DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 2mit and CG7800

DIOPT Version :9

Sequence 1:	NP_001262529.1	Gene:	2mit / 41616	FlyBaseID:	FBgn0260793	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_649770.1	Gene:	CG7800 / 40963	FlyBaseID:	FBgn0037552	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	423	Identity:	100/423 - (23%)
Similarity:	170/423 - (40%)	Gaps:	67/423 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 TAMDLSSNQLESLSLDNFNQ--------LRQLDLGNNSLEVIPLSLADTNMSLPFVT-LDLSCNK 179
            |..|..:.:|....:|:..:        ||.|:|.|  .:....::.|.| .||::| |.|....
  Fly    37 TFSDKKATKLTEFHMDSCEKKVLKLMPNLRTLELEN--CDSPDFTMNDLN-QLPYLTSLQLRRGN 98

  Fly   180 FSQISTSFFAQRLPQLKNLNLAHNELLNISRESFYNLLELQTLVLSHNNISDIDYETFLALPNLQ 244
            ...:....|: :.|.:|.|.|..|.:..:|.|.|..|.:|..|.|..|.|..:.::.|..||.|.
  Fly    99 LLGLHDEHFS-KWPNMKILMLGGNNITRLSNECFKGLAQLWLLSLPGNGIQGLPWDVFQNLPELL 162

  Fly   245 YLDLSHNRLSGSAIRALQGIPDLVSLSIAYNPDVGVAMQEFVASWSLKELDASGTGL---CQVPA 306
            :||||.||:.........|:|.|..|.:..||...:|.....:..:|:.||.|..|.   ..:|.
  Fly   163 HLDLSGNRIETLHENIFTGVPKLEMLLLNGNPLTWIAPTSLKSLSNLRLLDMSNCGPLPDLSLPG 227

  Fly   307 A--------------LAQSVRTLKLSDNWLKAINCGDMDSYPLLQYLDLSHSRIAQVED-----D 352
            |              :..||..|:...|.:..|...|..|   :..||| ||.:....|     .
  Fly   228 AHTLILDNSGVQRLDILGSVHKLQARKNHITEIKLPDKSS---VIELDL-HSNLLTATDIPKLLT 288

  Fly   353 ALGRLELLESLFLDRNLLMRVPSS---------LPPSLEHLFLQHNQIMELPPQAFVGLVNLQTL 408
            .:.||:.|:   |..|::....::         :.|:|.::.|..|::..|...:.:....|..|
  Fly   289 GMWRLQRLD---LSENIIGIYAAAGSDNTSELFILPNLMYMNLSANRLTRLHFDSPIPWERLTHL 350

  Fly   409 DLSNNRLIFLPPLSLPK---LLTLNLESSGVESVSQSIVHTLPQLRDLLLEDNPIKCSDLLGIAE 470
            |.|.||:.....:.:.:   |.:|:||.:.:.:...:.....|.|:::.|.||..:......|.:
  Fly   351 DASYNRIYAPAKVGIDEAFNLQSLHLEGNYINNFELTPWKPHPSLKEVALYDNKFQPKGYKNITK 415

  Fly   471 WASPCRSVDAGQSNGASVSGRVDLKTEYLQFHN 503
            :.:             .:...|..||:|.|.:|
  Fly   416 FFN-------------EIGVNVLEKTQYSQSNN 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
2mit	NP_001262529.1	LRR_RI	124..355	CDD:238064	68/261 (26%)
		leucine-rich repeat	124..143	CDD:275380	4/18 (22%)
		leucine-rich repeat	144..167	CDD:275380	7/22 (32%)
		leucine-rich repeat	172..194	CDD:275380	4/22 (18%)
		LRR_8	193..253	CDD:290566	23/59 (39%)
		leucine-rich repeat	195..218	CDD:275380	8/22 (36%)
		leucine-rich repeat	219..242	CDD:275380	7/22 (32%)
		LRR_8	241..301	CDD:290566	19/59 (32%)
		leucine-rich repeat	243..311	CDD:275380	21/84 (25%)
		leucine-rich repeat	312..335	CDD:275380	6/22 (27%)
		LRR_8	334..415	CDD:290566	21/94 (22%)
		leucine-rich repeat	336..359	CDD:275380	8/27 (30%)
		leucine-rich repeat	360..380	CDD:275380	3/28 (11%)
		LRR_8	379..460	CDD:290566	20/83 (24%)
		LRR_4	379..>415	CDD:289563	10/35 (29%)
		leucine-rich repeat	381..404	CDD:275380	4/22 (18%)
		leucine-rich repeat	405..449	CDD:275380	10/46 (22%)
CG7800	NP_649770.1	leucine-rich repeat	46..64	CDD:275380	2/17 (12%)
		leucine-rich repeat	65..85	CDD:275380	7/22 (32%)
		LRR_8	87..147	CDD:290566	18/60 (30%)
		leucine-rich repeat	89..112	CDD:275380	4/23 (17%)
		leucine-rich repeat	113..136	CDD:275380	8/22 (36%)
		LRR_RI	<131..334	CDD:238064	53/209 (25%)
		leucine-rich repeat	137..160	CDD:275380	7/22 (32%)
		LRR_8	140..195	CDD:290566	19/54 (35%)
		leucine-rich repeat	161..184	CDD:275380	8/22 (36%)
		leucine-rich repeat	185..208	CDD:275380	5/22 (23%)
		leucine-rich repeat	209..246	CDD:275380	7/36 (19%)
		leucine-rich repeat	247..267	CDD:275380	5/19 (26%)
		leucine-rich repeat	268..292	CDD:275380	6/24 (25%)
		leucine-rich repeat	293..322	CDD:275380	4/31 (13%)
		leucine-rich repeat	395..406	CDD:275378	4/10 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453602
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030