DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 2mit and CYR1

DIOPT Version :9

Sequence 1:	NP_001262529.1	Gene:	2mit / 41616	FlyBaseID:	FBgn0260793	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_012529.3	Gene:	CYR1 / 853452	SGDID:	S000003542	Length:	2026	Species:	Saccharomyces cerevisiae

Alignment Length:	465	Identity:	117/465 - (25%)
Similarity:	206/465 - (44%)	Gaps:	93/465 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PTSSRLAAE---------REEQQLSRQDVGRLSYQSIHRMLRDENEPDSFRGELRYQQKRHKREL 90
            |||..:..|         |:...|....:..||:  :.:.|.....|..|..|   |::|..|..
Yeast   734 PTSKPILIERKLLLLNGYRKSDPLHIMGIEDLSF--VFKFLFHPVTPSHFTPE---QEQRIMRSE 793

  Fly    91 ELNAPANKLNLTHRDLRTFNSTGGQWKGDFQVITAMDLSSN--------------QLESLSLDNF 141
            .::.....::||...:..:..|        ..|.::|:|:|              :|.||.:.|.
Yeast   794 FVHVDLRNMDLTTPPIIFYQHT--------SEIESLDVSNNANIFLPLEFIESSIKLLSLRMVNI 850

  Fly   142 N------------QLRQLDLGNNSLEVIPLSLADTNMSLPFVT-LDLSCNKFSQISTSFFAQRLP 193
            .            :|..|:|..|.:..:|.|:    |.|..:| |:|.||:...:...|.
Yeast   851 RASKFPSNITKAYKLVSLELQRNFIRKVPNSI----MKLSNLTILNLQCNELESLPAGFV----- 906

  Fly   194 QLKNLNLAHNELLNISRESFY----------NLLELQTLVLSHNNISDIDYETFLALPNLQYLDL 248
            :||||     :||::|...|.          |||::.   ||:|.|..:...| ..|..|..::|
Yeast   907 ELKNL-----QLLDLSSNKFMHYPEVINYCTNLLQID---LSYNKIQSLPQST-KYLVKLAKMNL 962

  Fly   249 SHNRLSGSAIRALQGIPDLVSLSIAYNPDVGVAMQEFVASWSLKELDASGTGLCQVPAALAQSVR 313
            |||:|  :.|..|..:.||.:|::.||   .::..:..|| :|:.|..:...:......|.: :|
Yeast   963 SHNKL--NFIGDLSEMTDLRTLNLRYN---RISSIKTNAS-NLQNLFLTDNRISNFEDTLPK-LR 1020

  Fly   314 TLKLSDNWLKAINCGDMDSYPL-LQYLDLSHSRIAQVEDDALGRLELLESLFLDRNLLMRVPSSL 377
            .|::.:|.:.:|:..|.  ||. :..|.|:.::::.:..:.|.:|..||.|.|::|.|.|:|..:
Yeast  1021 ALEIQENPITSISFKDF--YPKNMTSLTLNKAQLSSIPGELLTKLSFLEKLELNQNNLTRLPQEI 1083

  Fly   378 PPSLEHLFLQ--HNQIMELPPQAFVGLVNLQTLDL-SNNRLIFLPPLSLPKLLTLNLESS--GVE 437
            ....:.:||.  .|::..:||: ...|.:|:|||| |||...|:..:...:|.:||:.|:  |..
Yeast  1084 SKLTKLVFLSVARNKLEYIPPE-LSQLKSLRTLDLHSNNIRDFVDGMENLELTSLNISSNAFGNS 1147

  Fly   438 SVSQSIVHTL 447
            |:..|..|.:
Yeast  1148 SLENSFYHNM 1157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
2mit	NP_001262529.1	LRR_RI	124..355	CDD:238064	65/268 (24%)
		leucine-rich repeat	124..143	CDD:275380	7/44 (16%)
		leucine-rich repeat	144..167	CDD:275380	6/22 (27%)
		leucine-rich repeat	172..194	CDD:275380	6/22 (27%)
		LRR_8	193..253	CDD:290566	22/69 (32%)
		leucine-rich repeat	195..218	CDD:275380	10/32 (31%)
		leucine-rich repeat	219..242	CDD:275380	6/22 (27%)
		LRR_8	241..301	CDD:290566	17/59 (29%)
		leucine-rich repeat	243..311	CDD:275380	18/67 (27%)
		leucine-rich repeat	312..335	CDD:275380	6/22 (27%)
		LRR_8	334..415	CDD:290566	27/84 (32%)
		leucine-rich repeat	336..359	CDD:275380	4/22 (18%)
		leucine-rich repeat	360..380	CDD:275380	8/19 (42%)
		LRR_8	379..460	CDD:290566	23/74 (31%)
		LRR_4	379..>415	CDD:289563	14/38 (37%)
		leucine-rich repeat	381..404	CDD:275380	6/24 (25%)
		leucine-rich repeat	405..449	CDD:275380	17/46 (37%)
CYR1	NP_012529.3	Ad_cyc_g-alpha	368..418	CDD:369912
		RA_PHLPP_like	678..776	CDD:340473	9/43 (21%)
		PLN00113	792..>1273	CDD:215061	102/402 (25%)
		leucine-rich repeat	796..817	CDD:275380	3/28 (11%)
		leucine-rich repeat	818..839	CDD:275380	4/20 (20%)
		leucine-rich repeat	840..864	CDD:275380	4/23 (17%)
		leucine-rich repeat	865..887	CDD:275380	8/25 (32%)
		leucine-rich repeat	888..910	CDD:275380	7/26 (27%)
		leucine-rich repeat	911..933	CDD:275380	5/26 (19%)
		leucine-rich repeat	934..956	CDD:275380	8/25 (32%)
		leucine-rich repeat	957..978	CDD:275380	8/22 (36%)
		leucine-rich repeat	979..1018	CDD:275380	9/42 (21%)
		leucine-rich repeat	1019..1041	CDD:275380	7/23 (30%)
		leucine-rich repeat	1042..1065	CDD:275380	4/22 (18%)
		leucine-rich repeat	1066..1088	CDD:275380	8/21 (38%)
		leucine-rich repeat	1089..1111	CDD:275380	6/22 (27%)
		leucine-rich repeat	1167..1187	CDD:275380
		leucine-rich repeat	1191..1211	CDD:275380
		leucine-rich repeat	1236..1258	CDD:275380
		leucine-rich repeat	1259..1287	CDD:275380
		PP2C	1374..1617	CDD:395385
		CYCc	1613..1825	CDD:214485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X334
TreeFam	1	0.960	-	-
	3	2.870