DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 2mit and CG18249

DIOPT Version :9

Sequence 1:	NP_001262529.1	Gene:	2mit / 41616	FlyBaseID:	FBgn0260793	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001163549.1	Gene:	CG18249 / 40964	FlyBaseID:	FBgn0037553	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	403	Identity:	105/403 - (26%)
Similarity:	165/403 - (40%)	Gaps:	74/403 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 ITAMDLSSNQLESLSLDNFN---QLRQLDLGNNSLEVIPLSLADTNMSLPFVTLDLSCNKFSQIS 184
            :|::.:....|..|....||   :|..|.|..|.:..:.::.......|..  |.|..|..::|.
  Fly   105 LTSLQMQGTSLGVLRDQIFNAVPRLEILQLSQNFIHTVHVAAFQGLSKLRL--LGLQGNAIAEIL 167

  Fly   185 TSFFAQRLPQLKNLNLAHNELLNISRESFYNLLELQTLVLSHNNISDIDYETFLALPNLQYLDLS 249
            :|.. ..|.:|.:|:|:.|||..:.:..|....:||||:|:.|.:..:..:...:||||:.|||.
  Fly   168 SSTL-DPLMELVHLDLSRNELTTLPQNIFAKNKKLQTLLLNGNPLRILMPDVLGSLPNLRLLDLG 231

  Fly   250 HNRLSGSAIRALQGIPDLVSLSIAYNPDVGVAMQEFVASWSLKELDASGTGLCQVPAALAQSVRT 314
            |..........|..:.:||.        .|.::...|.:....:|.|....|..:......||..
  Fly   232 HAAELEVMTLNLTNVQNLVL--------EGSSLSSLVINGGFIKLQAGNNELNHLQVGNKSSVIE 288

  Fly   315 LKLSDNWLKAINCGDMDSYPL------LQYLDLSHSRIAQVED-----DALGRLELLESLFLDRN 368
            :.|..|.|..     .|:..|      ||.||||.:||..:..     ||.|..|||
  Fly   289 MDLHGNLLNG-----NDTAALLRGMWNLQRLDLSKNRIEALPQHGSGLDASGTQELL-------- 340

  Fly   369 LLMRVPSSLPPSLEHLFLQHNQIMELPPQAFVGLVNLQTLDLSNNRLIFLPPL---SLPKLLTLN 430
                    :.|||:.|.|.:||::.|||::.:....|..||||:|.::.|...   ||..|..|.
  Fly   341 --------ILPSLKFLNLANNQLVRLPPESPILSSRLSYLDLSHNLMLTLDVAILRSLSVLKGLY 397

  Fly   431 LESSGVESVSQSIVH-TLPQLRDLLLEDNPIKCSDLLGIAEWASPCRS------VDAG------- 481
            :|.:.:.:::...:| ..|.|.:|.|.|||           |:|....      .|.|
  Fly   398 VEGNRLNTINYQKLHEEHPDLSELGLHDNP-----------WSSGLYRKMFLYFTDRGVHLQARP 451

  Fly   482 QSNGASVSGRVDL 494
            |:...:.|.|||:
  Fly   452 QNRVLNKSSRVDI 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
2mit	NP_001262529.1	LRR_RI	124..355	CDD:238064	62/244 (25%)
		leucine-rich repeat	124..143	CDD:275380	5/21 (24%)
		leucine-rich repeat	144..167	CDD:275380	4/22 (18%)
		leucine-rich repeat	172..194	CDD:275380	6/21 (29%)
		LRR_8	193..253	CDD:290566	21/59 (36%)
		leucine-rich repeat	195..218	CDD:275380	7/22 (32%)
		leucine-rich repeat	219..242	CDD:275380	7/22 (32%)
		LRR_8	241..301	CDD:290566	14/59 (24%)
		leucine-rich repeat	243..311	CDD:275380	13/67 (19%)
		leucine-rich repeat	312..335	CDD:275380	5/22 (23%)
		LRR_8	334..415	CDD:290566	31/91 (34%)
		leucine-rich repeat	336..359	CDD:275380	11/27 (41%)
		leucine-rich repeat	360..380	CDD:275380	1/19 (5%)
		LRR_8	379..460	CDD:290566	29/84 (35%)
		LRR_4	379..>415	CDD:289563	16/35 (46%)
		leucine-rich repeat	381..404	CDD:275380	8/22 (36%)
		leucine-rich repeat	405..449	CDD:275380	13/47 (28%)
CG18249	NP_001163549.1	leucine-rich repeat	57..80	CDD:275380
		LRR_8	104..163	CDD:290566	13/59 (22%)
		leucine-rich repeat	105..128	CDD:275380	5/22 (23%)
		LRR_RI	107..438	CDD:238064	97/373 (26%)
		leucine-rich repeat	129..152	CDD:275380	4/22 (18%)
		leucine-rich repeat	153..176	CDD:275380	7/25 (28%)
		LRR_8	176..232	CDD:290566	20/55 (36%)
		leucine-rich repeat	177..200	CDD:275380	7/22 (32%)
		leucine-rich repeat	201..224	CDD:275380	7/22 (32%)
		leucine-rich repeat	225..258	CDD:275380	9/40 (23%)
		leucine-rich repeat	259..310	CDD:275380	11/55 (20%)
		leucine-rich repeat	311..344	CDD:275380	14/48 (29%)
		LRR_8	343..403	CDD:290566	22/59 (37%)
		leucine-rich repeat	345..368	CDD:275380	8/22 (36%)
		leucine-rich repeat	369..390	CDD:275380	7/20 (35%)
		leucine-rich repeat	393..417	CDD:275380	4/23 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453603
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930