQPDGVLQVKAKVSETIKLPCSSYKDGESNNKTLEWLSKKTTEKVIY 65

Human    74 FRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEE 138
            .|...|....:| |.::|:|: |...||.:|.|..|||.||:|:.....::|..:||.|:||||.
Frog    66 RRGPNGLTVPDP-ELKERMSV-DEHFTLEITDVRVQDEMIFICRVVDTSTKEDAVQLLVFKAPES 128

Human   139 PNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYT 203
            |.|.:...... ::.|..|..:|...||||:|.:.||||..|||.::|.|.|.|..|..||||||
Frog   129 PEIIMTKTSFR-STDEISEFGSCKSVNGYPLPTITWYKNDLPLKHKQNEVQISSLNTQLSSGLYT 192

Human   204 LQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWL-EVEPVGMLKEGDR 267
            ::|.|...|.|:|..|..|||::|.||||:||.||.:..:.|.||::.|.| .:.|:|.:||||.
Frog   193 VESSLSLPLQKDDDKADIYCEVSYHLPSGDHMMESEKKNITVLYPSKSVRLFRLFPIGPVKEGDD 257

Human   268 VEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLL 332
            ||::|..||..|...:..      |:.||....:...|:||......||.|||.|:|.:.:...:
Frog   258 VELKCEGDGTMPLDINYK------RKGEELNLGEGPSLILEKVTHSSSGTYECTGMDFENLDESM 316

Human   333 SEPQELLVNYVSDVRVSPAAP-ERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHD 396
            ::..||.|:::.....|..:| ....|..|:::|||.||.:.|..|  :..|.::.....|.|.:
Frog   317 TDEIELQVHFLDQPEFSQMSPVVVHPGDHLSVSCEANSSVETETLW--KHKGHIMAHDSFLTLSE 379

Human   397 LKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPT 461
            :.....|.|.|:.::||:|||:.::.:.:.:.|.|.::...:.::|:||.:..::|:|..||:||
Frog   380 ITHAMSGKYICIVTLPSVPGLSVSKELEIIVKGKPELSVSSKSIYVQENNLATVTCKALAHPKPT 444

Human   462 ISWNVNGTASEQDQDPQRVLSTLNVLVTPELLETG-VECTASNDLGKNTSILFLELVNLTTLTPD 525
            |:|:.|||.||..:.|: :.|.|:.:||.|||:.| |.|.|:|.:|.:...:.|   .|:|..|.
Frog   445 ITWSANGTTSEMMEGPE-ITSELSFIVTSELLDIGVVVCKATNKMGSSKEEIKL---YLSTTPPV 505

Human   526 SNTTTGLSTSTASPHTRANS-----TSTERKLPEPESRGVVIVAVIVCILVLAVLGAVLYFLYKK 585
            |.||:....::.:|.....|     :.|::.:....|.||:||.||:|||:||:|||||||||||
Frog   506 SVTTSSDLLTSPAPENNTGSGNTVPSDTKKDVLRGGSHGVLIVVVIICILLLAILGAVLYFLYKK 570

Human   586 GKLPCRRSGKQEITLPPSRKSELVVEVKSDKLPEEMGLLQGSSGDKRAPGDQGEKYIDLRH 646
            |::||.|||||:|| .|..|.::|||:|.|...||..||.|:. :|:.||||||||:|||:
Frog   571 GRIPCGRSGKQDIT-KPGEKEQIVVEMKPDSPAEESVLLPGAQ-EKKPPGDQGEKYMDLRN 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MCAM	NP_006491.2	Ig	33..117	CDD:325142	25/85 (29%)
		C2-set_2	139..234	CDD:311910	42/94 (45%)
		Ig_3	261..321	CDD:316449	20/59 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..299		4/20 (20%)
		Ig_3	346..410	CDD:316449	17/64 (27%)
		Ig	450..510	CDD:325142	27/60 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..554		6/33 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	620..646		15/25 (60%)
mcam	XP_004916103.2	IGv	34..106	CDD:214650	22/73 (30%)
		Ig strand A'	129..133	CDD:409353	2/3 (67%)
		Ig	137..223	CDD:416386	40/86 (47%)
		Ig strand B	142..154	CDD:409353	3/11 (27%)
		Ig strand C	157..166	CDD:409353	4/8 (50%)
		Ig strand C'	167..170	CDD:409353	0/2 (0%)
		Ig strand D	172..179	CDD:409353	2/6 (33%)
		Ig strand E	184..200	CDD:409353	9/15 (60%)
		Ig strand F	208..216	CDD:409353	4/7 (57%)
		IG	252..324	CDD:214652	25/77 (32%)
		IG	336..410	CDD:214652	21/75 (28%)
		Ig_3	413..486	CDD:404760	29/73 (40%)
		Ig strand A	414..417	CDD:409353	1/2 (50%)
		Ig strand B	431..438	CDD:409353	1/6 (17%)
		Ig strand C	444..449	CDD:409353	3/4 (75%)
		Ig strand D	454..457	CDD:409353	2/2 (100%)
		Ig strand E	460..471	CDD:409353	3/11 (27%)
		Ig strand F	478..485	CDD:409353	3/6 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I29144
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4742
Inparanoid	1	1.050	386	1.000	Inparanoid score	I9292
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D193140at32523
OrthoFinder	1	1.000	-	-		FOG0008740
OrthoInspector	1	1.000	-	-		oto150163
Panther	1	1.100	-	-	LDO	PTHR11973
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9331
SonicParanoid	1	1.000	-	-		X6509
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.190