Protein Alignment 2mit and cDIP

DIOPT Version :10

• Sequence 1: NP_001262529.1
• Gene: 2mit / 41616
• FlyBaseID: FBgn0260793
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_650951.1
• Gene: cDIP / 42512
• FlyBaseID: FBgn0038865
• Length: 554
• Species: Drosophila melanogaster
• Alignment Length: 550
• Identity: 129/550 - (23%)
• Similarity: 212/550 - (38%)
• Gaps: 144/550 - (26%)

  Fly    33 DIPTSSRLAAEREEQQLSRQDVGRLSYQSIHRMLRDENEPDSFRGELRYQQKRHKRELEL----- 92
            |:||..|:|.:.     :..:||            ||               .|.|.|..
  Fly    73 DLPTEVRIAEDG-----TTYEVG------------DE---------------EHSRTLIFENCTF 105

  Fly    93 -NAPAN---KLNLTHRDLRTFNSTGGQWKGDFQV----ITAMDLSSNQLESLSLDNFNQLRQLD- 148
             |.|..   .|.::..|:|........|: :|.:    :..:.||.|.:|.|....|.....|:
  Fly   106 TNFPLRLFYTLEVSELDMRGCGIRFIYWE-NFSIGADKLVILLLSDNHIEVLPTKTFRGAGNLEF 169

  Fly   149 --LGNNSLEVIPLSLADTNMSLPFVTLDLSCNKFSQISTSFFAQRLPQLKNLNLAHNELLNISRE 211
              |..|.|..:.....|..:.|.:  |||:.|:...::...|| .|..|:::.||.|:|..|..:
  Fly   170 IFLNRNKLGKLQAGAFDNLLKLQY--LDLTENRLEALAADVFA-GLKSLRHVGLAGNQLTTIESD 231

  Fly   212 SFYNLLELQTLVLSHNNISDIDYETFLAL---PNLQYLDLSHNRLSGSAIRALQGIPDLVSLSIA 273
            .|.:..:|.::.:.:|.:.::....|.:.   ..:||:|||:|             |:||.|.:.
  Fly   232 LFAHNPDLLSVAMQNNRLREVGEYAFRSRGRHHQMQYVDLSNN-------------PELVVLLLN 283

  Fly   274 YNPDVGVAMQEFVASWSLKELDASGTGLCQVPAALAQSVRTLKLSDNWLKAINCGDMDSYP---L 335
            .|     |......:.||..::..|            ||..:.||||.::.:      .:|   .
  Fly   284 IN-----ATNLTARNCSLDRVNLYG------------SVTNVDLSDNRVREL------YFPASEA 325

  Fly   336 LQYLDLSHSRIAQVEDDALGRLELLESL-FLDRNLLMRVPSS-LPPSLEHLFLQHNQIMELPPQA 398
            |::|.|.::.:.|:.  :|.|:..|..| ..|...|.::|.. ..|.||.|.|::...||||.:|
  Fly   326 LEHLVLRNNSLVQLA--SLSRVPRLRHLDVADNPNLGQLPDGWRTPHLEMLVLRNTGQMELPLEA 388

  Fly   399 FVGLVNLQTLDLSNNRLIFLPPLSLPKLLTLNLESSGVESVSQSIVHTLPQLRDLLLEDNPIKCS 463
            ..|:.|||.||:|.|.|..:.|.:.|                     ||.||....:..|...|.
  Fly   389 LQGMQNLQKLDISGNNLTEIDPSAFP---------------------TLTQLTHFYIHGNNWNCF 432

  Fly   464 DLLGIAEWASPCRSVDAGQSNGASV---SGRVDLKTEYLQFHNFYENFSSRECGIRKPENDTKPP 525
            .|..|.:...        ::||.:.   :...|...||  ||..       .|..|.||.:....
  Fly   433 SLRNIMDVLI--------RANGIAYTVDNYDPDFPGEY--FHGI-------ACMYRLPEKEGVDS 480

  Fly   526 SCSLTRASATLTTTP----RSMSKVEKSQE 551
            |.| :..||::.::|    ...|:|:|.::
  Fly   481 SSS-SEISASVESSPITSSSDPSEVDKLRD 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
2mit	NP_001262529.1	LRR	<106..458	CDD:443914	90/366 (25%)
		leucine-rich repeat	124..143	CDD:275380	6/18 (33%)
		leucine-rich repeat	144..167	CDD:275380	5/25 (20%)
		leucine-rich repeat	172..194	CDD:275380	7/21 (33%)
		leucine-rich repeat	195..218	CDD:275380	7/22 (32%)
		leucine-rich repeat	219..242	CDD:275380	3/25 (12%)
		leucine-rich repeat	243..311	CDD:275380	15/67 (22%)
		leucine-rich repeat	312..335	CDD:275380	6/25 (24%)
		leucine-rich repeat	336..359	CDD:275380	6/22 (27%)
		leucine-rich repeat	360..380	CDD:275380	5/21 (24%)
		leucine-rich repeat	381..404	CDD:275380	10/22 (45%)
		leucine-rich repeat	405..449	CDD:275380	11/43 (26%)
cDIP	NP_650951.1	LRR	107..>410	CDD:443914	88/344 (26%)
		leucine-rich repeat	118..142	CDD:275380	4/24 (17%)
		leucine-rich repeat	143..166	CDD:275380	6/22 (27%)
		leucine-rich repeat	167..190	CDD:275380	5/22 (23%)
		leucine-rich repeat	191..214	CDD:275380	8/25 (32%)
		leucine-rich repeat	215..238	CDD:275380	7/22 (32%)
		leucine-rich repeat	239..265	CDD:275380	3/25 (12%)
		leucine-rich repeat	266..325	CDD:275380	22/94 (23%)
		leucine-rich repeat	326..347	CDD:275380	6/22 (27%)
		leucine-rich repeat	348..394	CDD:275380	16/45 (36%)
		leucine-rich repeat	395..418	CDD:275380	11/43 (26%)