DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 2mit and Tollo

DIOPT Version :9

Sequence 1:	NP_001262529.1	Gene:	2mit / 41616	FlyBaseID:	FBgn0260793	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster

Alignment Length:	660	Identity:	156/660 - (23%)
Similarity:	229/660 - (34%)	Gaps:	250/660 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LTRLVVAAHLVDIPTSSRLAAER---EEQQLSRQDVGRLSYQSIHRMLRDENEPDSFRGELRYQQ 83
            |..|.:..|..|..|.|...|..   |.:||.|.|   ||..:|..:      ||.....|:..|
  Fly   124 LRNLTIRTHNGDWSTMSLEMASNSFVEFRQLERLD---LSLNNIWLI------PDGMVCPLKSLQ 179

  Fly    84 KRHKRELELNAPANKL----------NLTHRDLRTFNSTGGQWKGDFQVITAMDLSSNQLESL-- 136
                   .|||..||:          :|:.|..|...||          :.::|||:|::.||
  Fly   180 -------HLNASYNKIQDISNFYFSASLSSRKARVCGST----------LQSLDLSANKMVSLPT 227

  Fly   137 -SLDNFNQLRQLDLGNNSLEVIPLSLADTNMSLPFVTLDLSCNKFSQISTSFFAQ---------- 190
             .|....:|..|::..||:..:.....:..:||..|  |||.|:.:.:....||:
  Fly   228 AMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVV--DLSANRLTSLPPELFAETKQLQEIYLR 290

  Fly   191 -------------RLPQLKNLNLAHNELLN--ISRESFYNLLELQTLVLSHNNISDIDYETFLAL 240
                         .|.:|..|:||.|||.:  |:..:|..|..|..|.||.|.||.::...|..|
  Fly   291 NNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPL 355

  Fly   241 PNLQ-------YLD-----------------LSHNRLSGSAIRALQGIPDLVSLSIAYNPDVGVA 281
            .:||       |:|                 ||.||:|....|.|||:.:|:.||:.:|....:.
  Fly   356 ASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMD 420

  Fly   282 MQEFVASWSLKELDASGTGLCQVPAALA--------------------------QSVRTLKLSDN 320
            .:..|....|::|..:...|..||.|||                          :|:..|::::|
  Fly   421 QRSLVNCSQLQDLHLNDNKLQAVPEALAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTEN 485

  Fly   321 WLKAINCGDMDSYPLLQYLDLSHSRIAQVEDDALGRLELLESLFLDRNLLMRV------------ 373
            .|..|..|..|....||.|:||.:::..:|..:|.|...|:::.||.|.|..:
  Fly   486 SLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVW 550

  Fly   374 -----------------------------------------------------------PSSLPP 379
                                                                       .||:|.
  Fly   551 LNISGNRLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPN 615

  Fly   380 SLEHLFLQHNQIMELPPQAFVGLVNLQTLDLSNNRLIFLPPLSL-----------PK-------- 425
            |:|.|:|..|||.::.|..|....||..:||..|||..|.|.:|           |:
  Fly   616 SVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAY 680

  Fly   426 --------LLTLNLESSGVESVSQSIVHTLPQLRDL-----------------LLEDNPIKCSDL 465
                    |..:|.||           .|.|||.||                 |:|   .|..|.
  Fly   681 ECDCNLDWLQKVNRES-----------RTQPQLMDLDQIHCRLAYARGSSHVSLIE---AKSDDF 731

  Fly   466 LGIAEWASPC 475
            |  .::||.|
  Fly   732 L--CKYASHC 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
2mit	NP_001262529.1	LRR_RI	124..355	CDD:238064	79/308 (26%)
		leucine-rich repeat	124..143	CDD:275380	7/21 (33%)
		leucine-rich repeat	144..167	CDD:275380	4/22 (18%)
		leucine-rich repeat	172..194	CDD:275380	7/44 (16%)
		LRR_8	193..253	CDD:290566	26/85 (31%)
		leucine-rich repeat	195..218	CDD:275380	10/24 (42%)
		leucine-rich repeat	219..242	CDD:275380	9/22 (41%)
		LRR_8	241..301	CDD:290566	20/83 (24%)
		leucine-rich repeat	243..311	CDD:275380	26/117 (22%)
		leucine-rich repeat	312..335	CDD:275380	6/22 (27%)
		LRR_8	334..415	CDD:290566	30/151 (20%)
		leucine-rich repeat	336..359	CDD:275380	8/22 (36%)
		leucine-rich repeat	360..380	CDD:275380	8/90 (9%)
		LRR_8	379..460	CDD:290566	32/124 (26%)
		LRR_4	379..>415	CDD:289563	14/35 (40%)
		leucine-rich repeat	381..404	CDD:275380	8/22 (36%)
		leucine-rich repeat	405..449	CDD:275380	15/70 (21%)
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	49/184 (27%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380	6/19 (32%)
		LRR_8	152..222	CDD:290566	25/95 (26%)
		leucine-rich repeat	154..177	CDD:275380	9/31 (29%)
		leucine-rich repeat	178..201	CDD:275380	6/29 (21%)
		LRR	210..656	CDD:227223	108/457 (24%)
		leucine-rich repeat	212..235	CDD:275380	7/22 (32%)
		leucine-rich repeat	236..259	CDD:275380	4/22 (18%)
		leucine-rich repeat	260..283	CDD:275380	8/24 (33%)
		LRR_RI	276..558	CDD:238064	68/281 (24%)
		leucine-rich repeat	284..307	CDD:275380	1/22 (5%)
		leucine-rich repeat	308..333	CDD:275380	10/24 (42%)
		leucine-rich repeat	334..357	CDD:275380	9/22 (41%)
		leucine-rich repeat	358..381	CDD:275380	4/22 (18%)
		leucine-rich repeat	382..405	CDD:275380	9/22 (41%)
		leucine-rich repeat	406..429	CDD:275380	5/22 (23%)
		leucine-rich repeat	430..452	CDD:275380	8/21 (38%)
		leucine-rich repeat	453..500	CDD:275380	7/46 (15%)
		leucine-rich repeat	501..521	CDD:275380	7/19 (37%)
		leucine-rich repeat	525..547	CDD:275380	5/21 (24%)
		leucine-rich repeat	548..573	CDD:275380	0/24 (0%)
		leucine-rich repeat	604..640	CDD:275380	12/35 (34%)
		leucine-rich repeat	641..688	CDD:275380	10/46 (22%)
		leucine-rich repeat	689..816	CDD:275380	18/67 (27%)
		LRR_8	815..875	CDD:290566
		leucine-rich repeat	817..864	CDD:275380
		LRR_8	864..921	CDD:290566
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453510
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940