DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 2mit and Tl

DIOPT Version :9

Sequence 1:	NP_001262529.1	Gene:	2mit / 41616	FlyBaseID:	FBgn0260793	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster

Alignment Length:	974	Identity:	184/974 - (18%)
Similarity:	316/974 - (32%)	Gaps:	324/974 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PTSSRLAAEREEQQLSRQDVGRLSYQSIHRMLRDENEPDSFRGELRYQQKRHKRELELNAPANKL 99
            ||:....::.....::||.:.||     |.:.|           .|:..:|     ..:.|||.|
  Fly   127 PTTLIFESDNLGMNITRQHLDRL-----HGLKR-----------FRFTTRR-----LTHIPANLL 170

  Fly   100 ----NLTHRDLRTFNSTGGQWKGDFQVITAMDLSSNQLESLSLDNFNQLRQLDLGNNSLEVIPLS 160
                ||:|.:||.                    :..::.|...|:...|..::.|:|.|..:|..
  Fly   171 TDMRNLSHLELRA--------------------NIEEMPSHLFDDLENLESIEFGSNKLRQMPRG 215

  Fly   161 LADTNMSLPFVTLDLSCNKFSQISTSFFAQRLPQLKNLNLAHNELLNISRESFYNLLELQTLVLS 225
            :..                           ::|:||.|||..|:|.|:::..|.....:..:.:.
  Fly   216 IFG---------------------------KMPKLKQLNLWSNQLHNLTKHDFEGATSVLGIDIH 253

  Fly   226 HNNISDIDYETFLALPNLQYLDLSHNRLSGSAIRAL-QGIPD-------------------LVSL 270
            .|.|..:.::.|..|.|:..::||.|     ..|:| ||:.|                   |.|.
  Fly   254 DNGIEQLPHDVFAHLTNVTDINLSAN-----LFRSLPQGLFDHNKHLNEVRLMNNRVPLATLPSR 313

  Fly   271 SIAYNPDVGVAMQEFVASWSLKELDASGTGLCQVPAAL---AQSVRTLKLSDNWLKAINCGDMDS 332
            ..|..|::           .:..|.|.   |..:|..|   :..:..:.|.||.||.:....::.
  Fly   314 LFANQPEL-----------QILRLRAE---LQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEH 364

  Fly   333 YPLLQYLDLSHSRIAQVEDDALGRLELLESLFLDRNLLMRVPSSLPPSLEH---LFLQHNQIMEL 394
            ...|..||||::|:..:.|........|..|.|:.|||..:...:..:|.:   |.:..|::..:
  Fly   365 QVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNRLRTI 429

  Fly   395 PPQAFVGLVNLQTLDLSNNRLIFLPPL--------------SLPKLLTLNLESSGVESVSQSIVH 445
            ..:|||....|:.|.|.:|.:....||              .:..||||||.::.:..|.....:
  Fly   430 DSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKN 494

  Fly   446 TLPQLRDL------------------------------------------------------LLE 456
            |:.|||:|                                                      .|.
  Fly   495 TMLQLRELDLSYNNISSLGYEDLAFLSQNRLHVNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLN 559

  Fly   457 DNPIKCSDLLGIAEWASPCRSVDAGQSNGASVSGRVDLKTEYL--QFHNFYENFSSRE------- 512
            |||:.|.  ..|..:....|.|...|     .|.:..|:|:.|  ...|..|....|:
  Fly   560 DNPLVCD--CTILWFIQLVRGVHKPQ-----YSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLI 617

  Fly   513 CGI---RKPENDTKPPSCS-----------LTRASATLTTTPRSMSKVEKSQEAQATATSVEVAA 563
            |.:   ..|.....|..|:           :...|..||..|| :..:.|:.:..
  Fly   618 CPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHVPR-LPNLHKNMQLM---------- 671

  Fly   564 ATAATSEKTGIQATSAAQSTAAATTAEREAIATATSSDTTATPTLAAAAAIQSAGNIPAQLTTKT 628
                                  ....|...:....|::   ||...:..::..|||....:....
  Fly   672 ----------------------ELHLENNTLLRLPSAN---TPGYESVTSLHLAGNNLTSIDVDQ 711

  Fly   629 LRPTETTSLAQLQRRQQM-----PGMPAKTTETPAKNLPSLAQTKATTALPILA-TRDAATATTE 687
            | ||..|.|.......||     .|...:|.:..:..|.........||.|:|. |:|......:
  Fly   712 L-PTNLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFERIGD 775

  Fly   688 ------INSDKPTN-ISGATKTVATSAAEIATPPAIEVPQT-ILAG------------------- 725
                  :|::.||. :..:|..:..:...:....|:.:..| :|||
  Fly   776 RNEMMCVNAEMPTRMVELSTNDICPAEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYA 840

  Fly   726 -------KKSDKMPADKAHETLLKYPTRDTS-------GQVATTPHKHATLQLHVKDRH-LIGTP 775
                   ...:.:..||..:..:.|..:|.|       .|:...|.|   .||.|.:|. |:|
  Fly   841 HNLLLWFVTEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQK---FQLCVHERDWLVG-- 900

  Fly   776 LLMHKGDVLLVDAEQLLLPGTATVADADSEVLDPSQQHQSAE------QEKHQSATDKRQADAI 833
                 |.:    .|.::    .:|||:...::..||....:|      :..|:||.::.::..|
  Fly   901 -----GHI----PENIM----RSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRII 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
2mit	NP_001262529.1	LRR_RI	124..355	CDD:238064	51/253 (20%)
		leucine-rich repeat	124..143	CDD:275380	2/18 (11%)
		leucine-rich repeat	144..167	CDD:275380	5/22 (23%)
		leucine-rich repeat	172..194	CDD:275380	0/21 (0%)
		LRR_8	193..253	CDD:290566	18/59 (31%)
		leucine-rich repeat	195..218	CDD:275380	9/22 (41%)
		leucine-rich repeat	219..242	CDD:275380	4/22 (18%)
		LRR_8	241..301	CDD:290566	15/79 (19%)
		leucine-rich repeat	243..311	CDD:275380	17/90 (19%)
		leucine-rich repeat	312..335	CDD:275380	5/22 (23%)
		LRR_8	334..415	CDD:290566	23/83 (28%)
		leucine-rich repeat	336..359	CDD:275380	7/22 (32%)
		leucine-rich repeat	360..380	CDD:275380	6/19 (32%)
		LRR_8	379..460	CDD:290566	27/151 (18%)
		LRR_4	379..>415	CDD:289563	10/38 (26%)
		leucine-rich repeat	381..404	CDD:275380	6/25 (24%)
		leucine-rich repeat	405..449	CDD:275380	14/57 (25%)
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	19/105 (18%)
		leucine-rich repeat	176..198	CDD:275380	6/41 (15%)
		leucine-rich repeat	199..222	CDD:275380	5/49 (10%)
		LRR_RI	216..542	CDD:238064	74/371 (20%)
		LRR_8	221..281	CDD:290566	18/64 (28%)
		leucine-rich repeat	223..270	CDD:275380	13/46 (28%)
		leucine-rich repeat	271..294	CDD:275380	8/27 (30%)
		leucine-rich repeat	295..320	CDD:275380	3/24 (13%)
		leucine-rich repeat	321..343	CDD:275380	5/35 (14%)
		LRR_8	342..402	CDD:290566	16/59 (27%)
		leucine-rich repeat	344..367	CDD:275380	5/22 (23%)
		leucine-rich repeat	368..391	CDD:275380	7/22 (32%)
		LRR_8	390..450	CDD:290566	16/59 (27%)
		leucine-rich repeat	392..415	CDD:275380	7/22 (32%)
		leucine-rich repeat	416..439	CDD:275380	5/22 (23%)
		leucine-rich repeat	440..474	CDD:275380	6/33 (18%)
		leucine-rich repeat	475..498	CDD:275380	8/22 (36%)
		LRR_8	477..534	CDD:290566	10/56 (18%)
		leucine-rich repeat	499..520	CDD:275380	3/20 (15%)
		leucine-rich repeat	523..552	CDD:275380	0/28 (0%)
		LRRCT	561..619	CDD:214507	14/64 (22%)
		LRRNT	631..667	CDD:214470	7/36 (19%)
		leucine-rich repeat	664..693	CDD:275380	5/63 (8%)
		LRR_8	669..726	CDD:290566	12/92 (13%)
		leucine-rich repeat	694..715	CDD:275380	5/21 (24%)
		leucine-rich repeat	716..737	CDD:275380	5/20 (25%)
		LRRCT	751..800	CDD:214507	10/48 (21%)
		TIR	858..996	CDD:214587	24/112 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453581
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930